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Antioxidants
Volume 9
Issue 1
10.3390/antiox9010048
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Review

Curcumin as a Therapeutic Option in Retinal Diseases

by
Daniel López-Malo
1,
Carlos Alberto Villarón-Casares
1,
Jorge Alarcón-Jiménez
2,
Maria Miranda
3,
Manuel Díaz-Llopis
4,
Francisco J. Romero
1,5,* and
Vincent M. Villar
3
1
Facultad de Ciencias de la Salud, Universidad Europea de Valencia, 46010 Valencia, Spain
2
Facultad de Medicina y Ciencias de la Salud, Universidad Católica de Valencia, 46001 Valencia, Spain
3
Facultad de Ciencias de la Salud, Universidad CEU Cardenal Herrera, 46315 Moncada, Spain
4
Facultad de Medicina y Odontología, Universitat de Valencia, 46010 Valencia, Spain
5
Hospital General de Requena, Conselleria de Sanitat, Generalitat Valenciana, 46340 Valencia, Spain
*
Author to whom correspondence should be addressed.
Antioxidants 2020, 9(1), 48; https://doi.org/10.3390/antiox9010048
Submission received: 22 November 2019 / Revised: 27 December 2019 / Accepted: 29 December 2019 / Published: 6 January 2020
(This article belongs to the Special Issue Natural Products in Health Promotion and Disease Prevention)
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Abstract

The retina is subjected to oxidative stress due to its high vascularization, long time light exposition and a high density of mitochondria. Oxidative stress can lead to pathological processes, like cell apoptosis, angiogenesis and inflammation ending in retinal pathologies. Curcumin, a major bioactive component obtained from the spice turmeric (Curcuma longa) rhizome has been used for centuries in Asian countries for cooking and for curing all kinds of diseases like dysentery, chest congestion and pain in general, due to its antioxidant effects. Curcumin prevents the formation of reactive oxygen species and so it is a good protective agent. Curcumin has shown also anti-inflammatory, and antitumor properties. Curcumin is a natural product, which can be a therapeutic option in a variety of retinal diseases due to its pleiotropic properties. Some drawbacks are its poor solubility, bioavailability and lack of stability at physiological conditions; which have been shown in curcumin skeptical publications. In this review, we provide some lights and shadows on curcumin administration on the major retinal pathologies.
Keywords: curcumin; oxidative stress; retina; retinal diseases curcumin; oxidative stress; retina; retinal diseases

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MDPI and ACS Style

López-Malo, D.; Villarón-Casares, C.A.; Alarcón-Jiménez, J.; Miranda, M.; Díaz-Llopis, M.; Romero, F.J.; Villar, V.M. Curcumin as a Therapeutic Option in Retinal Diseases. Antioxidants 2020, 9, 48. https://doi.org/10.3390/antiox9010048

AMA Style

López-Malo D, Villarón-Casares CA, Alarcón-Jiménez J, Miranda M, Díaz-Llopis M, Romero FJ, Villar VM. Curcumin as a Therapeutic Option in Retinal Diseases. Antioxidants. 2020; 9(1):48. https://doi.org/10.3390/antiox9010048

Chicago/Turabian Style

López-Malo, Daniel, Carlos Alberto Villarón-Casares, Jorge Alarcón-Jiménez, Maria Miranda, Manuel Díaz-Llopis, Francisco J. Romero, and Vincent M. Villar. 2020. "Curcumin as a Therapeutic Option in Retinal Diseases" Antioxidants 9, no. 1: 48. https://doi.org/10.3390/antiox9010048

APA Style

López-Malo, D., Villarón-Casares, C. A., Alarcón-Jiménez, J., Miranda, M., Díaz-Llopis, M., Romero, F. J., & Villar, V. M. (2020). Curcumin as a Therapeutic Option in Retinal Diseases. Antioxidants, 9(1), 48. https://doi.org/10.3390/antiox9010048

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