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10.3390/jcm8030285
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Article

FABP4 in Gestational Diabetes—Association between Mothers and Offspring

by
Jolanta Patro-Małysza
1,*,
Marcin Trojnar
2,
Żaneta Kimber-Trojnar
1,
Radzisław Mierzyński
1,
Jacek Bartosiewicz
1,
Jan Oleszczuk
1 and
Bożena Leszczyńska-Gorzelak
1
1
Department of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, Poland
2
Department of Internal Medicine, Medical University of Lublin, 20-081 Lublin, Poland
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(3), 285; https://doi.org/10.3390/jcm8030285
Submission received: 29 December 2018 / Revised: 18 February 2019 / Accepted: 22 February 2019 / Published: 27 February 2019
(This article belongs to the Special Issue Diagnosis, Treatment and Prevention of Fetal Diseases and Fetal Risk Factors for Non-Communicable Diseases)
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Abstract

Fetuses exposed to gestational diabetes mellitus (GDM) have a higher risk of abnormal glucose homeostasis in later life. The molecular mechanisms of this phenomenon are still not fully understood. Fatty acid binding protein 4 (FABP4) appears to be one of the most probable candidates involved in the pathophysiology of GDM. The main aim of the study was to investigate whether umbilical cord serum FABP4 concentrations are altered in term neonates born to GDM mothers. Two groups of subjects were selected—28 healthy controls and 26 patients with GDM. FABP4, leptin, and ghrelin concentrations in the umbilical cord serum, maternal serum, and maternal urine were determined via an enzyme-linked immunosorbent assay. The umbilical cord serum FABP4 levels were higher in the GDM offspring and were directly associated with the maternal serum FABP4 and leptin levels, as well as the prepregnancy body mass index (BMI) and the BMI at and after delivery; however, they correlated negatively with birth weight and lipid parameters. In the multiple linear regression models, the umbilical cord serum FABP4 concentrations depended positively on the maternal serum FABP4 and negatively on the umbilical cord serum ghrelin levels and the high-density lipoprotein cholesterol. There are many maternal variables that can affect the level of FABP4 in the umbilical cord serum, thus, their evaluation requires further investigation.
Keywords: gestational diabetes mellitus; fatty acid binding protein 4; neonatal anthropometry; ghrelin; leptin; adipokines gestational diabetes mellitus; fatty acid binding protein 4; neonatal anthropometry; ghrelin; leptin; adipokines

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MDPI and ACS Style

Patro-Małysza, J.; Trojnar, M.; Kimber-Trojnar, Ż.; Mierzyński, R.; Bartosiewicz, J.; Oleszczuk, J.; Leszczyńska-Gorzelak, B. FABP4 in Gestational Diabetes—Association between Mothers and Offspring. J. Clin. Med. 2019, 8, 285. https://doi.org/10.3390/jcm8030285

AMA Style

Patro-Małysza J, Trojnar M, Kimber-Trojnar Ż, Mierzyński R, Bartosiewicz J, Oleszczuk J, Leszczyńska-Gorzelak B. FABP4 in Gestational Diabetes—Association between Mothers and Offspring. Journal of Clinical Medicine. 2019; 8(3):285. https://doi.org/10.3390/jcm8030285

Chicago/Turabian Style

Patro-Małysza, Jolanta, Marcin Trojnar, Żaneta Kimber-Trojnar, Radzisław Mierzyński, Jacek Bartosiewicz, Jan Oleszczuk, and Bożena Leszczyńska-Gorzelak. 2019. "FABP4 in Gestational Diabetes—Association between Mothers and Offspring" Journal of Clinical Medicine 8, no. 3: 285. https://doi.org/10.3390/jcm8030285

APA Style

Patro-Małysza, J., Trojnar, M., Kimber-Trojnar, Ż., Mierzyński, R., Bartosiewicz, J., Oleszczuk, J., & Leszczyńska-Gorzelak, B. (2019). FABP4 in Gestational Diabetes—Association between Mothers and Offspring. Journal of Clinical Medicine, 8(3), 285. https://doi.org/10.3390/jcm8030285

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