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Journal of Functional Biomaterials, Volume 15, Issue 8

2024 August - 37 articles

Cover Story: This study introduces innovative core–shell bioresorbable scaffolds, in which a stiff 3D-printed poly(lactic acid) lattice core ensures mechanical support while a bioactive gelatin–chitosan hydrogel is nested throughout the core via grafting and crosslinking to support cell proliferation and differentiation. The scaffolds can be tailored for a specific application by designing the lattice geometry and the core–shell ratio, which both significantly affect its mechanical performance and bioresorption. The core–shell structural stability and mechanical properties are maintained during in vitro degradation experiments. Moreover, the scaffolds highly support hMSCs’ growth and osteogenic differentiation, promoting hydroxyapatite formation. View this paper
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Articles (37)

  • Article
  • Open Access
5 Citations
5,408 Views
13 Pages

Understanding bone surface curvatures is crucial for the advancement of bone material design, as these curvatures play a significant role in the mechanical behavior and functionality of bone structures. Previous studies have demonstrated that bone su...

(This article belongs to the Special Issue Scaffolds and Implants for Bone Regeneration)
  • Article
  • Open Access
4 Citations
2,197 Views
13 Pages

Temperature Changes (ΔT) in Correlation with Number of Implant Osteotomy Preparations in Human Cadaver Tibiae, Comparing Osseodensification (OD) Burs in Clockwise (CW) versus Counterclockwise (CCW) Mode

  • Nikolaos Soldatos,
  • Amanda Heydari,
  • LeRoy Horton,
  • Shayda Sarrami and ,
  • Luke Nordlie,
  • Dongseok Choi and
  • Robin Weltman
  • + 2 authors+ 0 author

(1) Background: OD burs are used in two different modes: (i) CW and (ii) CCW. The purpose of the study was to evaluate the ΔT during the preparation of implant osteotomies in a four-way interaction. (2) Methods: Three hundred and sixty osteotom...

(This article belongs to the Special Issue Feature Papers in Dental Biomaterials (2nd Edition))
  • Article
  • Open Access
9 Citations
3,384 Views
18 Pages

Experimental Analysis of Stress Shielding Effects in Screw Spacers Placed in Porcine Spinal Tissue

  • Elliot Alonso Alcántara-Arreola,
  • Karla Nayeli Silva-Garcés,
  • Jocabed Mendoza-Martínez,
  • Miguel Antonio Cardoso-Palomares and
  • Christopher René Torres-SanMiguel

Bone cortical tissues reorganize and remodel in response to tensile forces acting on them, while compressive forces cause atrophy. However, implants support most of the payload. Bones do not regenerate, and stress shielding occurs. The aim is to anal...

(This article belongs to the Section Biomaterials for Tissue Engineering and Regenerative Medicine)
  • Article
  • Open Access
26 Citations
4,484 Views
23 Pages

Chitosan-Stabilized Selenium Nanoparticles Alleviate High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease (NAFLD) by Modulating the Gut Barrier Function and Microbiota

  • Yuhang Luo,
  • Shujiang Peng,
  • Jintao Cheng,
  • Hongli Yang and ,
  • Lin Lin,
  • Guiling Yang,
  • Yuanxiang Jin,
  • Qingchi Wang and
  • Zhengshun Wen
  • + 4 authors+ 0 author

Low molecular weight chitosan selenium nanoparticles (LCS-SeNPs), a biologically active compound derived from selenium polysaccharides, have demonstrated potential in addressing obesity. However, the mechanism through which LCS-SeNPs alleviate high-f...

(This article belongs to the Special Issue Nanostructured Materials/Biomaterials for Healthcare Applications)
  • Article
  • Open Access
6 Citations
4,001 Views
13 Pages

Lymphatic Regeneration after Popliteal Lymph Node Excision and Implantation of Aligned Nanofibrillar Collagen Scaffolds: An Experimental Rabbit Model

  • José Luis Campos,
  • Gemma Pons,
  • Ali M. Al-Sakkaf,
  • Irene Laura Lusetti and ,
  • Laura Pires,
  • Francisco Javier Vela,
  • Elena Ramos,
  • Verónica Crisóstomo,
  • Francisco Miguel Sánchez-Margallo and
  • Jaume Masiá
  • + 6 authors+ 1 author

Lymphedema presents significant challenges to patients’ quality of life, prompting the exploration of innovative treatments, such as collagen scaffolds, aimed at treating and reducing the risk of lymphedema. We aimed to evaluate the preventive...

