- Editorial
2,370 Views
2 Pages
It is with great pleasure and enthusiasm that we present to you this Special Issue of Medical Sciences [...]
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Medical Sciences, Volume 8, Issue 1
March 2020 - 18 articles
Cover Story: Breast cancer is the most commonly occurring cancer in women. At the molecular level, breast cancer is a heterogeneous disease characterized by high genomic instability, as evidenced by somatic gene mutations, copy number alterations, and chromosome structural rearrangements. This genomic instability is caused by defects in DNA damage repair, transcription, and DNA replication. Breast cancers are subdivided in subtypes according to their molecular features, such as the activation of hormone receptors (estrogen and progesterone receptors) of HER2 and/or BRCA mutations. While early-stage breast cancer is a curable disease in about 70% of patients, advanced breast cancer is largely incurable. However, molecular studies have contributed to developing new therapeutic approaches targeting HER2, CDK4/6, PI3K. View this paper.
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Articles (18)
- Review
157 Citations
16,010 Views
103 Pages
Breast Cancer: A Molecularly Heterogenous Disease Needing Subtype-Specific Treatments
- Ugo Testa,
- Germana Castelli and
- Elvira Pelosi
Breast cancer is the most commonly occurring cancer in women. There were over two-million new cases in world in 2018. It is the second leading cause of death from cancer in western countries. At the molecular level, breast cancer is a heterogeneous d...
- Feature Paper
- Article
7 Citations
4,315 Views
11 Pages
Feasibility of Telephone Follow-Up after Critical Care Discharge
- Sofia Hodalova,
- Sarah Moore,
- Joanne Dowds,
- Niamh Murphy,
- Ignacio Martin-Loeches and
- Julie Broderick
Background: Critical care has evolved from a primary focus on short-term survival, with greater attention being placed on longer-term health care outcomes. It is not known how best to implement follow-up after critical care discharge. Study aims were...
- Review
752 Citations
34,282 Views
12 Pages
Epidemiology of Bladder Cancer
- Kalyan Saginala,
- Adam Barsouk,
- John Sukumar Aluru,
- Prashanth Rawla,
- Sandeep Anand Padala and
- Alexander Barsouk
Based on the latest GLOBOCAN data, bladder cancer accounts for 3% of global cancer diagnoses and is especially prevalent in the developed world. In the United States, bladder cancer is the sixth most incident neoplasm. A total of 90% of bladder cance...
- Essay
2 Citations
4,845 Views
12 Pages
Implementation and Validation of the Roche Light Cycler 480 96-Well Plate Platform as a Real-Time PCR Assay for the Quantitative Detection of Cytomegalovirus (CMV) in Clinical Specimens Using the Luminex MultiCode ASRs System
- Shengwen Calvin Li,
- Kara J. Sparks and
- Leonard S. Sender
Allogenic stem-cell therapies benefit patients in the treatment of multiple diseases; however, the side effects of stem-cell therapies (SCT) derived from the concomitant use of immune suppression agents often include triggering infection diseases. Th...
- Article
18 Citations
5,337 Views
16 Pages
Cholecalciferol Inhibits Cell Growth and Induces Apoptosis in the CaSki Cell Line
- Sachin Bhoora,
- Yuvelia Pather,
- Sumari Marais and
- Rivak Punchoo
Vitamin D has displayed anti-cancer actions in numerous in vitro studies. Here, we investigated the anti-cancer actions of cholecalciferol, a vitamin D precursor, on a metastatic cervical cancer cell line, namely, CaSki. Experimental cultures were in...
- Meeting Report
3 Citations
4,880 Views
54 Pages
25th International Symposium on Infections in the Critically Ill Patient
- Antonio Artigas,
- Jean Carlet,
- Ricard Ferrer,
- Michael Niederman and
- Antoni Torres
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- Review
5 Citations
4,820 Views
14 Pages
The Interplay between Vascular Function and Sexual Health in Prostate Cancer: The Potential Benefits of Exercise Training
- Natalie K. Vear,
- Jeff S. Coombes,
- Tom G. Bailey and
- Tina L. Skinner
Prostate cancer and its associated treatments can cause significant and lasting morbidities, such as cardiovascular and sexual dysfunctions. Various interventions have attempted to prevent or mitigate these dysfunctions. This review summarises the av...
- Article
11 Citations
4,902 Views
14 Pages
Persistent Urogenital Schistosomiasis and Its Associated Morbidity in Endemic Communities within Southern Ghana: Suspected Praziquantel Resistance or Reinfection?
- Patience B. Tetteh-Quarcoo,
- Peter O. Forson,
- Seth K. Amponsah,
- John Ahenkorah,
- Japheth A. Opintan,
- Janet E. Y. Ocloo,
- Esther N. Okine,
- Robert Aryee,
- Emmanuel Afutu and
- Abraham K. Anang
- + 1 author
Background: schistosomiasis is a neglected tropical disease caused by helminths of the genus Schistosoma. The disease has a worldwide distribution, with more cases occurring in Africa. Urogenital schistosomiasis caused by S. haematobium with its asso...
- Review
28 Citations
4,398 Views
11 Pages
A Systematic Review of the Extra-Hepatic Manifestations of Hepatitis E Virus Infection
- Prashanth Rawla,
- Jeffrey Pradeep Raj,
- Alan Jose Kannemkuzhiyil,
- John Sukumar Aluru,
- Krishna Chaitanya Thandra and
- Mahesh Gajendran
Hepatitis E virus (HEV) is a non-enveloped, positive-sense, single-stranded RNA icosahedral virus belongs to the genus Orthohepevirus within the Hepeviridae family. HEV infection can be asymptomatic, or it can cause icteric or fulminant hepatitis. Of...
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Med. Sci. - ISSN 2076-3271