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Open AccessArticle

Effect of Acacia Polyphenol Supplementation on Exercise-Induced Oxidative Stress in Mice Liver and Skeletal Muscle

1
Faculty of Sport Sciences, Waseda University, Tokorozawa, Saitama 359-1192, Japan
2
School of Allied Health Sciences, Griffith University, Gold Coast 4215, Australia
3
School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane 4072, Australia
4
Graduate School of Sport Sciences, Waseda University, Tokorozawa, Saitama 359-1192, Japan
*
Author to whom correspondence should be addressed.
Antioxidants 2020, 9(1), 29; https://doi.org/10.3390/antiox9010029
Received: 7 November 2019 / Revised: 16 December 2019 / Accepted: 25 December 2019 / Published: 28 December 2019
(This article belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)
The purpose of this study was to investigate the effects of acacia polyphenol (AP) supplementation on exercise-induced oxidative stress in mouse liver and skeletal muscle. Plasma aspartate aminotransferase (AST), liver and skeletal muscle levels of thiobarbituric acid reactive substance (TBARS), and levels of skeletal muscle protein carbonyls increased immediately after exhaustive exercise. Exhaustive exercise also decreased liver glutathione (GSH). These results suggest that the exhaustive exercise used in this study induced tissue damage and oxidative stress. Contrary to our expectations, AP supplementation increased plasma AST and alanine aminotransferase activities, liver levels of TBARS, and protein carbonyls. Furthermore, AP supplementation decreased glutathione and glutathione peroxidase activity in the liver. On the other hand, AP supplementation decreased TBARS levels in skeletal muscle. These results suggest that oral high-dose AP administration decreased oxidative stress in skeletal muscle but induced oxidative stress in the liver and increased hepatotoxicity. View Full-Text
Keywords: polyphenols; antioxidants; oxidative stress; hepatotoxicity; exhaustive exercise polyphenols; antioxidants; oxidative stress; hepatotoxicity; exhaustive exercise
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Yada, K.; Roberts, L.A.; Oginome, N.; Suzuki, K. Effect of Acacia Polyphenol Supplementation on Exercise-Induced Oxidative Stress in Mice Liver and Skeletal Muscle. Antioxidants 2020, 9, 29.

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