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Journal of Functional Biomaterials, Volume 15, Issue 8

2024 August - 37 articles

Cover Story: This study introduces innovative core–shell bioresorbable scaffolds, in which a stiff 3D-printed poly(lactic acid) lattice core ensures mechanical support while a bioactive gelatin–chitosan hydrogel is nested throughout the core via grafting and crosslinking to support cell proliferation and differentiation. The scaffolds can be tailored for a specific application by designing the lattice geometry and the core–shell ratio, which both significantly affect its mechanical performance and bioresorption. The core–shell structural stability and mechanical properties are maintained during in vitro degradation experiments. Moreover, the scaffolds highly support hMSCs’ growth and osteogenic differentiation, promoting hydroxyapatite formation. View this paper
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Articles (37)

  • Article
  • Open Access
2 Citations
3,849 Views
13 Pages

Understanding bone surface curvatures is crucial for the advancement of bone material design, as these curvatures play a significant role in the mechanical behavior and functionality of bone structures. Previous studies have demonstrated that bone su...

  • Article
  • Open Access
2 Citations
1,513 Views
13 Pages

(1) Background: OD burs are used in two different modes: (i) CW and (ii) CCW. The purpose of the study was to evaluate the ΔT during the preparation of implant osteotomies in a four-way interaction. (2) Methods: Three hundred and sixty osteotom...

  • Article
  • Open Access
5 Citations
2,295 Views
18 Pages

Experimental Analysis of Stress Shielding Effects in Screw Spacers Placed in Porcine Spinal Tissue

  • Elliot Alonso Alcántara-Arreola,
  • Karla Nayeli Silva-Garcés,
  • Jocabed Mendoza-Martínez,
  • Miguel Antonio Cardoso-Palomares and
  • Christopher René Torres-SanMiguel

Bone cortical tissues reorganize and remodel in response to tensile forces acting on them, while compressive forces cause atrophy. However, implants support most of the payload. Bones do not regenerate, and stress shielding occurs. The aim is to anal...

  • Article
  • Open Access
13 Citations
3,305 Views
23 Pages

Chitosan-Stabilized Selenium Nanoparticles Alleviate High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease (NAFLD) by Modulating the Gut Barrier Function and Microbiota

  • Yuhang Luo,
  • Shujiang Peng,
  • Jintao Cheng,
  • Hongli Yang,
  • Lin Lin,
  • Guiling Yang,
  • Yuanxiang Jin,
  • Qingchi Wang and
  • Zhengshun Wen

Low molecular weight chitosan selenium nanoparticles (LCS-SeNPs), a biologically active compound derived from selenium polysaccharides, have demonstrated potential in addressing obesity. However, the mechanism through which LCS-SeNPs alleviate high-f...

  • Article
  • Open Access
3 Citations
2,538 Views
13 Pages

Lymphatic Regeneration after Popliteal Lymph Node Excision and Implantation of Aligned Nanofibrillar Collagen Scaffolds: An Experimental Rabbit Model

  • José Luis Campos,
  • Gemma Pons,
  • Ali M. Al-Sakkaf,
  • Irene Laura Lusetti,
  • Laura Pires,
  • Francisco Javier Vela,
  • Elena Ramos,
  • Verónica Crisóstomo,
  • Francisco Miguel Sánchez-Margallo and
  • Jaume Masiá
  • + 1 author

Lymphedema presents significant challenges to patients’ quality of life, prompting the exploration of innovative treatments, such as collagen scaffolds, aimed at treating and reducing the risk of lymphedema. We aimed to evaluate the preventive...

  • Article
  • Open Access
1 Citations
3,569 Views
17 Pages

Mechanical Assessment of Denture Polymers Processing Technologies

  • Cristina Modiga,
  • Andreea Stoia,
  • Marius Traian Leretter,
  • Ana Codruţa Chiş,
  • Andreea-Violeta Ardelean,
  • Edward-Ronald Azar,
  • Gabriel Kapor,
  • Daniela-Maria Pop,
  • Mihai Romînu and
  • Emanuela-Lidia Petrescu
  • + 2 authors

Background: Removable prostheses have seen a fundamental change recently because of advances in polymer materials, allowing improved durability and performance. Despite these advancements, notable differences still occur amongst various polymer mater...

