Effect of Mechanobiology of Cell Response on Titanium with Multilayered Aluminum Nitride/Tantalum Thin Film
by
Mao-Suan Huang 1,2, Shang-Yang Yu 1,†, Pao-Chang Chiang 3,4, Bai-Hung Huang 5,6, Takashi Saito 7
, Chien-Chia Huang 7, Fang-Tzu Pai 8, Chia-Yu Wu 3,9,* and Wen-Chien Lan 10,*
Mao-Suan Huang 1,2, Shang-Yang Yu 1,†, Pao-Chang Chiang 3,4, Bai-Hung Huang 5,6, Takashi Saito 7, Chien-Chia Huang 7, Fang-Tzu Pai 8, Chia-Yu Wu 3,9,* and Wen-Chien Lan 10,*
1
Department of Dentistry, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan
2
School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan
3
School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan
4
Dental Department of Wan-Fang Hospital, Taipei Medical University, Taipei 116, Taiwan
5
Asia Pacific Laser Institute, New Taipei City 220, Taiwan
6
Implant Academy of Minimally Invasive Dentistry, Taipei 106, Taiwan
7
Division of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido 061-0293, Japan
8
School of Dental Technology, Taipei Medical University, Taipei 110, Taiwan
9
Division of Oral and Maxillofacial Surgery, Department of Dentistry, Taipei Medical University Hospital, Taipei 110, Taiwan
10
Department of Oral Hygiene Care, Ching Kuo Institute of Management and Health, Keelung 203, Taiwan
*
Authors to whom correspondence should be addressed.
†
Co-first author: Shang-Yang Yu.
Appl. Sci. 2020, 10(2), 645; https://doi.org/10.3390/app10020645
Received: 19 November 2019 / Revised: 31 December 2019 / Accepted: 13 January 2020 / Published: 16 January 2020
(This article belongs to the Special Issue Application of the Biocomposite Materials on Bone Reconstruction)
In the present study, the piezoelectric aluminum nitride (AlN)/tantalum (Ta) (PAT) thin film was investigated as a biocompatible film and osseointegrated with biomedical devices such as implants. The stress variation on the interaction of cells with the PAT surface was investigated using osteoblast-like cells (MG-63) and fibroblast cells (NIH3T3). A singular behavior was observed on the PAT film with a (002) texture, in which the MG-63 cells were more dispersed and displayed longer and more filopodia than the NIH3T3 cells. Moreover, the MG-63 cells showed ingrowth, adherence, and proliferation on the PAT film surface. The MG-63 cells had more obvious stress variation than the NIH3T3 cells in the differentiation and proliferation. The mechanobiological reaction to cell differentiation and proliferation not only caused osseointegration, but also reduced the surface activation energy, thus enhancing bone remodeling. The formation of a nanopolycrystalline PAT film is believed to enhance the mechanobiological effect, promoting osseointegration.
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MDPI and ACS Style
Huang, M.-S.; Yu, S.-Y.; Chiang, P.-C.; Huang, B.-H.; Saito, T.; Huang, C.-C.; Pai, F.-T.; Wu, C.-Y.; Lan, W.-C. Effect of Mechanobiology of Cell Response on Titanium with Multilayered Aluminum Nitride/Tantalum Thin Film. Appl. Sci. 2020, 10, 645.
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