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Microorganisms 2019, 7(2), 48;

Extracellular Vesicles in Epstein-Barr Virus’ Life Cycle and Pathogenesis

Tulane University Health Sciences Center and Tulane Cancer Center, New Orleans, LA 70112, USA
Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido 060-8638, Japan
Department of Medicine, Peptide Research Laboratories, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
Author to whom correspondence should be addressed.
Received: 28 January 2019 / Revised: 8 February 2019 / Accepted: 9 February 2019 / Published: 11 February 2019
(This article belongs to the Special Issue Recent Advances in Understanding Epstein-Barr Virus)
Full-Text   |   PDF [279 KB, uploaded 22 February 2019]


Extracellular vesicles (EVs), including exosomes and microvesicles, are evolutionarily conserved phospholidpid membrane-bound entities secreted from most eukaryotic cell types. They carry bioactive cargos such as protein and nucleic acids derived from their cells of origin. Over the past 10 years, they have been attracting increased attention in many fields of life science, representing a new route for intercellular communication. In this review article, we will discuss the current knowledge of both normal and virally modified EVs in the regulation of Epstein-Barr virus (EBV)’s life cycle and its associated pathogenesis. View Full-Text
Keywords: Epstein-Barr virus; EBV; extracellular vesicle; EV; exosome Epstein-Barr virus; EBV; extracellular vesicle; EV; exosome
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Zhao, M.; Nanbo, A.; Sun, L.; Lin, Z. Extracellular Vesicles in Epstein-Barr Virus’ Life Cycle and Pathogenesis. Microorganisms 2019, 7, 48.

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