  • Review
  • Open Access
25 Citations
7,716 Views
22 Pages

Biomaterial Scaffolds for Periodontal Tissue Engineering

  • Huanhuan Chen,
  • Guangying Song,
  • Tianmin Xu,
  • Chenda Meng,
  • Yunfan Zhang,
  • Tianyi Xin,
  • Tingting Yu,
  • Yifan Lin and
  • Bing Han

Advanced periodontitis poses a significant threat to oral health, causing extensive damage and loss of both hard and soft periodontal tissues. While traditional therapies such as scaling and root planing can effectively halt the disease’s progr...

  • Article
  • Open Access
1,709 Views
10 Pages

The present study evaluated the cytocompatibility of three endodontic bioceramics in human periodontal-ligament-derived cells (hPDLCs): MTA Repair HP (HP), MTA Flow White (F), and Nishika Canal Sealer BG multi (BG). In addition, we also evaluated the...

  • Article
  • Open Access
2 Citations
1,842 Views
13 Pages

Osteosarcoma treatment comprises pre-surgical chemotherapy followed by radical surgery and further chemotherapy cycles, but the prognosis has been far from satisfactory. No new drugs or treatment modalities have been developed for clinical use in the...

  • Article
  • Open Access
5 Citations
1,852 Views
11 Pages

Regeneration of articular cartilage remains a challenge for patients who have undergone cartilage injury, osteochondritis dissecans and osteoarthritis. Here, we describe a new recombinant silk fibroin with basic fibroblast growth factor (bFGF) bindin...

  • Review
  • Open Access
19 Citations
3,321 Views
25 Pages

With the rapid development of tumor immunotherapy, nanoparticle vaccines have attracted much attention as potential therapeutic strategies. A systematic review and analysis must be carried out to investigate the effect of mannose modification on the...

  • Article
  • Open Access
7 Citations
3,121 Views
12 Pages

Comparison of Optical Properties and Fracture Loads of Multilayer Monolithic Zirconia Crowns with Different Yttria Levels

  • Chien-Ming Kang,
  • Tzu-Yu Peng,
  • Yan-An Wu,
  • Chi-Fei Hsieh,
  • Miao-Ching Chi,
  • Hsuan-Yu Wu and
  • Zih-Chan Lin

Multilayer monolithic zirconia, which incorporates polychromatic layers that mimic natural tooth gradients, offers enhanced aesthetics and functionality while reducing debonding risks and improving fabrication efficiency. However, uncertainties remai...

  • Review
  • Open Access
45 Citations
8,973 Views
34 Pages

A wide range of applications using functionalized magnetic nanoparticles (MNPs) in biomedical applications, such as in biomedicine as well as in biotechnology, have been extensively expanding over the last years. Their potential is tremendous in deli...

  • Review
  • Open Access
20 Citations
3,898 Views
27 Pages

Advancements in Nanoporous Materials for Biomedical Imaging and Diagnostics

  • Nargish Parvin,
  • Vineet Kumar,
  • Tapas Kumar Mandal and
  • Sang Woo Joo

This review explores the latest advancements in nanoporous materials and their applications in biomedical imaging and diagnostics. Nanoporous materials possess unique structural features, including high surface area, tunable pore size, and versatile...

  • Review
  • Open Access
20 Citations
7,052 Views
25 Pages

Nanomaterials in Immunology: Bridging Innovative Approaches in Immune Modulation, Diagnostics, and Therapy

  • George-Alexandru Croitoru,
  • Diana-Cristina Pîrvulescu,
  • Adelina-Gabriela Niculescu,
  • Dragoș Epistatu,
  • Marius Rădulescu,
  • Alexandru Mihai Grumezescu and
  • Carmen-Larisa Nicolae

The intersection of immunology and nanotechnology has provided significant advancements in biomedical research and clinical applications over the years. Immunology aims to understand the immune system’s defense mechanisms against pathogens. Nan...

