You are currently viewing a new version of our website. To view the old version click .

Medical Sciences, Volume 8, Issue 1

March 2020 - 18 articles

Cover Story: Breast cancer is the most commonly occurring cancer in women. At the molecular level, breast cancer is a heterogeneous disease characterized by high genomic instability, as evidenced by somatic gene mutations, copy number alterations, and chromosome structural rearrangements. This genomic instability is caused by defects in DNA damage repair, transcription, and DNA replication. Breast cancers are subdivided in subtypes according to their molecular features, such as the activation of hormone receptors (estrogen and progesterone receptors) of HER2 and/or BRCA mutations. While early-stage breast cancer is a curable disease in about 70% of patients, advanced breast cancer is largely incurable. However, molecular studies have contributed to developing new therapeutic approaches targeting HER2, CDK4/6, PI3K. View this paper.
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (18)

  • Article
  • Open Access
29 Citations
5,431 Views
13 Pages

Exercise-Induced Oxygen Desaturation during the 6-Minute Walk Test

  • Raghav Gupta,
  • Gregg L. Ruppel and
  • Joseph Roland D. Espiritu

31 January 2020

The 6-minute walk test (6MWT) is not intended to document oxygen (O2) desaturation during exertion but is often used for this purpose. Because of this, it only has modest reproducibility in determining the need for ambulatory O2 therapy in patients w...

  • Review
  • Open Access
29 Citations
8,612 Views
12 Pages

The Potential Role of Astrocytes in Parkinson’s Disease (PD)

  • Hiluf Hindeya Gebreyesus and
  • Teklu Gebrehiwot Gebremichael

27 January 2020

Astrocytes are multi-functional cells, now recognized as critical participants in many brain functions. They play a critical physiological role in the clearance of neurotransmitters, such as glutamate and gamma-aminobutyric acid (GABA), and in the re...

  • Article
  • Open Access
3 Citations
4,575 Views
10 Pages

25 January 2020

(1) Background: Present methods for drug susceptibility tests (DST) rely on culture methods that are sophisticated and relatively faster, or a slow and cheaper option. These methods frustrate disease control; therefore, there is a need for methods th...

  • Article
  • Open Access
11 Citations
6,788 Views
14 Pages

Defining Community-Acquired Pneumonia as a Public Health Threat: Arguments in Favor from Spanish Investigators

  • Catia Cillóniz,
  • Rosario Menéndez,
  • Carolina García-Vidal,
  • Juan Manuel Péricas and
  • Antoni Torres

25 January 2020

Despite advances in its prevention, pneumonia remains associated with high morbidity, mortality, and health costs worldwide. Studies carried out in the last decade have indicated that more patients with community-acquired pneumonia (CAP) now require...

  • Article
  • Open Access
19 Citations
6,363 Views
11 Pages

The Presence of Immature GV− Stage Oocytes during IVF/ICSI Is a Marker of Poor Oocyte Quality: A Pilot Study

  • Pia Astbury,
  • Goutham N. Subramanian,
  • Jessica Greaney,
  • Chris Roling,
  • Jacqui Irving and
  • Hayden A. Homer

16 January 2020

Here we investigate whether the presence of germinal vesicle-stage oocytes (GV− oocytes) reflects poor oocyte developmental competence (or quality). This was a prospective, non-randomised, cohort pilot-study involving 60 patients undergoing in...

  • Editorial
  • Open Access
3 Citations
3,026 Views
3 Pages

6 January 2020

Metabolic syndrome (MetS), also termed insulin resistance syndrome, has been defined by World Health Organization (WHO) as a multi-factorial disorder characterized by a wide array of cardiometabolic risk factors that increase the risk of coronary hea...

  • Article
  • Open Access
7 Citations
5,086 Views
20 Pages

29 December 2019

As the leading cause of cancer death worldwide, lung cancer (LC) has seriously affected human health and longevity. Chinese medicine is a complex system guided by traditional Chinese medicine theories (TCM). Nowadays, the clinical application of TCM...

of 2

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Med. Sci. - ISSN 2076-3271