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Epithelial–Mesenchymal Transitions during Neural Crest and Somite Development

Edmond and Lili Safra Center for Brain Sciences (ELSC), Department of Medical Neurobiology, Institute for Medical Research Israel-Canada (IMRIC), Hebrew University of Jerusalem-Hadassah Medical School, P.O. Box 12272, Jerusalem 9112102, Israel
Academic Editors: David A. Brenner, Tatiana Kisseleva and Jonas Fuxe
J. Clin. Med. 2016, 5(1), 1;
Received: 24 November 2015 / Revised: 9 December 2015 / Accepted: 14 December 2015 / Published: 25 December 2015
(This article belongs to the Special Issue Epithelial-Mesenchymal Transition)
PDF [1786 KB, uploaded 25 December 2015]


Epithelial-to-mesenchymal transition (EMT) is a central process during embryonic development that affects selected progenitor cells of all three germ layers. In addition to driving the onset of cellular migrations and subsequent tissue morphogenesis, the dynamic conversions of epithelium into mesenchyme and vice-versa are intimately associated with the segregation of homogeneous precursors into distinct fates. The neural crest and somites, progenitors of the peripheral nervous system and of skeletal tissues, respectively, beautifully illustrate the significance of EMT to the above processes. Ongoing studies progressively elucidate the gene networks underlying EMT in each system, highlighting the similarities and differences between them. Knowledge of the mechanistic logic of this normal ontogenetic process should provide important insights to the understanding of pathological conditions such as cancer metastasis, which shares some common molecular themes. View Full-Text
Keywords: BMP; cell fate; cell migration; dermis; dermomyotome; FGF; N-cadherin; neural tube; sclerotome; Wnt BMP; cell fate; cell migration; dermis; dermomyotome; FGF; N-cadherin; neural tube; sclerotome; Wnt

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Kalcheim, C. Epithelial–Mesenchymal Transitions during Neural Crest and Somite Development. J. Clin. Med. 2016, 5, 1.

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