(This article belongs to the Topic Advanced Functional Materials for Regenerative Medicine)
  • Article
  • Open Access
4 Citations
4,952 Views
17 Pages

Mechanical Assessment of Denture Polymers Processing Technologies

  • Cristina Modiga,
  • Andreea Stoia,
  • Marius Traian Leretter,
  • Ana Codruţa Chiş and ,
  • Andreea-Violeta Ardelean,
  • Edward-Ronald Azar,
  • Gabriel Kapor,
  • Daniela-Maria Pop,
  • Mihai Romînu and
  • Emanuela-Lidia Petrescu
  • + 7 authors+ 2 authors

Background: Removable prostheses have seen a fundamental change recently because of advances in polymer materials, allowing improved durability and performance. Despite these advancements, notable differences still occur amongst various polymer mater...

(This article belongs to the Special Issue Biomechanical Studies and Biomaterials in Dentistry)
  • Review
  • Open Access
49 Citations
10,056 Views
22 Pages

Biomaterial Scaffolds for Periodontal Tissue Engineering

  • Huanhuan Chen,
  • Guangying Song,
  • Tianmin Xu,
  • Chenda Meng and ,
  • Yunfan Zhang,
  • Tianyi Xin,
  • Tingting Yu,
  • Yifan Lin and
  • Bing Han
  • + 4 authors+ 0 author

Advanced periodontitis poses a significant threat to oral health, causing extensive damage and loss of both hard and soft periodontal tissues. While traditional therapies such as scaling and root planing can effectively halt the disease’s progr...

(This article belongs to the Special Issue Scaffold for Tissue Engineering)
  • Article
  • Open Access
3 Citations
2,151 Views
10 Pages

The present study evaluated the cytocompatibility of three endodontic bioceramics in human periodontal-ligament-derived cells (hPDLCs): MTA Repair HP (HP), MTA Flow White (F), and Nishika Canal Sealer BG multi (BG). In addition, we also evaluated the...

(This article belongs to the Special Issue Advanced Materials for Clinical Endodontic Applications (2nd Edition))
  • Article
  • Open Access
5 Citations
2,570 Views
13 Pages

Surgery Combined with Local Implantation of Doxorubicin-Functionalized Hydroxyapatite Halts Tumor Growth and Prevents Bone Destruction in an Aggressive Osteosarcoma

  • Yang Liu,
  • Tova Corbascio,
  • Jintian Huang,
  • Jacob Engellau and ,
  • Lars Lidgren,
  • Magnus Tägil and
  • Deepak Bushan Raina
  • + 2 authors+ 0 author

Osteosarcoma treatment comprises pre-surgical chemotherapy followed by radical surgery and further chemotherapy cycles, but the prognosis has been far from satisfactory. No new drugs or treatment modalities have been developed for clinical use in the...

(This article belongs to the Section Biomaterials for Cancer Therapies)
  • Article
  • Open Access
6 Citations
2,348 Views
11 Pages

Regeneration of articular cartilage remains a challenge for patients who have undergone cartilage injury, osteochondritis dissecans and osteoarthritis. Here, we describe a new recombinant silk fibroin with basic fibroblast growth factor (bFGF) bindin...

(This article belongs to the Special Issue Biomaterials and Porous Scaffolds for Tissue Engineering and Regenerative Medicine)
  • Review
  • Open Access
48 Citations
5,053 Views
25 Pages

With the rapid development of tumor immunotherapy, nanoparticle vaccines have attracted much attention as potential therapeutic strategies. A systematic review and analysis must be carried out to investigate the effect of mannose modification on the...

(This article belongs to the Special Issue Nanomaterials for Drug Targeting and Drug Delivery)
  • Article
  • Open Access
12 Citations
4,671 Views
12 Pages

Comparison of Optical Properties and Fracture Loads of Multilayer Monolithic Zirconia Crowns with Different Yttria Levels

  • Chien-Ming Kang,
  • Tzu-Yu Peng,
  • Yan-An Wu,
  • Chi-Fei Hsieh and ,
  • Miao-Ching Chi,
  • Hsuan-Yu Wu and
  • Zih-Chan Lin
  • + 2 authors+ 0 author

Multilayer monolithic zirconia, which incorporates polychromatic layers that mimic natural tooth gradients, offers enhanced aesthetics and functionality while reducing debonding risks and improving fabrication efficiency. However, uncertainties remai...

