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Open AccessArticle

Atypical Electrophysiological Indices of Eyes-Open and Eyes-Closed Resting-State in Children and Adolescents with ADHD and Autism

1
Division of Psychiatry and Applied Psychology, School of Medicine, University of Nottingham, Institute of Mental Health, Innovation Park, Triumph Road, Nottingham NG7 2TU, UK
2
NIHR MindTech Healthcare Technology Co-Operative, Institute of Mental Health, Innovation Park, Triumph Road, Nottingham NG7 2TU, UK
*
Author to whom correspondence should be addressed.
Brain Sci. 2020, 10(5), 272; https://doi.org/10.3390/brainsci10050272
Received: 7 April 2020 / Revised: 23 April 2020 / Accepted: 24 April 2020 / Published: 1 May 2020
(This article belongs to the Special Issue New Advances in Attention Deficit Hyperactivity Disorder (ADHD))
Investigating electrophysiological measures during resting-state might be useful to investigate brain functioning and responsivity in individuals under diagnostic assessment for attention deficit hyperactivity disorder (ADHD) and autism. EEG was recorded in 43 children with or without ADHD and autism, during a 4-min-long resting-state session which included an eyes-closed and an eyes-open condition. We calculated and analyzed occipital absolute and relative spectral power in the alpha frequency band (8–12 Hz), and alpha reactivity, conceptualized as the difference in alpha power between eyes-closed and eyes-open conditions. Alpha power was increased during eyes-closed compared to eyes-open resting-state. While absolute alpha power was reduced in children with autism, relative alpha power was reduced in children with ADHD, especially during the eyes-closed condition. Reduced relative alpha reactivity was mainly associated with lower IQ and not with ADHD or autism. Atypical brain functioning during resting-state seems differently associated with ADHD and autism, however further studies replicating these results are needed; we therefore suggest involving research groups worldwide by creating a shared and publicly available repository of resting-state EEG data collected in people with different psychological, psychiatric, or neurodevelopmental conditions, including ADHD and autism. View Full-Text
Keywords: ADHD; autism; resting-state; EEG; alpha; alpha reactivity ADHD; autism; resting-state; EEG; alpha; alpha reactivity
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  • Externally hosted supplementary file 1
    Doi: 10.17605/OSF.IO/AZKHS
    Link: https://osf.io/azkhs/
    Description: Shared database
MDPI and ACS Style

Bellato, A.; Arora, I.; Kochhar, P.; Hollis, C.; Groom, M.J. Atypical Electrophysiological Indices of Eyes-Open and Eyes-Closed Resting-State in Children and Adolescents with ADHD and Autism. Brain Sci. 2020, 10, 272.

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