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Biosensors 2016, 6(3), 48;

Lactate Sensors on Flexible Substrates

Electrical Engineering, University of Texas‒Arlington, Arlington, TX 76019, USA
Texas A&M Health Science Center, Bryan, TX 77807, USA
The work was conducted when Timothy Fu served as a research assistant at the University of Texas‒Arlington in 2015.
Author to whom correspondence should be addressed.
Academic Editor: Donald Y. C. Lie
Received: 26 July 2016 / Revised: 1 September 2016 / Accepted: 18 September 2016 / Published: 21 September 2016
(This article belongs to the Special Issue Latest Wearable Biosensors)
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Lactate detection by an in situ sensor is of great need in clinical medicine, food processing, and athletic performance monitoring. In this paper, a flexible, easy to fabricate, and low-cost biosensor base on lactate oxidase is presented. The fabrication processes, including metal deposition, sol-gel IrOx deposition, and drop-dry enzyme loading method, are described in detail. The loaded enzyme was examined by scanning electron microscopy. Cyclic voltammetry was used to characterize the sensors. Durability, sensibility, and selectivity of the biosensors were examined. The comparison for different electrode sizes and different sensing film materials was conducted. The sensor could last for four weeks with an average surface area normalized sensitivity of 950 nA/(cm2 mM) and 9250 nA/(cm2 mM) for Au-based electrodes, and IrOx-modified electrodes respectively, both with an electrode size of 100 × 50 μm. The self-referencing method to record noises simultaneously with the working electrode greatly improved sensor sensitivity and selectivity. The sensor showed little response to interference chemicals, such as glutamate and dopamine. View Full-Text
Keywords: flexible substrate; lactate; IrOx; biosensor flexible substrate; lactate; IrOx; biosensor

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Yang, X.; Fu, T.; Kota, P.K.; Tjia, M.; Nguyen, C.M.; Chiao, J.-C. Lactate Sensors on Flexible Substrates. Biosensors 2016, 6, 48.

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