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Medical Sciences, Volume 8, Issue 1

2020 March - 18 articles

Cover Story: Breast cancer is the most commonly occurring cancer in women. At the molecular level, breast cancer is a heterogeneous disease characterized by high genomic instability, as evidenced by somatic gene mutations, copy number alterations, and chromosome structural rearrangements. This genomic instability is caused by defects in DNA damage repair, transcription, and DNA replication. Breast cancers are subdivided in subtypes according to their molecular features, such as the activation of hormone receptors (estrogen and progesterone receptors) of HER2 and/or BRCA mutations. While early-stage breast cancer is a curable disease in about 70% of patients, advanced breast cancer is largely incurable. However, molecular studies have contributed to developing new therapeutic approaches targeting HER2, CDK4/6, PI3K. View this paper.
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Articles (18)

  • Review
  • Open Access
172 Citations
16,844 Views
103 Pages

23 March 2020

Breast cancer is the most commonly occurring cancer in women. There were over two-million new cases in world in 2018. It is the second leading cause of death from cancer in western countries. At the molecular level, breast cancer is a heterogeneous d...

  • Feature Paper
  • Article
  • Open Access
7 Citations
4,407 Views
11 Pages

Feasibility of Telephone Follow-Up after Critical Care Discharge

  • Sofia Hodalova,
  • Sarah Moore,
  • Joanne Dowds,
  • Niamh Murphy,
  • Ignacio Martin-Loeches and
  • Julie Broderick

14 March 2020

Background: Critical care has evolved from a primary focus on short-term survival, with greater attention being placed on longer-term health care outcomes. It is not known how best to implement follow-up after critical care discharge. Study aims were...

  • Review
  • Open Access
778 Citations
35,412 Views
12 Pages

Epidemiology of Bladder Cancer

  • Kalyan Saginala,
  • Adam Barsouk,
  • John Sukumar Aluru,
  • Prashanth Rawla,
  • Sandeep Anand Padala and
  • Alexander Barsouk

13 March 2020

Based on the latest GLOBOCAN data, bladder cancer accounts for 3% of global cancer diagnoses and is especially prevalent in the developed world. In the United States, bladder cancer is the sixth most incident neoplasm. A total of 90% of bladder cance...

  • Essay
  • Open Access
2 Citations
4,938 Views
12 Pages

11 March 2020

Allogenic stem-cell therapies benefit patients in the treatment of multiple diseases; however, the side effects of stem-cell therapies (SCT) derived from the concomitant use of immune suppression agents often include triggering infection diseases. Th...

  • Article
  • Open Access
18 Citations
5,431 Views
16 Pages

Cholecalciferol Inhibits Cell Growth and Induces Apoptosis in the CaSki Cell Line

  • Sachin Bhoora,
  • Yuvelia Pather,
  • Sumari Marais and
  • Rivak Punchoo

13 February 2020

Vitamin D has displayed anti-cancer actions in numerous in vitro studies. Here, we investigated the anti-cancer actions of cholecalciferol, a vitamin D precursor, on a metastatic cervical cancer cell line, namely, CaSki. Experimental cultures were in...

  • Review
  • Open Access
5 Citations
5,068 Views
14 Pages

11 February 2020

Prostate cancer and its associated treatments can cause significant and lasting morbidities, such as cardiovascular and sexual dysfunctions. Various interventions have attempted to prevent or mitigate these dysfunctions. This review summarises the av...

  • Article
  • Open Access
11 Citations
5,004 Views
14 Pages

Persistent Urogenital Schistosomiasis and Its Associated Morbidity in Endemic Communities within Southern Ghana: Suspected Praziquantel Resistance or Reinfection?

  • Patience B. Tetteh-Quarcoo,
  • Peter O. Forson,
  • Seth K. Amponsah,
  • John Ahenkorah,
  • Japheth A. Opintan,
  • Janet E. Y. Ocloo,
  • Esther N. Okine,
  • Robert Aryee,
  • Emmanuel Afutu and
  • Patrick F. Ayeh-Kumi
  • + 1 author

10 February 2020

Background: schistosomiasis is a neglected tropical disease caused by helminths of the genus Schistosoma. The disease has a worldwide distribution, with more cases occurring in Africa. Urogenital schistosomiasis caused by S. haematobium with its asso...

