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Medical Sciences, Volume 10, Issue 4

2022 December - 17 articles

Cover Story: Vasopressors and inotropes (V/I) are widely used in the treatment of cardiogenic shock (CS). Despite improvements in hemodynamic variables and end-organ perfusion, these agents have been associated with an increase in mortality, potentially due to the increased risk of tachyarrhythmias—which may be mitigated by beta-blockers (BBs). Based on a retrospective chart review of 227 patients who received a V/I for CS, concurrent BB usage with a V/I was not associated with a reduction in in-hospital mortality based on the multivariable logistic regression analysis. The present study sheds light on the importance of large, carefully designed clinical studies to optimize inpatient medical therapy, particularly evaluating the combination of V/I and BB, in this high-risk patient population. View this paper
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Articles (17)

  • Article
  • Open Access
3 Citations
2,264 Views
9 Pages

T-Peak to T-End Interval for Prediction of Positive Response to Ajmaline Challenge Test in Suspected Brugada Syndrome Patients

  • Mananchaya Thapanasuta,
  • Ronpichai Chokesuwattanaskul,
  • Pattranee Leelapatana,
  • Voravut Rungpradubvong and
  • Somchai Prechawat

19 December 2022

Background: Brugada syndrome (BrS) is diagnosed in patients with ST-segment elevation with coved-type morphology in the right precordial leads, occurring spontaneously or after provocative drugs. Due to electrocardiographic (ECG) inconsistency, provo...

  • Review
  • Open Access
12 Citations
4,507 Views
21 Pages

Antioxidant Defense and Pseudoexfoliation Syndrome: An Updated Review

  • Stylianos Mastronikolis,
  • Konstantinos Kagkelaris,
  • Marina Pagkalou,
  • Evangelos Tsiambas,
  • Panagiotis Plotas and
  • Constantinos D. Georgakopoulos

14 December 2022

Oxidative stress (OS) affects the anterior ocular tissues, rendering them susceptible to several eye diseases. On the other hand, protection of the eye from harmful factors is achieved by unique defense mechanisms, including enzymatic and non-enzymat...

  • Article
  • Open Access
15 Citations
4,476 Views
15 Pages

Population Risk Factors for Severe Disease and Mortality in COVID-19 in the United States during the Pre-Vaccine Era: A Retrospective Cohort Study of National Inpatient Sample

  • Kavin Raj,
  • Karthik Yeruva,
  • Keerthana Jyotheeswara Pillai,
  • Preetham Kumar,
  • Ankit Agrawal,
  • Sanya Chandna,
  • Akhilesh Khuttan,
  • Shalini Tripathi,
  • Ramya Akella and
  • Ramdas G Pai
  • + 8 authors

4 December 2022

Background-Previous studies on coronavirus disease 2019 (COVID-19) were limited to specific geographical locations and small sample sizes. Therefore, we used the National Inpatient Sample (NIS) 2020 database to determine the risk factors for severe o...

  • Article
  • Open Access
2,830 Views
11 Pages

21 November 2022

Background: Cancer treatments have gradually evolved into targeted molecular therapies characterized by a unique mechanism of action instead of non-specific cytotoxic chemotherapies. However, they have unique safety concerns. For instance, endocrinop...

  • Article
  • Open Access
6 Citations
5,320 Views
7 Pages

The Usage of Concomitant Beta-Blockers with Vasopressors and Inotropes in Cardiogenic Shock

  • Rachel Ryu,
  • Christopher Hauschild,
  • Khaled Bahjri and
  • Huyentran Tran

17 November 2022

Vasopressors and inotropes (Vs/Is) are widely used in the treatment of cardiogenic shock (CS). Despite improvements in hemodynamic variables and end-organ perfusion, these agents have been associated with an increase in mortality, potentially due to...

  • Article
  • Open Access
1 Citations
2,540 Views
16 Pages

Transient Receptor Potential Vanilloid 1 Signaling Is Independent on Protein Kinase A Phosphorylation of Ankyrin-Rich Membrane Spanning Protein

  • Antonio Pellegrino,
  • Sandra Mükusch,
  • Viola Seitz,
  • Christoph Stein,
  • Friedrich W. Herberg and
  • Harald Seitz

17 November 2022

The sensory ion channel transient receptor potential vanilloid 1 (TRPV1) is mainly expressed in small to medium sized dorsal root ganglion neurons, which are involved in the transfer of acute noxious thermal and chemical stimuli. The Ankyrin-rich mem...

  • Communication
  • Open Access
11 Citations
3,123 Views
14 Pages

28 October 2022

Background: 5-Fluorouracil (5-FU) represents one of the major constituents of chemotherapy combination regimens in colon cancer (CRC) treatments; however, this regimen is linked with severe adverse effects and chemoresistance. Thus, developing more e...

