Table of Contents
J. Funct. Biomater., Volume 9, Issue 2 (June 2018)
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Cover Story (view full-size image) Persistence of microorganisms in dentinal tubules after root canal chemo–mechanical preparation is [...] Read more. Persistence of microorganisms in dentinal tubules after root canal chemo–mechanical preparation is well documented in the literature. The complex anatomy of the root canal and dentinal buffering ability make delivery of antibacterial drugs difficult. This work explores the use of a novel trilayered nanoparticle (TNP) drug delivery system that encapsulates chlorhexidine digluconate, used to improve the disinfection of the root canal system. The hydrophilic interior of the TNPs successfully entrapped chlorhexidine digluconate. These TNPs had small mean particle diameter, possessed good encapsulation efficiency, and showed sustained inhibition of bacteria over 21 days. View Paper here.