  • Review
  • Open Access
29 Citations
4,567 Views
11 Pages

A Systematic Review of the Extra-Hepatic Manifestations of Hepatitis E Virus Infection

  • Prashanth Rawla,
  • Jeffrey Pradeep Raj,
  • Alan Jose Kannemkuzhiyil,
  • John Sukumar Aluru,
  • Krishna Chaitanya Thandra and
  • Mahesh Gajendran

4 February 2020

Hepatitis E virus (HEV) is a non-enveloped, positive-sense, single-stranded RNA icosahedral virus belongs to the genus Orthohepevirus within the Hepeviridae family. HEV infection can be asymptomatic, or it can cause icteric or fulminant hepatitis. Of...

  • Article
  • Open Access
29 Citations
5,873 Views
13 Pages

Exercise-Induced Oxygen Desaturation during the 6-Minute Walk Test

  • Raghav Gupta,
  • Gregg L. Ruppel and
  • Joseph Roland D. Espiritu

31 January 2020

The 6-minute walk test (6MWT) is not intended to document oxygen (O2) desaturation during exertion but is often used for this purpose. Because of this, it only has modest reproducibility in determining the need for ambulatory O2 therapy in patients w...

  • Review
  • Open Access
30 Citations
8,896 Views
12 Pages

The Potential Role of Astrocytes in Parkinson’s Disease (PD)

  • Hiluf Hindeya Gebreyesus and
  • Teklu Gebrehiwot Gebremichael

27 January 2020

Astrocytes are multi-functional cells, now recognized as critical participants in many brain functions. They play a critical physiological role in the clearance of neurotransmitters, such as glutamate and gamma-aminobutyric acid (GABA), and in the re...

  • Article
  • Open Access
3 Citations
4,778 Views
10 Pages

25 January 2020

(1) Background: Present methods for drug susceptibility tests (DST) rely on culture methods that are sophisticated and relatively faster, or a slow and cheaper option. These methods frustrate disease control; therefore, there is a need for methods th...

  • Article
  • Open Access
13 Citations
7,048 Views
14 Pages

Defining Community-Acquired Pneumonia as a Public Health Threat: Arguments in Favor from Spanish Investigators

  • Catia Cillóniz,
  • Rosario Menéndez,
  • Carolina García-Vidal,
  • Juan Manuel Péricas and
  • Antoni Torres

25 January 2020

Despite advances in its prevention, pneumonia remains associated with high morbidity, mortality, and health costs worldwide. Studies carried out in the last decade have indicated that more patients with community-acquired pneumonia (CAP) now require...

  • Article
  • Open Access
20 Citations
6,759 Views
11 Pages

The Presence of Immature GV− Stage Oocytes during IVF/ICSI Is a Marker of Poor Oocyte Quality: A Pilot Study

  • Pia Astbury,
  • Goutham N. Subramanian,
  • Jessica Greaney,
  • Chris Roling,
  • Jacqui Irving and
  • Hayden A. Homer

16 January 2020

Here we investigate whether the presence of germinal vesicle-stage oocytes (GV− oocytes) reflects poor oocyte developmental competence (or quality). This was a prospective, non-randomised, cohort pilot-study involving 60 patients undergoing in...

  • Editorial
  • Open Access
3 Citations
3,063 Views
3 Pages

6 January 2020

Metabolic syndrome (MetS), also termed insulin resistance syndrome, has been defined by World Health Organization (WHO) as a multi-factorial disorder characterized by a wide array of cardiometabolic risk factors that increase the risk of coronary hea...

  • Article
  • Open Access
7 Citations
5,264 Views
20 Pages

29 December 2019

As the leading cause of cancer death worldwide, lung cancer (LC) has seriously affected human health and longevity. Chinese medicine is a complex system guided by traditional Chinese medicine theories (TCM). Nowadays, the clinical application of TCM...

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Med. Sci. - ISSN 2076-3271