  • Article
  • Open Access
2 Citations
1,918 Views
16 Pages

This study aims to evaluate and compare the properties of a biomedical clinically established zirconium nitride (ZrN) multilayer coating prepared using two different techniques: pulsed magnetron sputtering and cathodic arc deposition. The investigati...

  • Article
  • Open Access
1 Citations
2,062 Views
13 Pages

Cationic Serine-Based Gemini Surfactant:Monoolein Aggregates as Viable and Efficacious Agents for DNA Complexation and Compaction: A Cytotoxicity and Physicochemical Assessment

  • Isabel S. Oliveira,
  • Sandra G. Silva,
  • Andreia C. Gomes,
  • M. Elisabete C. D. Real Oliveira,
  • M. Luísa C. do Vale and
  • Eduardo F. Marques

Cationic gemini surfactants have emerged as potential gene delivery agents as they can co-assemble with DNA due to a strong electrostatic association. Commonly, DNA complexation is enhanced by the inclusion of a helper lipid (HL), which also plays a...

  • Article
  • Open Access
4 Citations
2,962 Views
15 Pages

Fibronectin Functionalization: A Way to Enhance Dynamic Cell Culture on Alginate/Hydroxyapatite Scaffolds

  • Bianca Zumbo,
  • Benedetta Guagnini,
  • Barbara Medagli,
  • Davide Porrelli and
  • Gianluca Turco

Bone defects are a global health concern; bone tissue engineering (BTE) is the most promising alternative to reduce patient morbidity and overcome the inherent drawbacks of autograft and allograft bone. Three-dimensional scaffolds are pivotal in this...

  • Review
  • Open Access
9 Citations
8,927 Views
16 Pages

Exploring Platelet-Rich Plasma Therapy for Knee Osteoarthritis: An In-Depth Analysis

  • Florin Nicolae Blaga,
  • Alexandru Stefan Nutiu,
  • Alex Octavian Lupsa,
  • Nicu Adrian Ghiurau,
  • Silviu Valentin Vlad and
  • Timea Claudia Ghitea

The use of platelet-rich plasma (PRP) in all medical fields is currently gaining popularity (1). PRP is a biological product that can be defined as a segment of the plasma fraction of autologous blood with a platelet concentration level above the bas...

  • Review
  • Open Access
10 Citations
3,409 Views
20 Pages

Diabetes mellitus, characterized by enduring hyperglycemia, precipitates oxidative stress, engendering a spectrum of complications, notably increased bone vulnerability. The genesis of reactive oxygen species (ROS), a byproduct of oxygen metabolism,...

  • Systematic Review
  • Open Access
15 Citations
5,408 Views
40 Pages

Cuttlefish-Bone-Derived Biomaterials in Regenerative Medicine, Dentistry, and Tissue Engineering: A Systematic Review

  • Rihab Adel Al-Rawe,
  • Hasan M. AL-Rammahi,
  • Arief Cahyanto,
  • Azman Ma’amor,
  • Yih Miin Liew,
  • Prema Sukumaran and
  • Wan Nurazreena Wan Hassan

Background: Marine ecosystems, covering 70% of Earth’s surface, hold immense biodiversity and potential for biomaterials. Cuttlefish bone (CB) and marine resources have gained attention as eco-friendly biomaterials. Objectives: We aim to compre...

  • Editorial
  • Open Access
2 Citations
2,018 Views
3 Pages

Innovative Biomaterials: The Cornerstone of Next-Generation Medical Solutions

  • Cristian Scheau,
  • Andreea Cristiana Didilescu and
  • Constantin Caruntu

Over the past decade, 3D printing has gained traction in the medical field, and research has started to concentrate on discovering and developing new printing techniques and novel materials usable in this complex field [...]

