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Membranes, Volume 9, Issue 12 (December 2019) – 17 articles
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Cover Story (view full-size image) Measles virus (MV) has gained broad interest due to its effectiveness in treating late-stage [...] Read more. Measles virus (MV) has gained broad interest due to its effectiveness in treating late-stage cancer. For cancer therapy, at least 108 infectious MV particles per dose with a defined purity are needed. A typical unit operation to concentrate viruses is tangential flow filtration (TFF). In this study, we successfully concentrated MV by TFF and determined the effect of cell culture media and membrane properties (cut-offs and materials). We conducted a fouling analysis and found correlations among membrane fouling, virus recovery, and impurity depletion. View this paper