Next Article in Journal
Effects of Storage Time and Temperature on Lipid Oxidation and Protein Co-Oxidation of Low-Moisture Shredded Meat Products
Next Article in Special Issue
Sideritis Perfoliata (Subsp. Perfoliata) Nutritive Value and Its Potential Medicinal Properties
Previous Article in Journal
Anti-Oxidized LDL Antibodies and Coronary Artery Disease: A Systematic Review
Previous Article in Special Issue
In Vitro Toxicity Assessment of Stilbene Extract for Its Potential Use as Antioxidant in the Wine Industry
Open AccessArticle

Methyl Jasmonate Reduces Inflammation and Oxidative Stress in the Brain of Arthritic Rats

1
Department of Biochemistry, University of Maringá, 7020900 Maringá, Brazil
2
Department of Pharmacology and Therapeutics, University of Maringá, 87020900 Maringá, Brazil
*
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(10), 485; https://doi.org/10.3390/antiox8100485
Received: 10 July 2019 / Revised: 2 October 2019 / Accepted: 4 October 2019 / Published: 15 October 2019
Methyl jasmonate (MeJA), common in the plant kingdom, is capable of reducing articular and hepatic inflammation and oxidative stress in adjuvant-induced arthritic rats. This study investigated the actions of orally administered MeJA (75–300 mg/kg) on inflammation, oxidative stress and selected enzyme activities in the brain of Holtzman rats with adjuvant-induced arthritis. MeJA prevented the arthritis-induced increased levels of nitrites, nitrates, lipid peroxides, protein carbonyls and reactive oxygen species (ROS). It also prevented the enhanced activities of myeloperoxidase and xanthine oxidase. Conversely, the diminished catalase and superoxide dismutase activities and glutathione (GSH) levels caused by arthritis were totally or partially prevented. Furthermore, MeJA increased the activity of the mitochondrial isocitrate dehydrogenase, which helps to supply NADPH for the mitochondrial glutathione cycle, possibly contributing to the partial recovery of the GSH/oxidized glutathione (GSSG) ratio. These positive actions on the antioxidant defenses may counterbalance the effects of MeJA as enhancer of ROS production in the mitochondrial respiratory chain. A negative effect of MeJA is the detachment of hexokinase from the mitochondria, which can potentially impair glucose phosphorylation and metabolism. In overall terms, however, it can be concluded that MeJA attenuates to a considerable extent the negative effects caused by arthritis in terms of inflammation and oxidative stress. View Full-Text
Keywords: adjuvant-induced arthritis; rheumatoid arthritis; methyl jasmonate; brain mitochondria; hexokinase; oxidative stress adjuvant-induced arthritis; rheumatoid arthritis; methyl jasmonate; brain mitochondria; hexokinase; oxidative stress
Show Figures

Figure 1

MDPI and ACS Style

Pereira-Maróstica, H.V.; Castro, L.S.; Gonçalves, G.A.; Silva, F.M.; Bracht, L.; Bersani-Amado, C.A.; Peralta, R.M.; Comar, J.F.; Bracht, A.; Sá-Nakanishi, A.B. Methyl Jasmonate Reduces Inflammation and Oxidative Stress in the Brain of Arthritic Rats. Antioxidants 2019, 8, 485.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop