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Open AccessReview

How Fungal Glycans Modulate Platelet Activation via Toll-Like Receptors Contributing to the Escape of Candida albicans from the Immune Response

by 1,2
1
Institut National de la Santé et de la Recherche Médicale U1285, Faculté de Médecine, 1 Place Verdun, 59000 Lille, France
2
UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, Centre National de la Recherche Scientifique, University of Lille, 59000 Lille, France
Antibiotics 2020, 9(7), 385; https://doi.org/10.3390/antibiotics9070385
Received: 21 May 2020 / Revised: 23 June 2020 / Accepted: 6 July 2020 / Published: 7 July 2020
Platelets are essential for vascular repair and for the maintenance of blood homeostasis. They contribute to the immune defence of the host against many infections caused by bacteria, viruses and fungi. Following infection, platelet function is modified, and these cells form aggregates with microorganisms leading, to a decrease in the level of circulating platelets. During candidaemia, mannans, β-glucans and chitin, exposed on the cell wall of Candida albicans, an opportunistic pathogenic yeast of humans, play an important role in modulation of the host response. These fungal polysaccharides are released into the circulation during infection and their detection allows the early diagnosis of invasive fungal infections. However, their role in the modulation of the immune response and, in particular, that of platelets, is not well understood. The structure and solubility of glycans play an important role in the orientation of the immune response of the host. This short review focuses on the effect of fungal β-glucans and chitin on platelet activation and how these glycans modulate platelet activity via Toll-like receptors, contributing to the escape of C. albicans from the immune response. View Full-Text
Keywords: platelets; Candida albicans; glycans; β-glucans; chitin; Toll-like receptors; thrombus; aggregation platelets; Candida albicans; glycans; β-glucans; chitin; Toll-like receptors; thrombus; aggregation
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MDPI and ACS Style

Jawhara, S. How Fungal Glycans Modulate Platelet Activation via Toll-Like Receptors Contributing to the Escape of Candida albicans from the Immune Response. Antibiotics 2020, 9, 385. https://doi.org/10.3390/antibiotics9070385

AMA Style

Jawhara S. How Fungal Glycans Modulate Platelet Activation via Toll-Like Receptors Contributing to the Escape of Candida albicans from the Immune Response. Antibiotics. 2020; 9(7):385. https://doi.org/10.3390/antibiotics9070385

Chicago/Turabian Style

Jawhara, Samir. 2020. "How Fungal Glycans Modulate Platelet Activation via Toll-Like Receptors Contributing to the Escape of Candida albicans from the Immune Response" Antibiotics 9, no. 7: 385. https://doi.org/10.3390/antibiotics9070385

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