(This article belongs to the Special Issue Advances in Restorative Dentistry Materials)
  • Review
  • Open Access
76 Citations
11,903 Views
34 Pages

A wide range of applications using functionalized magnetic nanoparticles (MNPs) in biomedical applications, such as in biomedicine as well as in biotechnology, have been extensively expanding over the last years. Their potential is tremendous in deli...

(This article belongs to the Special Issue Nanomaterials for Drug Targeting and Drug Delivery)
  • Review
  • Open Access
31 Citations
5,677 Views
27 Pages

Advancements in Nanoporous Materials for Biomedical Imaging and Diagnostics

  • Nargish Parvin,
  • Vineet Kumar,
  • Tapas Kumar Mandal and
  • Sang Woo Joo

This review explores the latest advancements in nanoporous materials and their applications in biomedical imaging and diagnostics. Nanoporous materials possess unique structural features, including high surface area, tunable pore size, and versatile...

(This article belongs to the Section Biomaterials and Devices for Healthcare Applications)
  • Review
  • Open Access
34 Citations
9,172 Views
25 Pages

Nanomaterials in Immunology: Bridging Innovative Approaches in Immune Modulation, Diagnostics, and Therapy

  • George-Alexandru Croitoru,
  • Diana-Cristina Pîrvulescu,
  • Adelina-Gabriela Niculescu,
  • Dragoș Epistatu and ,
  • Marius Rădulescu,
  • Alexandru Mihai Grumezescu and
  • Carmen-Larisa Nicolae
  • + 2 authors+ 0 author

The intersection of immunology and nanotechnology has provided significant advancements in biomedical research and clinical applications over the years. Immunology aims to understand the immune system’s defense mechanisms against pathogens. Nan...

(This article belongs to the Section Biomaterials for Drug Delivery)
  • Article
  • Open Access
2 Citations
3,197 Views
16 Pages

Comparative Study of Zirconium Nitride Multilayer Coatings: Crystallinity, In Vitro Oxidation Behaviour and Tribological Properties Deposited via Sputtering and Arc Deposition

  • Julius C. Dohm,
  • Susann Schmidt,
  • Ana Laura Puente Reyna,
  • Berna Richter and ,
  • Antonio Santana and
  • Thomas M. Grupp
  • + 1 author+ 0 author

This study aims to evaluate and compare the properties of a biomedical clinically established zirconium nitride (ZrN) multilayer coating prepared using two different techniques: pulsed magnetron sputtering and cathodic arc deposition. The investigati...

(This article belongs to the Special Issue Advances in Biomedical Alloys and Surface Modification)
  • Article
  • Open Access
3 Citations
2,595 Views
13 Pages

Cationic Serine-Based Gemini Surfactant:Monoolein Aggregates as Viable and Efficacious Agents for DNA Complexation and Compaction: A Cytotoxicity and Physicochemical Assessment

  • Isabel S. Oliveira,
  • Sandra G. Silva,
  • Andreia C. Gomes,
  • M. Elisabete C. D. Real Oliveira and ,
  • M. Luísa C. do Vale and
  • Eduardo F. Marques
  • + 1 author+ 0 author

Cationic gemini surfactants have emerged as potential gene delivery agents as they can co-assemble with DNA due to a strong electrostatic association. Commonly, DNA complexation is enhanced by the inclusion of a helper lipid (HL), which also plays a...

(This article belongs to the Section Biomaterials for Drug Delivery)
  • Article
  • Open Access
6 Citations
3,722 Views
15 Pages

Fibronectin Functionalization: A Way to Enhance Dynamic Cell Culture on Alginate/Hydroxyapatite Scaffolds

  • Bianca Zumbo,
  • Benedetta Guagnini,
  • Barbara Medagli,
  • Davide Porrelli and
  • Gianluca Turco

Bone defects are a global health concern; bone tissue engineering (BTE) is the most promising alternative to reduce patient morbidity and overcome the inherent drawbacks of autograft and allograft bone. Three-dimensional scaffolds are pivotal in this...

