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J. Clin. Med. 2019, 8(2), 218; https://doi.org/10.3390/jcm8020218

Spirit-Quieting Traditional Chinese Medicine May Improve Survival in Prostate Cancer Patients with Depression

1
Division of Urology, Department of Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, Taiwan
2
Graduate Institute of Clinical Medical Science, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
3
Department of Chinese Medicine, Taipei City Hospital, Ren-Ai Branch, Taipei 106, Taiwan
4
Institute of Public Health, National Yang-Ming University, Taipei 112, Taiwan
5
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan
6
Cancer Medicine Center of Buddhist Hualien Tzu Chi Hospital, Tzu Chi University, Hualien 970, Taiwan
7
Department of Pathology and Graduate Institute of Pathology and Parasitology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
8
Division of Urology, Department of Surgery, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan 330, Taiwan
9
Department of Medicine, National Yang-Ming University, Taipei 112, Taiwan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 16 January 2019 / Revised: 3 February 2019 / Accepted: 5 February 2019 / Published: 8 February 2019
(This article belongs to the Special Issue Advanced Analytical Methods in Clinical Diagnosis and Therapy)
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Abstract

Depression is associated with higher mortality in prostate cancer. However, whether traditional Chinese medicine (TCM) for depression improves outcomes in patients with prostate cancer is unclear. This retrospective cohort study evaluated the association between TCM for depression and mortality in patients with prostate cancer. During the period 1998–2012, a total of 248 prostate cancer patients in Taiwan with depression were enrolled and divided into three groups: TCM for depression (n = 81, 32.7%), TCM for other purposes (n = 53, 21.3%), and no TCM (n = 114, 46.0%). During a median follow-up of 6.2 years, 12 (14.8%), 13 (24.5%), and 36 (31.6%) deaths occurred in the TCM for depression, TCM for other purposes, and no TCM groups, respectively. After adjusting age at diagnosis, urbanization, insured amount, comorbidity disease, and prostate cancer type, TCM for depression was associated with a significantly lower risk of overall mortality based on a multivariate-adjusted Cox proportional-hazards model (hazard ratio 0.42, 95% confidence interval: 0.21–0.85, p = 0.02) and Kaplan–Meier survival curve (log-rank test, p = 0.0055) compared to no TCM. In conclusion, TCM for depression may have a positive association with the survival of prostate cancer patients with depression. View Full-Text
Keywords: prostate cancer; depression; traditional Chinese medicine prostate cancer; depression; traditional Chinese medicine
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Lin, P.-H.; Lin, S.-K.; Hsu, R.-J.; Pang, S.-T.; Chuang, C.-K.; Chang, Y.-H.; Liu, J.-M. Spirit-Quieting Traditional Chinese Medicine May Improve Survival in Prostate Cancer Patients with Depression. J. Clin. Med. 2019, 8, 218.

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