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Article

Cimicifuga racemosa Extract Ze 450 Re-Balances Energy Metabolism and Promotes Longevity

1
Biochemical-Pharmacological Center (BPC), Institute of Pharmacology and Clinical Pharmacy, University of Marburg, Karl-von-Frisch-Strasse 2, 35043 Marburg, Germany
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Center for Mind, Brain and Behavior, Hans-Meerwein-Strasse 6, 35032 Marburg, Germany
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Preclinical Research, Max Zeller Soehne AG, 48590 Romanshorn, Switzerland
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Biomedical Research Center Seltersberg (BFS), Laboratory for Nutrition in Prevention and Therapy, Institute of Nutritional Sciences, Justus-Liebig-University of Giessen, Schubertstr. 81, 35392 Giessen, Germany
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Biochemical-Pharmacological Center (BPC), Institute of Pharmacology, University of Marburg, Karl-von-Frisch-Strasse 2, 35043 Marburg, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Chiara Mozzini
Antioxidants 2021, 10(9), 1432; https://doi.org/10.3390/antiox10091432
Received: 19 July 2021 / Revised: 28 August 2021 / Accepted: 31 August 2021 / Published: 8 September 2021
(This article belongs to the Special Issue Oxidative Stress in Chronic and Age-Related Diseases)
Recently, we reported that the Cimicifuga racemosa extract Ze 450 mediated protection from oxidative cell damage through a metabolic shift from oxidative phosphorylation to glycolysis. Here, we investigated the molecular mechanisms underlying the effects of Ze 450 against ferroptosis in neuronal cells, with a particular focus on mitochondria. The effects of Ze 450 on respiratory complex activity and hallmarks of ferroptosis were studied in isolated mitochondria and in cultured neuronal cells, respectively. In addition, Caenorhabditis elegans served as a model organism to study mitochondrial damage and longevity in vivo. We found that Ze 450 directly inhibited complex I activity in mitochondria and enhanced the metabolic shift towards glycolysis via cMyc and HIF1α regulation. The protective effects against ferroptosis were mediated independently of estrogen receptor activation and were distinct from effects exerted by metformin. In vivo, Ze 450 protected C. elegans from the mitochondrial toxin paraquat and promoted longevity in a dose-dependent manner. In conclusion, Ze 450 mediated a metabolic shift to glycolysis via direct effects on mitochondria and altered cell signaling, thereby promoting sustained cellular resilience to oxidative stress in vitro and in vivo. View Full-Text
Keywords: black cohosh; Cimicifuga racemosa; mitochondria; metformin; oxidative stress; longevity black cohosh; Cimicifuga racemosa; mitochondria; metformin; oxidative stress; longevity
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MDPI and ACS Style

Rabenau, M.; Dillberger, B.; Günther, M.; Krippner, S.; Butterweck, V.; Boonen, G.; Drewe, J.; Eckert, G.P.; Culmsee, C. Cimicifuga racemosa Extract Ze 450 Re-Balances Energy Metabolism and Promotes Longevity. Antioxidants 2021, 10, 1432. https://doi.org/10.3390/antiox10091432

AMA Style

Rabenau M, Dillberger B, Günther M, Krippner S, Butterweck V, Boonen G, Drewe J, Eckert GP, Culmsee C. Cimicifuga racemosa Extract Ze 450 Re-Balances Energy Metabolism and Promotes Longevity. Antioxidants. 2021; 10(9):1432. https://doi.org/10.3390/antiox10091432

Chicago/Turabian Style

Rabenau, Malena, Benjamin Dillberger, Madeline Günther, Sylvia Krippner, Veronika Butterweck, Georg Boonen, Jürgen Drewe, Gunter P. Eckert, and Carsten Culmsee. 2021. "Cimicifuga racemosa Extract Ze 450 Re-Balances Energy Metabolism and Promotes Longevity" Antioxidants 10, no. 9: 1432. https://doi.org/10.3390/antiox10091432

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