  • Article
  • Open Access
2,195 Views
7 Pages

Mental Health of Nurses Working in a Judicial Psychiatry Hospital during the COVID-19 Pandemic in Italy: An Online Survey

  • Gianluca La Rosa,
  • Maria Grazia Maggio,
  • Antonino Cannavò,
  • Daniele Tripoli,
  • Federico Di Mauro,
  • Carmela Casella,
  • Giuseppe Rao,
  • Alfredo Manuli and
  • Rocco Salvatore Calabrò

24 October 2022

The onset of this new pandemic has highlighted the numerous critical issues at the organizational level, which involve both national healthcare and the judicial system. For this reason, nurses working in prisons may exhibit a poor quality of life, ma...

  • Case Report
  • Open Access
6 Citations
3,859 Views
8 Pages

20 October 2022

Immunosuppression changes both susceptibility to and presentation of infection. Infection with one pathogen can also alter host response to a different, unrelated pathogen. These interactions have been seen across multiple infection domains where bac...

  • Communication
  • Open Access
10 Citations
3,595 Views
8 Pages

Improvement of Gait after Robotic-Assisted Training in Children with Cerebral Palsy: Are We Heading in the Right Direction?

  • Rosaria De Luca,
  • Mirjam Bonanno,
  • Carmela Settimo,
  • Rosalia Muratore and
  • Rocco Salvatore Calabrò

13 October 2022

Cerebral palsy (CP) is a non-progressive congenital neurological disorder that affects different physical and cognitive functions in children. In addition to standard rehabilitation, advanced robotic gait devices are novel tools that are becoming pro...

  • Review
  • Open Access
22 Citations
6,921 Views
23 Pages

10 October 2022

SARS-CoV-2-infected symptomatic patients often suffer from high fever and loss of appetite which are responsible for the deficit of fluids and of protein intake. Many patients admitted to the emergency room are, therefore, hypovolemic and hypoprotein...

  • Review
  • Open Access
1 Citations
3,674 Views
8 Pages

29 September 2022

During the COVID-19 pandemic, percutaneous tracheostomy proved to be an effective option in the management of patients with prolonged periods of intubation. In fact, among other things, it allowed early discharge from ICUs and contributed to reducing...

  • Article
  • Open Access
5 Citations
3,988 Views
7 Pages

A Pilot Study of Electrocardiographic Features in Patients with Obesity from a Tertiary Care Centre in Southern India (Electron)

  • Aditya John Binu,
  • Sirish Chandra Srinath,
  • Kripa Elizabeth Cherian,
  • John Roshan Jacob,
  • Thomas V. Paul and
  • Nitin Kapoor

28 September 2022

Background: Obesity is associated with increased all-cause mortality and cardiovascular disease (CVD). An electrocardiogram (ECG) may be used to screen for subtle signs of CVD or altered cardiac morphology in the obese. Methodology: This observationa...

  • Article
  • Open Access
8 Citations
4,195 Views
12 Pages

Training-Induced Muscle Fatigue with a Powered Lower-Limb Exoskeleton: A Preliminary Study on Healthy Subjects

  • Renato Baptista,
  • Francesco Salvaggio,
  • Caterina Cavallo,
  • Serena Pizzocaro,
  • Svonko Galasso,
  • Micaela Schmid and
  • Alessandro Marco De Nunzio

26 September 2022

Powered lower-limb exoskeletons represent a promising technology for helping the upright stance and gait of people with lower-body paralysis or severe paresis from spinal cord injury. The powered lower-limb exoskeleton assistance can reduce the devel...

  • Brief Report
  • Open Access
2 Citations
2,657 Views
8 Pages

Easy Intra-Operative Localization of Pulmonary Nodules during Uniportal Video-Assisted Thoracoscopy: Experience with Hydrogel Plugs at Our Institution

  • Filippo Longo,
  • Rosario Francesco Grasso,
  • Giovanni Tacchi,
  • Luca Frasca,
  • Eliodoro Faiella and
  • Pierfilippo Crucitti

23 September 2022

Background: The diffusion of lung cancer screening programs has increased the detection of both solid and ground-glass opacity (GGO) sub-centimetric lesions, leading to the necessity for histological diagnoses. A percutaneous CT-guided biopsy may be...

  • Review
  • Open Access
10 Citations
13,233 Views
16 Pages

Time to Load Up–Resistance Training Can Improve the Health of Women with Polycystic Ovary Syndrome (PCOS): A Scoping Review

  • Chris Kite,
  • Elizabeth Parkes,
  • Suzan R. Taylor,
  • Robert W. Davies,
  • Lukasz Lagojda,
  • James E. Brown,
  • David R. Broom,
  • Ioannis Kyrou and
  • Harpal S. Randeva

22 September 2022

Background: Guidelines for the management of polycystic ovary syndrome (PCOS) focus on lifestyle changes, incorporating exercise. Whilst evidence suggests that aerobic exercise may be beneficial, less is known about the effectiveness of resistance tr...

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Med. Sci. - ISSN 2076-3271