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Journal of Functional Biomaterials, Volume 12, Issue 1

2021 March - 20 articles

Cover Story: Currently, there is a high demand for suitable implants for osteochondral tissue regeneration. The extremely high incidence of lesions and diseases in the aging population justifies that researchers gather efforts to aim for functional tissue regeneration, considering both hyaline cartilage and subchondral bone and their interface. These research efforts are yielding different biomaterials and manufacturing strategies fostering personalized regeneration. Knowing how to combine suitable biomaterials with fitting manufacturing and the desired stimuli and bioactive compounds still represents a significant challenge. This review examined the state of the art regarding the challenges, advantages, and drawbacks of the current strategies for osteochondral regeneration. View this paper
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Articles (20)

  • Article
  • Open Access
26 Citations
5,652 Views
23 Pages

In addition to biocompatibility, an ideal scaffold for the regeneration of valvular tissue should also replicate the natural heart valve extracellular matrix (ECM) in terms of biomechanical properties and structural stability. In our previous paper,...

  • Article
  • Open Access
12 Citations
3,387 Views
16 Pages

Cryo-Structured Materials Based on Polyvinyl Alcohol and Hydroxyapatite for Osteogenesis

  • Daria N. Lytkina,
  • Dmitriy A. Fedorishin,
  • Polina M. Kalachikova,
  • Anastasiya A. Plyaskina,
  • Aleksandr R. Babeshin and
  • Irina A. Kurzina

The application of various materials in biomedical procedures has recently experienced rapid growth. One of the areas is the treatment of many of different types of bone-related diseases and disorders by using biodegradable polymer-ceramic composites...

  • Article
  • Open Access
16 Citations
3,790 Views
15 Pages

Unique biosynthetic abilities revealed by plants determine in vitro cultures of hairy roots as a suitable source of pharmaceutically relevant bioactive compounds. The basic aim of the study was to examine the applicability of aerogel composed of meth...

  • Review
  • Open Access
30 Citations
7,145 Views
17 Pages

Due to the extremely high incidence of lesions and diseases in aging population, it is critical to put all efforts into developing a successful implant for osteochondral tissue regeneration. Many of the patients undergoing surgery present osteochondr...

  • Article
  • Open Access
33 Citations
5,773 Views
17 Pages

Effects of Process Parameters on Structure and Properties of Melt-Blown Poly(Lactic Acid) Nonwovens for Skin Regeneration

  • Ewa Dzierzkowska,
  • Anna Scisłowska-Czarnecka,
  • Marcin Kudzin,
  • Maciej Boguń,
  • Piotr Szatkowski,
  • Marcin Gajek,
  • Kamil Kornaus,
  • Magdalena Chadzinska and
  • Ewa Stodolak-Zych

Skin regeneration requires a three-dimensional (3D) scaffold for cell adhesion, growth and proliferation. A type of the scaffold offering a 3D structure is a nonwoven material produced via a melt-blown technique. Process parameters of this technique...

  • Article
  • Open Access
6 Citations
3,819 Views
13 Pages

Characterization of Dental Pulp Stem Cell Responses to Functional Biomaterials Including Mineralized Trioxide Aggregates

  • Sejin Bae,
  • Bueonguk Kang,
  • Hyungbin Lee,
  • Harrison Luu,
  • Eric Mullins and
  • Karl Kingsley

Introduction: Many studies in stem cell biology have demonstrated that dental pulp stem cells (DPSC) may be highly proliferative and capable of pluripotent differentiation into many different tissue types. Recent advances in stem cell research have o...

  • Review
  • Open Access
37 Citations
7,425 Views
20 Pages

Bioactive Polymeric Materials for the Advancement of Regenerative Medicine

  • Anthony Iovene,
  • Yuwen Zhao,
  • Shue Wang and
  • Kagya Amoako

Biopolymers are widely accepted natural materials in regenerative medicine, and further development of their bioactivities and discoveries on their composition/function relationships could greatly advance the field. However, a concise insight on comm...

  • Article
  • Open Access
7 Citations
4,533 Views
15 Pages

Preliminary Studies on Graphene-Reinforced 3D Products Obtained by the One-Stage Sacrificial Template Method for Bone Reconstruction Applications

  • Aura-Cătălina Mocanu,
  • Florin Miculescu,
  • George E. Stan,
  • Robert-Cătălin Ciocoiu,
  • Mihai Cosmin Corobea,
  • Marian Miculescu and
  • Lucian Toma Ciocan

The bone remodeling field has shifted focus towards the delineation of products with two main critical attributes: internal architectures capable to promote fast cell colonization and good mechanical performance. In this paper, Luffa-fibers and graph...

  • Article
  • Open Access
19 Citations
3,409 Views
16 Pages

Long-Term Assessment of the In Vitro Corrosion Resistance of Biomimetic ACP Coatings Electrodeposited from an Acetate Bath

  • Patrycja Osak,
  • Joanna Maszybrocka,
  • Julian Kubisztal,
  • Patryk Ratajczak and
  • Bożena Łosiewicz

Calcium phosphate coatings are able to improve the osseointegration process due to their chemical composition, which is similar to that of bone tissues. In this work, to increase the long-term corrosion resistance and to improve the osseointegration...

  • Article
  • Open Access
20 Citations
4,114 Views
14 Pages

Electrospun Poly(butylene-adipate-co-terephthalate)/Nano-hyDroxyapatite/Graphene Nanoribbon Scaffolds Improved the In Vivo Osteogenesis of the Neoformed Bone

  • Luana Marotta Reis Vasconcellos,
  • Gabriela F. Santana-Melo,
  • Edmundo Silva,
  • Vanessa Fernandes Pereira,
  • Juliani Caroline Ribeiro Araújo,
  • André Diniz Rosa Silva,
  • André S. A. Furtado,
  • Conceição de Maria Vaz Elias,
  • Bartolomeu Cruz Viana and
  • Anderson Oliveira Lobo
  • + 1 author

Electrospun ultrathin fibrous scaffold filed with synthetic nanohydroxyapatite (nHAp) and graphene nanoribbons (GNR) has bioactive and osteoconductive properties and is a plausible strategy to improve bone regeneration. Poly(butylene-adipate-co-terep...

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J. Funct. Biomater. - ISSN 2079-4983