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Antibiotics
Volume 13
Issue 8
10.3390/antibiotics13080736
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Article

Complete Growth Inhibition of Pseudomonas aeruginosa by Organo-Selenium-Incorporated Urinary Catheter Material

by
Phat L. Tran
1,
Caroline L. Presson
2,
Md Nayeem Hasan Kashem
3,
Wei Li
3,
Ted W. Reid
1,* and
Werner T. W. de Riese
2
1
Department of Ophthalmology and Visual Sciences, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
2
Department of Urology, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
3
Department of Chemical Engineering, Texas Tech University, Lubbock, TX 79409, USA
*
Author to whom correspondence should be addressed.
Antibiotics 2024, 13(8), 736; https://doi.org/10.3390/antibiotics13080736
Submission received: 10 June 2024 / Revised: 25 July 2024 / Accepted: 2 August 2024 / Published: 6 August 2024
(This article belongs to the Special Issue Green Antimicrobials in Biomedical Engineering: Recent Advances Proposal)
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Abstract

To further investigate the inhibition of Pseudomonas aeruginosa’s in vitro growth and biofilm formation by an organo-selenium-incorporated polyurethane (PU) catheter material. P. aeruginosa, Staphylococcus aureus, and Candida albicans were incubated in vitro with organo-selenium and control polyurethane catheter materials in the presence of glutathione. Growth was evaluated by a colony-forming-unit (CFU) count and visualized with confocal laser scanning microscopy. Two different PU catheter materials were used. Using tin-catalyzed PU catheter material, complete inhibition of S. aureus was seen at 1% selenium (Se), whereas no inhibition was seen for P. aeruginosa at up to 3.0% Se. Whereas, using a thermoplastic PU catheter material, 1.5% Se and 2% Se organo-selenium caused several logs of growth inhibition of P. aeruginosa, and 2.5% selenium, incorporation showed complete inhibition (8 logs). Samples with lower than 1.5% selenium did not show adequate growth inhibition for P. aeruginosa. Similar in vitro growth inhibition was achieved against a multidrug-resistant C. albicans strain. It was concluded that optimal inhibition of P. aeruginosa in vitro growth and biofilm formation occurs with 2.5% selenium incorporated as organo-selenium in a thermoplastic PU catheter material. These results suggest that reduced incidence of CAUTIs (catheter associated urinary tract infections) with P. aeruginosa and other bacteria and fungi can be achieved by using organo-selenium-incorporated catheters.
Keywords: catheter-associated urinary tract infection; selenium; Pseudomonas aeruginosa; in vitro growth inhibition catheter-associated urinary tract infection; selenium; Pseudomonas aeruginosa; in vitro growth inhibition

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MDPI and ACS Style

Tran, P.L.; Presson, C.L.; Kashem, M.N.H.; Li, W.; Reid, T.W.; de Riese, W.T.W. Complete Growth Inhibition of Pseudomonas aeruginosa by Organo-Selenium-Incorporated Urinary Catheter Material. Antibiotics 2024, 13, 736. https://doi.org/10.3390/antibiotics13080736

AMA Style

Tran PL, Presson CL, Kashem MNH, Li W, Reid TW, de Riese WTW. Complete Growth Inhibition of Pseudomonas aeruginosa by Organo-Selenium-Incorporated Urinary Catheter Material. Antibiotics. 2024; 13(8):736. https://doi.org/10.3390/antibiotics13080736

Chicago/Turabian Style

Tran, Phat L., Caroline L. Presson, Md Nayeem Hasan Kashem, Wei Li, Ted W. Reid, and Werner T. W. de Riese. 2024. "Complete Growth Inhibition of Pseudomonas aeruginosa by Organo-Selenium-Incorporated Urinary Catheter Material" Antibiotics 13, no. 8: 736. https://doi.org/10.3390/antibiotics13080736

APA Style

Tran, P. L., Presson, C. L., Kashem, M. N. H., Li, W., Reid, T. W., & de Riese, W. T. W. (2024). Complete Growth Inhibition of Pseudomonas aeruginosa by Organo-Selenium-Incorporated Urinary Catheter Material. Antibiotics, 13(8), 736. https://doi.org/10.3390/antibiotics13080736

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