A Smart Nanovector for Cancer Targeted Drug Delivery Based on Graphene Quantum Dots
AbstractGraphene quantum dots (GQD), the new generation members of graphene-family, have shown promising applications in anticancer therapy. In this study, we report the synthesis of a fluorescent and biocompatible nanovector, based on GQD, for the targeted delivery of an anticancer drug with benzofuran structure (BFG) and bearing the targeting ligand riboflavin (RF, vitamin B2). The highly water-dispersible nanoparticles, synthesized from multi-walled carbon nanotubes (MWCNT) by prolonged acidic treatment, were linked covalently to the drug by means of a cleavable PEG linker while the targeting ligand RF was conjugated to the GQD by π–π interaction using a pyrene linker. The cytotoxic effect of the synthesized drug delivery system (DDS) [email protected] was tested on three cancer cell lines and this effect was compared with that exerted by the same nanovector lacking the RF ligand (GQD-PEG-BFG) or the anticancer drug ([email protected]). The results of biological tests underlined the low cytotoxicity of the GQD sample and the cytotoxic activity of the DDS against the investigated cancer cell lines with a higher or similar potency to that exerted by the BFG alone, thus opening new possibilities for the use of this drug or other anticancer agents endowed of cytotoxicity and serious side effects. View Full-Text
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Iannazzo, D.; Pistone, A.; Celesti, C.; Triolo, C.; Patané, S.; Giofré, S.V.; Romeo, R.; Ziccarelli, I.; Mancuso, R.; Gabriele, B.; Visalli, G.; Facciolà, A.; Di Pietro, A. A Smart Nanovector for Cancer Targeted Drug Delivery Based on Graphene Quantum Dots. Nanomaterials 2019, 9, 282.
Iannazzo D, Pistone A, Celesti C, Triolo C, Patané S, Giofré SV, Romeo R, Ziccarelli I, Mancuso R, Gabriele B, Visalli G, Facciolà A, Di Pietro A. A Smart Nanovector for Cancer Targeted Drug Delivery Based on Graphene Quantum Dots. Nanomaterials. 2019; 9(2):282.Chicago/Turabian Style
Iannazzo, Daniela; Pistone, Alessandro; Celesti, Consuelo; Triolo, Claudia; Patané, Salvatore; Giofré, Salvatore V.; Romeo, Roberto; Ziccarelli, Ida; Mancuso, Raffaella; Gabriele, Bartolo; Visalli, Giuseppa; Facciolà, Alessio; Di Pietro, Angela. 2019. "A Smart Nanovector for Cancer Targeted Drug Delivery Based on Graphene Quantum Dots." Nanomaterials 9, no. 2: 282.
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