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Open AccessArticle

Biocompatible and Biodegradable Magnesium Oxide Nanoparticles with In Vitro Photostable Near-Infrared Emission: Short-Term Fluorescent Markers

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School of Physics, University of Melbourne, Parkville, VIC 3010, Australia
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School of Science, Engineering and Health, RMIT University, Melbourne, VIC 3000, Australia
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Department of Mechanical Engineering, University of Melbourne, Parkville, VIC 3010, Australia
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Faculty of Science and Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia
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Department of Chemical and Biomolecular Engineering, Particulate Fluids Processing Centre, Melbourne, VIC 3010, Australia
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The Department of Surgery, University of Melbourne, Parkville, VIC 3010, Australia
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The Breast Service, Victorian Comprehensive Cancer Centre, Parkville, VIC 3052, Australia
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Department of Physics, Southern University of Science and Technology (SUSTech), Shenzhen 518055, China
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Department of Physics, University of Hong Kong, Pokfulam Road, Hong Kong, China
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Authors to whom correspondence should be addressed.
Nanomaterials 2019, 9(10), 1360; https://doi.org/10.3390/nano9101360
Received: 16 August 2019 / Revised: 13 September 2019 / Accepted: 17 September 2019 / Published: 23 September 2019
(This article belongs to the Special Issue Advanced Biocompatible Nanomaterials)
Imaging of biological matter by using fluorescent nanoparticles (NPs) is becoming a widespread method for in vitro imaging. However, currently there is no fluorescent NP that satisfies all necessary criteria for short-term in vivo imaging: biocompatibility, biodegradability, photostability, suitable wavelengths of absorbance and fluorescence that differ from tissue auto-fluorescence, and near infrared (NIR) emission. In this paper, we report on the photoluminescent properties of magnesium oxide (MgO) NPs that meet all these criteria. The optical defects, attributed to vanadium and chromium ion substitutional defects, emitting in the NIR, are observed at room temperature in NPs of commercial and in-house ball-milled MgO nanoparticles, respectively. As such, the NPs have been successfully integrated into cultured cells and photostable bright in vitro emission from NPs was recorded and analyzed. We expect that numerous biotechnological and medical applications will emerge as this nanomaterial satisfies all criteria for short-term in vivo imaging. View Full-Text
Keywords: magnesium oxide; fluorescence nanoparticles; bioimaging; biomarking; confocal microscopy; cancer cells magnesium oxide; fluorescence nanoparticles; bioimaging; biomarking; confocal microscopy; cancer cells
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MDPI and ACS Style

Khalid, A.; Norello, R.; N. Abraham, A.; Tetienne, J.-P.; J. Karle, T.; W. C. Lui, E.; Xia, K.; A. Tran, P.; J. O’Connor, A.; G. Mann, B.; de Boer, R.; He, Y.; Man Ching Ng, A.; B. Djurisic, A.; Shukla, R.; Tomljenovic-Hanic, S. Biocompatible and Biodegradable Magnesium Oxide Nanoparticles with In Vitro Photostable Near-Infrared Emission: Short-Term Fluorescent Markers. Nanomaterials 2019, 9, 1360.

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