Splenic Artery Aneurysms, a Rare Complication of Type 1 Gaucher Disease: Report of Five Cases
AbstractType 1 Gaucher disease is a rare genetic lysosomal disorder due to acid betaglucosidase deficiency. The main features are thrombocytopenia, anemia, hepatosplenomegaly and complex skeletal disease. Complications include pulmonary hypertension, cirrhosis and splenic infarction; comorbidities, such as autoimmune phenomena, B-cell malignancies and Parkinson disease also occur. Visceral aneurysms have been only rarely noted in Gaucher disease. We report the retrospective data from patients with Gaucher disease type 1 and splenic arterial aneurysm. We describe the different outcomes of a giant splenic arterial aneurysm in five patients with type 1 Gaucher disease and discuss the main possible pathophysiological explanations. Aneurysms of the splenic artery are rare in Gaucher disease but are probably greatly under-reported. View Full-Text
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Serratrice, C.; Cox, T.M.; Leguy-Seguin, V.; Morris, E.; Yousfi, K.; Monnet, O.; Sibert, A.; Allaham, W.; Belmatoug, N. Splenic Artery Aneurysms, a Rare Complication of Type 1 Gaucher Disease: Report of Five Cases. J. Clin. Med. 2019, 8, 219.
Serratrice C, Cox TM, Leguy-Seguin V, Morris E, Yousfi K, Monnet O, Sibert A, Allaham W, Belmatoug N. Splenic Artery Aneurysms, a Rare Complication of Type 1 Gaucher Disease: Report of Five Cases. Journal of Clinical Medicine. 2019; 8(2):219.Chicago/Turabian Style
Serratrice, Christine; Cox, Timothy M.; Leguy-Seguin, Vanessa; Morris, Elizabeth; Yousfi, Karima; Monnet, Olivier; Sibert, Annie; Allaham, Wassim; Belmatoug, Nadia. 2019. "Splenic Artery Aneurysms, a Rare Complication of Type 1 Gaucher Disease: Report of Five Cases." J. Clin. Med. 8, no. 2: 219.
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