Table of Contents
Behav. Sci., Volume 9, Issue 6 (June 2019)
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Cover Story (view full-size image) Autism spectrum disorder (ASD) is characterized by persistent deficits in social communication and [...] Read more. Autism spectrum disorder (ASD) is characterized by persistent deficits in social communication and restricted repetitive patterns of behaviors, interests, or activities. Pro-inflammatory events and immune system dysfunctions are cellular or molecular events associated with ASD. Language and speech issues are key components of ASD symptoms that current therapies find difficult to face. Immunological alterations are involved in the development of the lack of speech. The speech-stimulating substances methylcobalamin, tetrahydrobiopterin, folinic acid, omega-3 polyunsaturated fatty acids, flavonoids, corticosteroids, and other metabolites have shown effectiveness in increasing speech ability in ASD subjects. The use of these substances is encouraged by their limited side effects and by their convenient administration through the oral route, with safe dosage ranges. Knowing their pharmacological mechanisms of action and their effects on dysregulated inflammatory responses could lead to a be