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Journal of Clinical Medicine, Volume 5, Issue 1

January 2016 - 12 articles

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Articles (12)

  • Review
  • Open Access
83 Citations
10,552 Views
23 Pages

19 January 2016

Steroid Nuclear Receptors (SNRs) are transcription factors of the nuclear receptor super-family. Estrogen Receptor (ERα) is the best-studied and has a seminal role in the clinic both as a prognostic marker but also as a predictor of response to anti-...

  • Article
  • Open Access
18 Citations
6,255 Views
9 Pages

Enhanced Efficacy of Doxorubicin by microRNA-499-Mediated Improvement of Tumor Blood Flow

  • Ayaka Okamoto,
  • Tomohiro Asai,
  • Sho Ryu,
  • Hidenori Ando,
  • Noriyuki Maeda,
  • Takehisa Dewa and
  • Naoto Oku

19 January 2016

Genetic therapy using microRNA-499 (miR-499) was combined with chemotherapy for the advanced treatment of cancer. Our previous study showed that miR-499 suppressed tumor growth through the inhibition of vascular endothelial growth factor (VEGF) produ...

  • Feature Paper
  • Review
  • Open Access
104 Citations
11,997 Views
20 Pages

MicroRNA Regulation of Epithelial to Mesenchymal Transition

  • Mohammed L. Abba,
  • Nitin Patil,
  • Jörg Hendrik Leupold and
  • Heike Allgayer

14 January 2016

Epithelial to mesenchymal transition (EMT) is a central regulatory program that is similar in many aspects to several steps of embryonic morphogenesis. In addition to its physiological role in tissue repair and wound healing, EMT contributes to chemo...

  • Feature Paper
  • Review
  • Open Access
44 Citations
6,236 Views
11 Pages

Controversies over the Epithelial-to-Mesenchymal Transition in Liver Fibrosis

  • Kojiro Taura,
  • Keiko Iwaisako,
  • Etsuro Hatano and
  • Shinji Uemoto

14 January 2016

Liver fibrosis is a universal consequence of chronic liver diseases. It is accompanied by activation of collagen-producing myofibroblasts, resulting in excessive deposition of extracellular matrix. The origin of myofibroblasts in the fibrotic liver h...

  • Review
  • Open Access
21 Citations
7,143 Views
17 Pages

12 January 2016

Notwithstanding controversies over the role of epithelial to mesenchymal transition in the pathogenesis of renal disease, the last decade has witnessed a revolution in our understanding of the regulation of renal cell plasticity. Significant parallel...

  • Review
  • Open Access
45 Citations
8,525 Views
19 Pages

12 January 2016

Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) are observed during both physiological liver wound healing and the pathological fibrotic/carcinogenic (fibro-carcinogenetic) process. TGF-β and pro-inflammatory cytok...

  • Review
  • Open Access
102 Citations
34,467 Views
17 Pages

Continuous subcutaneous insulin, or the insulin pump, has gained popularity and sophistication as a near-physiologic programmable method of insulin delivery that is flexible and lifestyle-friendly. The introduction of continuous monitoring with gluco...

  • Review
  • Open Access
73 Citations
9,356 Views
24 Pages

31 December 2015

Adipose tissue function is key determinant of metabolic health, with specific nutrients being suggested to play a role in tissue metabolism. One such group of nutrients are the n-3 fatty acids, specifically eicosapentaenoic acid (EPA; 20:5n-3) and do...

  • Review
  • Open Access
42 Citations
12,922 Views
16 Pages

Pathogenesis of Type 2 Epithelial to Mesenchymal Transition (EMT) in Renal and Hepatic Fibrosis

  • Anusha H. Tennakoon,
  • Takeshi Izawa,
  • Mitsuru Kuwamura and
  • Jyoji Yamate

30 December 2015

Epithelial to mesenchymal transition (EMT), particularly, type 2 EMT, is important in progressive renal and hepatic fibrosis. In this process, incompletely regenerated renal epithelia lose their epithelial characteristics and gain migratory mesenchym...

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J. Clin. Med. - ISSN 2077-0383