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Article

MTMS-Based Aerogel Constructs for Immobilization of Plant Hairy Roots: Effects on Proliferation of Rindera graeca Biomass and Extracellular Secretion of Naphthoquinones

1
Faculty of Chemical and Process Engineering, Warsaw University of Technology, Waryńskiego 1, 00-645 Warsaw, Poland
2
Department of Pharmaceutical Biology and Medicinal Plant Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Vijay Kumar Thakur
J. Funct. Biomater. 2021, 12(1), 19; https://doi.org/10.3390/jfb12010019
Received: 15 January 2021 / Revised: 22 February 2021 / Accepted: 2 March 2021 / Published: 5 March 2021
(This article belongs to the Special Issue Bioinspired Materials for Medical and Biotechnological Applications)
Unique biosynthetic abilities revealed by plants determine in vitro cultures of hairy roots as a suitable source of pharmaceutically relevant bioactive compounds. The basic aim of the study was to examine the applicability of aerogel composed of methyltrimethoxysilane (MTMS) for immobilization of Rindera graeca hairy roots by identifying quantitative effects of biomass proliferation and naphthoquinones extracellular secretion in the aerogel-supported culture system. R. graeca hairy roots were simultaneously cultured for 28-days, as (i) nonimmobilized biomass (reference system), (ii) biomass immobilized on macroporous polyurethane foam (PUF), (iii) biomass with disintegrated MTMS aerogel, (iv) biomass immobilized on polypropylene (PP) fibers (as control), and (v) biomass immobilized on monolithic PP-reinforced MTMS aerogel. MTMS aerogel exhibited high level of biocompatibility toward R. graeca hairy roots which grew into the structure of monolithic aerogel-based constructs. Monolithic MTMS-based constructs significantly promoted the proliferation of hairy roots, resulting in 55% higher fresh mass than the reference system. The highest level of naphthoquinones productivity, i.e., 653 µg gDW−1, was noted for PUF-supported culture system. View Full-Text
Keywords: MTMS aerogel; naphthoquinones; hairy (transgenic) roots; plant biomass immobilization; polyurethane foam (PUF); in situ extraction MTMS aerogel; naphthoquinones; hairy (transgenic) roots; plant biomass immobilization; polyurethane foam (PUF); in situ extraction
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MDPI and ACS Style

Nowak, B.; Kawka, M.; Wierzchowski, K.; Sykłowska-Baranek, K.; Pilarek, M. MTMS-Based Aerogel Constructs for Immobilization of Plant Hairy Roots: Effects on Proliferation of Rindera graeca Biomass and Extracellular Secretion of Naphthoquinones. J. Funct. Biomater. 2021, 12, 19. https://doi.org/10.3390/jfb12010019

AMA Style

Nowak B, Kawka M, Wierzchowski K, Sykłowska-Baranek K, Pilarek M. MTMS-Based Aerogel Constructs for Immobilization of Plant Hairy Roots: Effects on Proliferation of Rindera graeca Biomass and Extracellular Secretion of Naphthoquinones. Journal of Functional Biomaterials. 2021; 12(1):19. https://doi.org/10.3390/jfb12010019

Chicago/Turabian Style

Nowak, Bartosz, Mateusz Kawka, Kamil Wierzchowski, Katarzyna Sykłowska-Baranek, and Maciej Pilarek. 2021. "MTMS-Based Aerogel Constructs for Immobilization of Plant Hairy Roots: Effects on Proliferation of Rindera graeca Biomass and Extracellular Secretion of Naphthoquinones" Journal of Functional Biomaterials 12, no. 1: 19. https://doi.org/10.3390/jfb12010019

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