  • Article
  • Open Access
2 Citations
4,312 Views
20 Pages

In Vitro Biocompatibility Assessment of Bioengineered PLA-Hydrogel Core–Shell Scaffolds with Mesenchymal Stromal Cells for Bone Regeneration

  • Federica Re,
  • Luciana Sartore,
  • Chiara Pasini,
  • Matteo Ferroni,
  • Elisa Borsani,
  • Stefano Pandini,
  • Andrea Bianchetti,
  • Camillo Almici,
  • Lorena Giugno and
  • Domenico Russo
  • + 5 authors

Human mesenchymal stromal cells (hMSCs), whether used alone or together with three-dimensional scaffolds, are the best-studied postnatal stem cells in regenerative medicine. In this study, innovative composite scaffolds consisting of a core–she...

  • Review
  • Open Access
22 Citations
5,547 Views
21 Pages

Applications of Bioactive Strontium Compounds in Dentistry

  • Mohamed Mahmoud Abdalla,
  • Osama Sayed,
  • Christie Ying Kei Lung,
  • Vidhyashree Rajasekar and
  • Cynthia Kar Yung Yiu

Divalent cations have captured the interest of researchers in biomedical and dental fields due to their beneficial effects on bone formation. These metallic elements are similar to trace elements found in human bone. Strontium is a divalent cation co...

  • Article
  • Open Access
1 Citations
2,074 Views
13 Pages

Fine dust causes various disorders, including cardiovascular, neurological, renal, reproductive, motor, systemic, respiratory, and cancerous diseases. Therefore, it is essential to study functional materials to prevent these issues. This study invest...

  • Review
  • Open Access
3 Citations
4,170 Views
14 Pages

Driven by the rapid advancement and practical implementation of biomaterials, fabrication technologies, and artificial intelligence, artificial neuron devices and systems have emerged as a promising technology for interpreting and transmitting neurol...

  • Article
  • Open Access
3 Citations
2,923 Views
17 Pages

Enhancing the Antimicrobial Properties of Experimental Resin-Based Dental Composites through the Addition of Quaternary Ammonium Salts

  • Joanna Nowak,
  • Maja Zalega,
  • Witold Jakubowski,
  • Monika Domarecka,
  • Jerzy Sokołowski and
  • Kinga Bociong

Secondary caries is one of the main reasons for dental filling replacement. There is a need to obtain dental restorative material that is able to act against caries-inducing microorganisms. This study explores the antimicrobial properties of cetyltri...

  • Article
  • Open Access
3 Citations
2,804 Views
14 Pages

Cuttlefish Bone-Derived Calcium Phosphate Bioceramics Have Enhanced Osteogenic Properties

  • Boqi Pang,
  • Jiaru Xian,
  • Jiajun Chen,
  • Liqi Ng,
  • Mengting Li,
  • Guangchun Zhao,
  • Yixun E,
  • Xiaorui Wang,
  • Xiaxin Cao and
  • Chaozong Liu
  • + 2 authors

Cuttlefish bones are byproducts of cuttlefish processing and are readily available in the marine food industry. In this study, calcium phosphate bioceramics were prepared from cuttlefish bones using a two-stage hydrothermal calcination process. The r...

  • Communication
  • Open Access
33 Citations
2,985 Views
12 Pages

Polydopamine, a mussel-inspired self-adherent polymer of dopamine, has impressive adhesive properties and thus is one of the most versatile approaches to functionalize tissue engineering scaffolds. To date, many types of polydopamine-functionalized s...

  • Article
  • Open Access
9 Citations
2,784 Views
17 Pages

The Evaluation of the Trueness of Dental Mastercasts Obtained through Different 3D Printing Technologies

  • Lucian Toma Ciocan,
  • Vlad Gabriel Vasilescu,
  • Mihaela Pantea,
  • Silviu Mirel Pițuru,
  • Marina Imre,
  • Alexandra Ripszky Totan and
  • Florin Octavian Froimovici

In contemporary dentistry, several 3D printing techniques, including a stereolithography apparatus (SLA), digital light processing (DLP), liquid crystal display (LCD), and PolyJet 3D inkjet printing technology (PolyJet), are employed for model produc...

