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Electrospun Polycaprolactone Fibrous Membranes Containing Ag, TiO2 and Na2Ti6O13 Particles for Potential Use in Bone Regeneration

1
Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Av. Eugenio Garza Sada #2501 Sur, Monterrey, NL 64849, Mexico
2
Laboratorio Nacional de Manufatura Aditiva y Digital (MADIT), Autopista al Aeropuerto, Km., 9.5, Calle Alianza Norte #100, Parque PIIT, Apodaca, NL 66629, Mexico
3
Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Vía Atlixcáyotl 2301, Reserva Territorial Atlixcáyotl, Puebla, PUE 72453, Mexico
*
Author to whom correspondence should be addressed.
Membranes 2019, 9(1), 12; https://doi.org/10.3390/membranes9010012
Received: 1 December 2018 / Revised: 19 December 2018 / Accepted: 3 January 2019 / Published: 10 January 2019
(This article belongs to the Special Issue Electrospun Nanofiber Membranes: Advances and Applications)
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Abstract

Biocompatible and biodegradable membrane treatments for regeneration of bone are nowadays a promising solution in the medical field. Bioresorbable polymers are extensively used in membrane elaboration, where polycaprolactone (PCL) is used as base polymer. The goal of this work was to improve electrospun membranes’ biocompatibility and antibacterial properties by adding micro- and nanoparticles such as Ag, TiO2 and Na2Ti6O13. Micro/nanofiber morphologies of the obtained membranes were characterized by X-ray diffraction, Fourier-transform infrared spectroscopy, differential scanning calorimetry, scanning electron microscopy, energy-dispersive X-ray spectroscopy and a tensile test. Also, for this study optical microscopy was used to observe DAPI-stained cells. Membranes of the different systems were electrospun to an average diameter of 1.02–1.76 μm. To evaluate the biological properties, cell viability was studied by growing NIH/3T3 cells on the microfibers. PCL/TiO2 strength was enhanced from 0.6 MPa to 6.3 MPa in comparison with PCL without particles. Antibacterial activity was observed in PCL/TiO2 and PCL/Na2Ti6O13 electrospun membranes using Staphylococcus aureus bacteria. Bioactivity of the membranes was confirmed with simulated body fluid (SBF) treatment. From this study, the ceramic particles TiO2 and Na2Ti6O13, combined with a PCL matrix with micro/nanoparticles, enhanced cell proliferation, adhesion and antibacterial properties. The electrospun composite with Na2Ti6O13 can be considered viable for tissue regenerative processes. View Full-Text
Keywords: electrospinning; antibacterial; cell proliferation; bioactivity; polycaprolactone; titanium dioxide; silver; sodium hexatitanate electrospinning; antibacterial; cell proliferation; bioactivity; polycaprolactone; titanium dioxide; silver; sodium hexatitanate
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Ramírez-Cedillo, E.; Ortega-Lara, W.; Rocha-Pizaña, M.R.; Gutierrez-Uribe, J.A.; Elías-Zúñiga, A.; Rodríguez, C.A. Electrospun Polycaprolactone Fibrous Membranes Containing Ag, TiO2 and Na2Ti6O13 Particles for Potential Use in Bone Regeneration. Membranes 2019, 9, 12.

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