(This article belongs to the Special Issue Functional Scaffolds for Bone and Joint Surgery)
  • Review
  • Open Access
18 Citations
10,797 Views
16 Pages

Exploring Platelet-Rich Plasma Therapy for Knee Osteoarthritis: An In-Depth Analysis

  • Florin Nicolae Blaga,
  • Alexandru Stefan Nutiu,
  • Alex Octavian Lupsa,
  • Nicu Adrian Ghiurau and ,
  • Silviu Valentin Vlad and
  • Timea Claudia Ghitea
  • + 1 author+ 0 author

The use of platelet-rich plasma (PRP) in all medical fields is currently gaining popularity (1). PRP is a biological product that can be defined as a segment of the plasma fraction of autologous blood with a platelet concentration level above the bas...

(This article belongs to the Section Biomaterials for Tissue Engineering and Regenerative Medicine)
  • Review
  • Open Access
18 Citations
4,684 Views
20 Pages

Diabetes mellitus, characterized by enduring hyperglycemia, precipitates oxidative stress, engendering a spectrum of complications, notably increased bone vulnerability. The genesis of reactive oxygen species (ROS), a byproduct of oxygen metabolism,...

(This article belongs to the Section Biomaterials for Tissue Engineering and Regenerative Medicine)
  • Systematic Review
  • Open Access
27 Citations
7,509 Views
40 Pages

Cuttlefish-Bone-Derived Biomaterials in Regenerative Medicine, Dentistry, and Tissue Engineering: A Systematic Review

  • Rihab Adel Al-Rawe,
  • Hasan M. AL-Rammahi,
  • Arief Cahyanto,
  • Azman Ma’amor and ,
  • Yih Miin Liew,
  • Prema Sukumaran and
  • Wan Nurazreena Wan Hassan
  • + 2 authors+ 0 author

Background: Marine ecosystems, covering 70% of Earth’s surface, hold immense biodiversity and potential for biomaterials. Cuttlefish bone (CB) and marine resources have gained attention as eco-friendly biomaterials. Objectives: We aim to compre...

(This article belongs to the Section Biomaterials and Devices for Healthcare Applications)
  • Editorial
  • Open Access
2 Citations
2,369 Views
3 Pages

Innovative Biomaterials: The Cornerstone of Next-Generation Medical Solutions

  • Cristian Scheau,
  • Andreea Cristiana Didilescu and
  • Constantin Caruntu

Over the past decade, 3D printing has gained traction in the medical field, and research has started to concentrate on discovering and developing new printing techniques and novel materials usable in this complex field [...]

(This article belongs to the Special Issue Biomaterials in Medical Diagnosis and Treatment)
  • Article
  • Open Access
3 Citations
4,979 Views
20 Pages

In Vitro Biocompatibility Assessment of Bioengineered PLA-Hydrogel Core–Shell Scaffolds with Mesenchymal Stromal Cells for Bone Regeneration

  • Federica Re,
  • Luciana Sartore,
  • Chiara Pasini,
  • Matteo Ferroni and ,
  • Elisa Borsani,
  • Stefano Pandini,
  • Andrea Bianchetti,
  • Camillo Almici,
  • Lorena Giugno and
  • Domenico Russo
  • + 10 authors+ 5 authors

Human mesenchymal stromal cells (hMSCs), whether used alone or together with three-dimensional scaffolds, are the best-studied postnatal stem cells in regenerative medicine. In this study, innovative composite scaffolds consisting of a core–she...

(This article belongs to the Special Issue Feature Papers in Bone Biomaterials)
  • Review
  • Open Access
36 Citations
7,969 Views
21 Pages

Applications of Bioactive Strontium Compounds in Dentistry

  • Mohamed Mahmoud Abdalla,
  • Osama Sayed,
  • Christie Ying Kei Lung,
  • Vidhyashree Rajasekar and
  • Cynthia Kar Yung Yiu

Divalent cations have captured the interest of researchers in biomedical and dental fields due to their beneficial effects on bone formation. These metallic elements are similar to trace elements found in human bone. Strontium is a divalent cation co...