  • Article
  • Open Access
3 Citations
3,094 Views
22 Pages

Luteinizing Hormone-Releasing Hormone (LHRH)-Conjugated Cancer Drug Delivery from Magnetite Nanoparticle-Modified Microporous Poly-Di-Methyl-Siloxane (PDMS) Systems for the Targeted Treatment of Triple Negative Breast Cancer Cells

  • Stanley C. Eluu,
  • John D. Obayemi,
  • Danyuo Yiporo,
  • Ali A. Salifu,
  • Augustine O. Oko,
  • Killian Onwudiwe,
  • Toyin Aina,
  • Josephine C. Oparah,
  • Chukwudi C. Ezeala and
  • Winston O. Soboyejo
  • + 4 authors

This study presents LHRH conjugated drug delivery via a magnetite nanoparticle-modified microporous Poly-Di-Methyl-Siloxane (PDMS) system for the targeted suppression of triple-negative breast cancer cells. First, the MNP-modified PDMS devices are fa...

  • Article
  • Open Access
20 Citations
4,231 Views
15 Pages

Enhancing Esthetics in Direct Dental Resin Composite: Investigating Surface Roughness and Color Stability

  • Adrian Ioan Hajdu,
  • Ramona Dumitrescu,
  • Octavia Balean,
  • Dacian Virgil Lalescu,
  • Berivan Laura Rebeca Buzatu,
  • Vanessa Bolchis,
  • Lucian Floare,
  • Diana Utu,
  • Daniela Jumanca and
  • Atena Galuscan

Dental restorations must replicate the natural appearance of teeth while ensuring biocompatibility and durability. This study evaluated the surface characteristics and color stability of three dental composites—Herculite Ultra XRV, G-ænia...

  • Review
  • Open Access
21 Citations
4,574 Views
24 Pages

Photothermal therapy (PTT) can overcome cancer treatment resistance by enhancing the cell membrane permeability, facilitating drug accumulation, and promoting drug release within the tumor tissue. Iron oxide nanoparticles (IONPs) have emerged as effe...

  • Article
  • Open Access
2 Citations
2,768 Views
15 Pages

Vaginal Ovule Loaded with Bismuth Lipophilic Nanoparticles and Cetylpyridinium Chloride Inhibits Human Cervical Carcinoma and Candida albicans Growth

  • Claudio Cabral-Romero,
  • Rene Hernández-Delgadillo,
  • Jesús Alejandro Torres-Betancourt,
  • Claudia María García-Cuellar,
  • Yesennia Sánchez-Pérez,
  • Juan Manuel Solis-Soto,
  • Irene Meester,
  • Nayely Pineda-Aguilar,
  • Sergio Eduardo Nakagoshi-Cepeda and
  • María Argelia Akemi Nakagoshi-Cepeda
  • + 1 author

Bismuth lipophilic nanoparticles (BisBAL NPs) and cetylpyridinium chloride (CPC) are antineoplastic and antimicrobial in vitro. As a next pre-clinical step, a clinically viable dosage form for vaginal application was developed. Compendial pharmacopei...

  • Article
  • Open Access
2 Citations
1,807 Views
17 Pages

The issue of bacterial resistance is an escalating problem due to the misuse of antibiotics worldwide. This study introduces a new antibacterial mechanism, the ferroptosis-like death (FLD) of bacteria, and an approach to creating green antibacterial...

  • Article
  • Open Access
2,205 Views
14 Pages

This study aimed to assess the key physico-mechanical properties and bonding performance of orthodontic adhesives with graphene addition for bonding a fixed retainer. Transbond LR (3M) and Transbond LV (3M) with no graphene were set as the control gr...

  • Article
  • Open Access
2 Citations
2,030 Views
15 Pages

Addressing the growing problem of antifungal resistance in medicine and agriculture requires the development of new drugs and strategies to preserve the efficacy of existing fungicides. One approach is to utilize delivery technologies. Yeast particle...

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J. Funct. Biomater. - ISSN 2079-4983