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Medical Sciences, Volume 10, Issue 3

September 2022 - 19 articles

Cover Story: Polyamines, spermidine, and spermine are positively charged aliphatic cations. They are critical in the regulation of molecular interactions and biological functions. Because of their important physiological role, their cellular levels are tightly regulated through their import, export, de novo synthesis, and catabolism. Enzymes and enzymatic cascades involved in polyamine metabolism are well characterized. Disturbances in the activity of enzymes involved in polyamine metabolism and the consequent changes in polyamine levels and products of their metabolism lead to cell injury and tissue damage. The preponderance of scientific evidence substantiates the critical role of polyamines and their metabolism in the maintenance of physiological normalcy and the disturbances in polyamine levels and catabolism in the mediation of tissue injury. View this paper
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Articles (19)

  • Article
  • Open Access
4 Citations
3,463 Views
9 Pages

Clinicopathological Characteristics and Overall 5-Year Survival of Colorectal Cancer: A Retrospective Study

  • Rahaf Almuhanna,
  • Fatma Al-Thoubaity,
  • Khadijah Almalki,
  • Nada Algarni,
  • Renad Hamad and
  • Toleen Makhtoum

9 August 2022

Colorectal cancer (CRC) is the third leading cause of cancer-related death. We aimed to investigate the clinicopathological characteristics and 5-year survival in CRC. This retrospective study reviewed King Abdulaziz University Hospital records from...

  • Article
  • Open Access
7 Citations
2,751 Views
7 Pages

8 August 2022

In health professions education, team-based learning (TBL) has been used to help learners develop clinical reasoning and decision-making skills. The COVID-19 pandemic has challenged institutions to move curriculum delivery from largely in-person to o...

  • Review
  • Open Access
62 Citations
9,676 Views
32 Pages

Nitrogen is an essential element required for bacterial growth. It serves as a building block for the biosynthesis of macromolecules and provides precursors for secondary metabolites. Bacteria have developed the ability to use various nitrogen source...

  • Review
  • Open Access
6 Citations
10,901 Views
12 Pages

Vasovagal reactions are a benign but common outcome of interventional pain management procedures that can negatively impact patient care, including aborted procedures and fear of future procedures that would otherwise help the patient. Research has b...

  • Review
  • Open Access
43 Citations
8,405 Views
18 Pages

The polyamines spermidine and spermine are positively charged aliphatic molecules. They are critical in the regulation of nucleic acid and protein structures, protein synthesis, protein and nucleic acid interactions, oxidative balance, and cell proli...

  • Article
  • Open Access
14 Citations
5,851 Views
10 Pages

The Use of Palmitoylethanolamide in the Treatment of Long COVID: A Real-Life Retrospective Cohort Study

  • Loredana Raciti,
  • Rosaria De Luca,
  • Gianfranco Raciti,
  • Francesca Antonia Arcadi and
  • Rocco Salvatore Calabrò

COVID-19 can cause symptoms that last weeks or months after the infection has gone, with a significant impairment of quality of life. Palmitoylethanolamide (PEA) is a naturally occurring lipid mediator that has an entourage effect on the endocannabin...

  • Article
  • Open Access
17 Citations
3,942 Views
8 Pages

Hyperbilirubinemia and Hyponatremia as Predictors of Complicated Appendicitis

  • Abdullah Shuaib,
  • Nour Alhamdan,
  • Husain Arian,
  • Mohamed Alaa Sallam and
  • Ali Shuaib

Several studies have reported elevated serum bilirubin or reduced serum sodium levels in patients with complicated appendicitis (CA). This study examined the efficacy of hyperbilirubinemia, hyponatremia, and both combined in the preoperative diagnosi...

  • Brief Report
  • Open Access
4 Citations
2,593 Views
8 Pages

SOCIUS Mentoring—A Novel Course to Encourage Students for a Career as Surgical Oncologists

  • Rüdiger Klapdor,
  • Moritz Kleine,
  • Tobias Schilling,
  • Stephan Huusmann,
  • Anja Philippeit,
  • Jill Philippeit,
  • Kai Timrott,
  • Marcus Kruppa,
  • Peter Hillemanns and
  • Florian Imkamp

Surgical disciplines are affected by an increasing shortage of young doctors. Studies show that formerly interested students decide against a career in surgical disciplines at the end of their studies or during practical year. Measures to counteract...

  • Article
  • Open Access
6 Citations
3,986 Views
9 Pages

Predictors of Invasiveness in Adenocarcinoma of Lung with Lepidic Growth Pattern

  • Timothy J. Young,
  • Ramin Salehi-Rad,
  • Reza Ronaghi,
  • Jane Yanagawa,
  • Puja Shahrouki,
  • Bianca E. Villegas,
  • Brian Cone,
  • Gregory A. Fishbein,
  • William D. Wallace and
  • Fereidoun Abtin
  • + 1 author

Lung adenocarcinoma with lepidic growth pattern (LPA) is characterized by tumor cell proliferation along intact alveolar walls, and further classified as adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA) and invasive lepidic predo...

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Med. Sci. - ISSN 2076-3271