(This article belongs to the Special Issue Active Biomedical Materials and Their Applications)
  • Article
  • Open Access
2 Citations
2,939 Views
13 Pages

Fine dust causes various disorders, including cardiovascular, neurological, renal, reproductive, motor, systemic, respiratory, and cancerous diseases. Therefore, it is essential to study functional materials to prevent these issues. This study invest...

(This article belongs to the Section Biomaterials and Devices for Healthcare Applications)
  • Review
  • Open Access
5 Citations
5,738 Views
14 Pages

Driven by the rapid advancement and practical implementation of biomaterials, fabrication technologies, and artificial intelligence, artificial neuron devices and systems have emerged as a promising technology for interpreting and transmitting neurol...

(This article belongs to the Section Synthesis of Biomaterials via Advanced Technologies)
  • Article
  • Open Access
7 Citations
4,127 Views
17 Pages

Enhancing the Antimicrobial Properties of Experimental Resin-Based Dental Composites through the Addition of Quaternary Ammonium Salts

  • Joanna Nowak,
  • Maja Zalega,
  • Witold Jakubowski,
  • Monika Domarecka and ,
  • Jerzy Sokołowski and
  • Kinga Bociong
  • + 1 author+ 0 author

Secondary caries is one of the main reasons for dental filling replacement. There is a need to obtain dental restorative material that is able to act against caries-inducing microorganisms. This study explores the antimicrobial properties of cetyltri...

(This article belongs to the Section Dental Biomaterials)
  • Article
  • Open Access
6 Citations
4,594 Views
14 Pages

Cuttlefish Bone-Derived Calcium Phosphate Bioceramics Have Enhanced Osteogenic Properties

  • Boqi Pang,
  • Jiaru Xian,
  • Jiajun Chen,
  • Liqi Ng and ,
  • Mengting Li,
  • Guangchun Zhao,
  • Yixun E,
  • Xiaorui Wang,
  • Xiaxin Cao and
  • Chaozong Liu
  • + 7 authors+ 2 authors

Cuttlefish bones are byproducts of cuttlefish processing and are readily available in the marine food industry. In this study, calcium phosphate bioceramics were prepared from cuttlefish bones using a two-stage hydrothermal calcination process. The r...

(This article belongs to the Section Bone Biomaterials)
  • Communication
  • Open Access
37 Citations
3,787 Views
12 Pages

Polydopamine, a mussel-inspired self-adherent polymer of dopamine, has impressive adhesive properties and thus is one of the most versatile approaches to functionalize tissue engineering scaffolds. To date, many types of polydopamine-functionalized s...

(This article belongs to the Section Biomaterials for Tissue Engineering and Regenerative Medicine)
  • Article
  • Open Access
12 Citations
4,148 Views
17 Pages

The Evaluation of the Trueness of Dental Mastercasts Obtained through Different 3D Printing Technologies

  • Lucian Toma Ciocan,
  • Vlad Gabriel Vasilescu,
  • Mihaela Pantea,
  • Silviu Mirel Pițuru and ,
  • Marina Imre,
  • Alexandra Ripszky Totan and
  • Florin Octavian Froimovici
  • + 2 authors+ 0 author

In contemporary dentistry, several 3D printing techniques, including a stereolithography apparatus (SLA), digital light processing (DLP), liquid crystal display (LCD), and PolyJet 3D inkjet printing technology (PolyJet), are employed for model produc...

(This article belongs to the Special Issue State of the Art in Dental Materials)
  • Article
  • Open Access
4 Citations
3,680 Views
22 Pages

Luteinizing Hormone-Releasing Hormone (LHRH)-Conjugated Cancer Drug Delivery from Magnetite Nanoparticle-Modified Microporous Poly-Di-Methyl-Siloxane (PDMS) Systems for the Targeted Treatment of Triple Negative Breast Cancer Cells

  • Stanley C. Eluu,
  • John D. Obayemi,
  • Danyuo Yiporo,
  • Ali A. Salifu and ,
  • Augustine O. Oko,
  • Killian Onwudiwe,
  • Toyin Aina,
  • Josephine C. Oparah,
  • Chukwudi C. Ezeala and
  • Winston O. Soboyejo
  • + 9 authors+ 4 authors

This study presents LHRH conjugated drug delivery via a magnetite nanoparticle-modified microporous Poly-Di-Methyl-Siloxane (PDMS) system for the targeted suppression of triple-negative breast cancer cells. First, the MNP-modified PDMS devices are fa...

