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Article

AMH in Males: Effects of Body Size and Composition on Serum AMH Levels

by
Veronika Tandl
1,
Christoph Haudum
1,
Katharina Eberhard
2,
Barbara Hutz
1,
Ines Foessl
1,
Ewald Kolesnik
3,
Andreas Zirlik
3,
Dirk von Lewinski
3,
Daniel Scherr
3,
Nicolas Verheyen
3,
Thomas Pieber
1 and
Barbara Obermayer-Pietsch
1,*
1
Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria
2
Core Facility Computational Bioanalytics, Medical University Graz, 8036 Graz, Austria
3
Division of Cardiology, Department of Internal Medicine and University Heart Center Graz, Medical University of Graz, 8036 Graz, Austria
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2023, 12(13), 4478; https://doi.org/10.3390/jcm12134478
Submission received: 14 May 2023 / Revised: 28 June 2023 / Accepted: 1 July 2023 / Published: 4 July 2023
(This article belongs to the Special Issue Polycystic Ovary Syndrome: Clinical Diagnosis and Management)
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Abstract

Serum concentrations of anti-Müllerian hormone (AMH) have been found to decrease with increasing body mass index (BMI) in many studies. It is not yet clear whether this stems from an adverse effect of adiposity on AMH production, or from dilution due to the greater blood volume that accompanies a larger body size. To investigate a possible hemodilution effect, we explored the relationships between serum AMH levels and different parameters of body composition using linear regression models in a cohort of adult males. Body weight, lean mass (LM), and body surface area (BSA) were found to be better predictors of AMH than measures of adiposity, such as BMI or fat mass. Since both LM and BSA correlate with plasma volume better than adipose tissue, we conclude that hemodilution of AMH does occur in adult males and should be considered for normalization in future studies.
Keywords: anti-Müllerian hormone; hemodilution; body mass index; body composition anti-Müllerian hormone; hemodilution; body mass index; body composition

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MDPI and ACS Style

Tandl, V.; Haudum, C.; Eberhard, K.; Hutz, B.; Foessl, I.; Kolesnik, E.; Zirlik, A.; von Lewinski, D.; Scherr, D.; Verheyen, N.; et al. AMH in Males: Effects of Body Size and Composition on Serum AMH Levels. J. Clin. Med. 2023, 12, 4478. https://doi.org/10.3390/jcm12134478

AMA Style

Tandl V, Haudum C, Eberhard K, Hutz B, Foessl I, Kolesnik E, Zirlik A, von Lewinski D, Scherr D, Verheyen N, et al. AMH in Males: Effects of Body Size and Composition on Serum AMH Levels. Journal of Clinical Medicine. 2023; 12(13):4478. https://doi.org/10.3390/jcm12134478

Chicago/Turabian Style

Tandl, Veronika, Christoph Haudum, Katharina Eberhard, Barbara Hutz, Ines Foessl, Ewald Kolesnik, Andreas Zirlik, Dirk von Lewinski, Daniel Scherr, Nicolas Verheyen, and et al. 2023. "AMH in Males: Effects of Body Size and Composition on Serum AMH Levels" Journal of Clinical Medicine 12, no. 13: 4478. https://doi.org/10.3390/jcm12134478

APA Style

Tandl, V., Haudum, C., Eberhard, K., Hutz, B., Foessl, I., Kolesnik, E., Zirlik, A., von Lewinski, D., Scherr, D., Verheyen, N., Pieber, T., & Obermayer-Pietsch, B. (2023). AMH in Males: Effects of Body Size and Composition on Serum AMH Levels. Journal of Clinical Medicine, 12(13), 4478. https://doi.org/10.3390/jcm12134478

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