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Biosensors 2016, 6(3), 47;

Potential of Surface Enhanced Raman Spectroscopy (SERS) in Therapeutic Drug Monitoring (TDM). A Critical Review

Department of Engineering and Architecture, University of Trieste, Via Valerio 6a, 34127 Trieste, Italy
Author to whom correspondence should be addressed.
Academic Editor: Torsten Frosch
Received: 4 July 2016 / Revised: 7 September 2016 / Accepted: 9 September 2016 / Published: 19 September 2016
(This article belongs to the Special Issue Raman and IR Spectroscopic Sensing)
Full-Text   |   PDF [2391 KB, uploaded 19 September 2016]   |  


Surface-Enhanced Raman Spectroscopy (SERS) is a label-free technique that enables quick monitoring of substances at low concentrations in biological matrices. These advantages make it an attractive tool for the development of point-of-care tests suitable for Therapeutic Drug Monitoring (TDM) of drugs with a narrow therapeutic window, such as chemotherapeutic drugs, immunosuppressants, and various anticonvulsants. In this article, the current applications of SERS in the field of TDM for cancer therapy are discussed in detail and illustrated according to the different strategies and substrates. In particular, future perspectives are provided and special concerns regarding the standardization of self-assembly methods and nanofabrication procedures, quality assurance, and technology readiness are critically evaluated. View Full-Text
Keywords: SERS; TDM; drug monitoring; Individualized cancer chemotherapy SERS; TDM; drug monitoring; Individualized cancer chemotherapy

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Jaworska, A.; Fornasaro, S.; Sergo, V.; Bonifacio, A. Potential of Surface Enhanced Raman Spectroscopy (SERS) in Therapeutic Drug Monitoring (TDM). A Critical Review. Biosensors 2016, 6, 47.

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