(This article belongs to the Special Issue Functional Nanoparticles/Nanocomposites for Biomedical Applications)
  • Article
  • Open Access
30 Citations
5,905 Views
15 Pages

Enhancing Esthetics in Direct Dental Resin Composite: Investigating Surface Roughness and Color Stability

  • Adrian Ioan Hajdu,
  • Ramona Dumitrescu,
  • Octavia Balean,
  • Dacian Virgil Lalescu and ,
  • Berivan Laura Rebeca Buzatu,
  • Vanessa Bolchis,
  • Lucian Floare,
  • Diana Utu,
  • Daniela Jumanca and
  • Atena Galuscan
  • + 5 authors+ 0 author

Dental restorations must replicate the natural appearance of teeth while ensuring biocompatibility and durability. This study evaluated the surface characteristics and color stability of three dental composites—Herculite Ultra XRV, G-ænia...

(This article belongs to the Special Issue Dental Composite Resin: Characteristics and Future Perspectives)
  • Review
  • Open Access
30 Citations
6,340 Views
24 Pages

Photothermal therapy (PTT) can overcome cancer treatment resistance by enhancing the cell membrane permeability, facilitating drug accumulation, and promoting drug release within the tumor tissue. Iron oxide nanoparticles (IONPs) have emerged as effe...

(This article belongs to the Section Biomaterials for Cancer Therapies)
  • Article
  • Open Access
3 Citations
3,822 Views
15 Pages

Vaginal Ovule Loaded with Bismuth Lipophilic Nanoparticles and Cetylpyridinium Chloride Inhibits Human Cervical Carcinoma and Candida albicans Growth

  • Claudio Cabral-Romero,
  • Rene Hernández-Delgadillo,
  • Jesús Alejandro Torres-Betancourt,
  • Claudia María García-Cuellar and ,
  • Yesennia Sánchez-Pérez,
  • Juan Manuel Solis-Soto,
  • Irene Meester,
  • Nayely Pineda-Aguilar,
  • Sergio Eduardo Nakagoshi-Cepeda and
  • María Argelia Akemi Nakagoshi-Cepeda
  • + 6 authors+ 1 author

Bismuth lipophilic nanoparticles (BisBAL NPs) and cetylpyridinium chloride (CPC) are antineoplastic and antimicrobial in vitro. As a next pre-clinical step, a clinically viable dosage form for vaginal application was developed. Compendial pharmacopei...

(This article belongs to the Section Biomaterials for Cancer Therapies)
  • Article
  • Open Access
4 Citations
2,251 Views
17 Pages

Nano-Reactors Based on Ovotransferrin Organic Skeleton through a Ferroptosis-like Strategy Efficiently Enhance Antibacterial Activity

  • Zihan Zhuo,
  • Chunfang Yin,
  • Zhenqing Zhang,
  • Yumeng Han and ,
  • Haoye Teng,
  • Qi Xu and
  • Changming Li
  • + 2 authors+ 0 author

The issue of bacterial resistance is an escalating problem due to the misuse of antibiotics worldwide. This study introduces a new antibacterial mechanism, the ferroptosis-like death (FLD) of bacteria, and an approach to creating green antibacterial...

(This article belongs to the Special Issue State of the Art in Biomaterials for Drug Delivery)
  • Article
  • Open Access
2 Citations
3,361 Views
14 Pages

This study aimed to assess the key physico-mechanical properties and bonding performance of orthodontic adhesives with graphene addition for bonding a fixed retainer. Transbond LR (3M) and Transbond LV (3M) with no graphene were set as the control gr...

(This article belongs to the Section Dental Biomaterials)
  • Article
  • Open Access
3 Citations
2,411 Views
15 Pages

Addressing the growing problem of antifungal resistance in medicine and agriculture requires the development of new drugs and strategies to preserve the efficacy of existing fungicides. One approach is to utilize delivery technologies. Yeast particle...

(This article belongs to the Special Issue Active Biomedical Materials and Their Applications)
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J. Funct. Biomater. - ISSN 2079-4983