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Open AccessArticle

Lactate Sensors on Flexible Substrates

1
Electrical Engineering, University of Texas‒Arlington, Arlington, TX 76019, USA
2
Texas A&M Health Science Center, Bryan, TX 77807, USA
*
Author to whom correspondence should be addressed.
The work was conducted when Timothy Fu served as a research assistant at the University of Texas‒Arlington in 2015.
Academic Editor: Donald Y. C. Lie
Biosensors 2016, 6(3), 48; https://doi.org/10.3390/bios6030048
Received: 26 July 2016 / Revised: 1 September 2016 / Accepted: 18 September 2016 / Published: 21 September 2016
(This article belongs to the Special Issue Latest Wearable Biosensors)
Lactate detection by an in situ sensor is of great need in clinical medicine, food processing, and athletic performance monitoring. In this paper, a flexible, easy to fabricate, and low-cost biosensor base on lactate oxidase is presented. The fabrication processes, including metal deposition, sol-gel IrOx deposition, and drop-dry enzyme loading method, are described in detail. The loaded enzyme was examined by scanning electron microscopy. Cyclic voltammetry was used to characterize the sensors. Durability, sensibility, and selectivity of the biosensors were examined. The comparison for different electrode sizes and different sensing film materials was conducted. The sensor could last for four weeks with an average surface area normalized sensitivity of 950 nA/(cm2 mM) and 9250 nA/(cm2 mM) for Au-based electrodes, and IrOx-modified electrodes respectively, both with an electrode size of 100 × 50 μm. The self-referencing method to record noises simultaneously with the working electrode greatly improved sensor sensitivity and selectivity. The sensor showed little response to interference chemicals, such as glutamate and dopamine. View Full-Text
Keywords: flexible substrate; lactate; IrOx; biosensor flexible substrate; lactate; IrOx; biosensor
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MDPI and ACS Style

Yang, X.; Fu, T.; Kota, P.K.; Tjia, M.; Nguyen, C.M.; Chiao, J.-C. Lactate Sensors on Flexible Substrates. Biosensors 2016, 6, 48. https://doi.org/10.3390/bios6030048

AMA Style

Yang X, Fu T, Kota PK, Tjia M, Nguyen CM, Chiao J-C. Lactate Sensors on Flexible Substrates. Biosensors. 2016; 6(3):48. https://doi.org/10.3390/bios6030048

Chicago/Turabian Style

Yang, Xuesong; Fu, Timothy; Kota, Pavan K.; Tjia, Maggie; Nguyen, Cuong M.; Chiao, Jung-Chih. 2016. "Lactate Sensors on Flexible Substrates" Biosensors 6, no. 3: 48. https://doi.org/10.3390/bios6030048

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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