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Antioxidants
Volume 14
Issue 8
10.3390/antiox14080998
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

Cyclodextrin-Based Delivery Systems for Flavonoids: Mechanisms, Advances, Formulation, and Application Opportunities

by
Ferenc Fenyvesi
1,
Ágnes Klusóczki
2,
Ágnes Rusznyák
1,
Barbara Zsebik
3,
Ildikó Bácskay
2 and
Judit Váradi
2,*
1
Department of Molecular and Nanopharmaceutics, Faculty of Pharmacy, University of Debrecen, H-4002 Debrecen, Hungary
2
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, H-4002 Debrecen, Hungary
3
Department of Biopharmacy, Faculty of Pharmacy, University of Debrecen, H-4002 Debrecen, Hungary
*
Author to whom correspondence should be addressed.
Antioxidants 2025, 14(8), 998; https://doi.org/10.3390/antiox14080998 (registering DOI)
Submission received: 18 July 2025 / Revised: 2 August 2025 / Accepted: 7 August 2025 / Published: 14 August 2025
(This article belongs to the Special Issue Innovations in Drug Delivery Systems for Antioxidant-Based Therapeutic Agents)
Versions Notes

Abstract

Flavonoids play an important role in preventive and therapeutic research due to their significant antioxidant properties. However, their application is limited by several pharmacokinetic drawbacks, such as poor water solubility and low bioavailability. Cyclodextrin-based delivery systems offer an opportunity to overcome these disadvantages. Cyclodextrins are able to form stable, water-soluble inclusion complexes with flavonoids, thereby improving their solubility, chemical stability, and antioxidant activity. This review summarizes the structural characteristics and complexation mechanisms of various flavonoid–cyclodextrin complexes and examines how these interactions influence biological activity. Special attention is given to nanotechnological formulations—such as liposomes, nanofibers, and nanosponges—that enable targeted drug delivery and enhanced therapeutic efficacy. The aim of this review is to provide a comprehensive overview of the role of cyclodextrin-based carriers in the formulation of flavonoids and to highlight the future potential of these systems in modern therapeutics and functional product development.
Keywords: flavonoids; cyclodextrin; antioxidant; flavonoid–cyclodextrin complexes flavonoids; cyclodextrin; antioxidant; flavonoid–cyclodextrin complexes

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MDPI and ACS Style

Fenyvesi, F.; Klusóczki, Á.; Rusznyák, Á.; Zsebik, B.; Bácskay, I.; Váradi, J. Cyclodextrin-Based Delivery Systems for Flavonoids: Mechanisms, Advances, Formulation, and Application Opportunities. Antioxidants 2025, 14, 998. https://doi.org/10.3390/antiox14080998

AMA Style

Fenyvesi F, Klusóczki Á, Rusznyák Á, Zsebik B, Bácskay I, Váradi J. Cyclodextrin-Based Delivery Systems for Flavonoids: Mechanisms, Advances, Formulation, and Application Opportunities. Antioxidants. 2025; 14(8):998. https://doi.org/10.3390/antiox14080998

Chicago/Turabian Style

Fenyvesi, Ferenc, Ágnes Klusóczki, Ágnes Rusznyák, Barbara Zsebik, Ildikó Bácskay, and Judit Váradi. 2025. "Cyclodextrin-Based Delivery Systems for Flavonoids: Mechanisms, Advances, Formulation, and Application Opportunities" Antioxidants 14, no. 8: 998. https://doi.org/10.3390/antiox14080998

APA Style

Fenyvesi, F., Klusóczki, Á., Rusznyák, Á., Zsebik, B., Bácskay, I., & Váradi, J. (2025). Cyclodextrin-Based Delivery Systems for Flavonoids: Mechanisms, Advances, Formulation, and Application Opportunities. Antioxidants, 14(8), 998. https://doi.org/10.3390/antiox14080998

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