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Membranes 2019, 9(1), 11; https://doi.org/10.3390/membranes9010011

Preparation and Properties of Carboxymethyl Chitosan/Alginate/Tranexamic Acid Composite Films

1
School of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, China
2
Agricultural Product Processing Research Institute, Chinese Academy of Tropical agricultural Sciences, Zhanjiang 524001, China
*
Authors to whom correspondence should be addressed.
Received: 4 December 2018 / Revised: 1 January 2019 / Accepted: 4 January 2019 / Published: 8 January 2019
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Abstract

In this study, the porous composite films of carboxymethyl chitosan/alginate/tranexamic acid were fabricated, with calcium chloride as the crosslinking agent and glycerin as a plasticizer. The composite films were characterized by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. The properties of the composite films, including water absorption, air permeability, and cumulative release rate, were tested. In addition, their hemostatic performance was evaluated. The results showed that the appearance of the films with good adhesion was smooth and porous. FTIR showed that chemical crosslinking between carboxymethyl chitosan and sodium alginate was successful. The excellent cumulative release of tranexamic acid in the composite films (60–80%) gives the films a significant procoagulant effect. This has good prospects for the development of medical hemostasis materials. View Full-Text
Keywords: carboxymethyl chitosan; sodium alginate; tranexamic acid; composite films; hemostatic activity carboxymethyl chitosan; sodium alginate; tranexamic acid; composite films; hemostatic activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Zhong, Q.-K.; Wu, Z.-Y.; Qin, Y.-Q.; Hu, Z.; Li, S.-D.; Yang, Z.-M.; Li, P.-W. Preparation and Properties of Carboxymethyl Chitosan/Alginate/Tranexamic Acid Composite Films. Membranes 2019, 9, 11.

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