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Pathogens
Volume 13
Issue 2
10.3390/pathogens13020133
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Brief Report

An Assessment of West Nile and Usutu Viruses’ Seroprevalence in Hospitalized Patients: A Preliminary Study on Flavivirus Exposure in Eastern Romania

by
Luciana Alexandra Crivei
1,*,
Andrei Vata
2,3,
Danut Teodor
2,
Daniela Porea
1,4,
Andreea Paula Cozma
5,
Adriana Anita
1,5,
Luanda Elena Oslobanu
1,5,
Serban Morosan
5,6 and
Gheorghe Savuta
1,5
1
Regional Center of Advanced Research for Emerging Diseases, Zoonoses and Food Safety, Department of Public Health, Faculty of Veterinary Medicine, Iași University of Life Sciences, 700490 Iași, Romania
2
“Sf. Parascheva” Infectious Diseases Hospital of Iasi, 700490 Iasi, Romania
3
Department of Infectious Diseases, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, 700490 Iași, Romania
4
Laboratories and Research Stations Department, Danube Delta National Institute for Research and Development, 820112 Tulcea, Romania
5
Faculty of Veterinary Medicine, Iași University of Life Sciences, 700490 Iași, Romania
6
Faculté de Médecine, Sorbonne Université, UMS 28, Inserm, 75013 Paris, France
*
Author to whom correspondence should be addressed.
Pathogens 2024, 13(2), 133; https://doi.org/10.3390/pathogens13020133
Submission received: 3 December 2023 / Revised: 12 January 2024 / Accepted: 26 January 2024 / Published: 31 January 2024
Versions Notes

Abstract

WNV and USUV are closely related epornitic flaviviruses transmitted by Culex mosquitoes which can cause febrile and neurodegenerative disease in humans. The impact of both viruses on public health has increased in the recent decades. Aim: The aim of the study was to evaluate the seroprevalence of WNV and USUV in hospitalized patients from eastern Romania who did not show symptoms corresponding to the case definition. Methods: Human blood samples from the hospitalized patients were collected in 2015 and from April to September 2019 in Iasi County, Romania. The samples were screened by ELISA for anti-WNV IgG, IgM, and anti-USUV IgG antibodies. Results: A cumulative seroprevalence of 3.4% was recorded for anti-WNV IgG antibodies and 9.1% for anti-WNV IgM. No sample was positive for anti-USUV antibodies. Conclusion: The cumulative seroprevalence observed provides support for the consideration of WNV as being endemic in the east of Romania. The absence of anti-USUV antibodies may be related to cross-reactivity and cohort size, thus, USUV should be considered in clinical practice and become an objective for active surveillance in Romania.
Keywords: arbovirus; West Nile virus; Usutu virus; Romania; mosquito-borne diseases; seroprevalence; public health arbovirus; West Nile virus; Usutu virus; Romania; mosquito-borne diseases; seroprevalence; public health

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MDPI and ACS Style

Crivei, L.A.; Vata, A.; Teodor, D.; Porea, D.; Cozma, A.P.; Anita, A.; Oslobanu, L.E.; Morosan, S.; Savuta, G. An Assessment of West Nile and Usutu Viruses’ Seroprevalence in Hospitalized Patients: A Preliminary Study on Flavivirus Exposure in Eastern Romania. Pathogens 2024, 13, 133. https://doi.org/10.3390/pathogens13020133

AMA Style

Crivei LA, Vata A, Teodor D, Porea D, Cozma AP, Anita A, Oslobanu LE, Morosan S, Savuta G. An Assessment of West Nile and Usutu Viruses’ Seroprevalence in Hospitalized Patients: A Preliminary Study on Flavivirus Exposure in Eastern Romania. Pathogens. 2024; 13(2):133. https://doi.org/10.3390/pathogens13020133

Chicago/Turabian Style

Crivei, Luciana Alexandra, Andrei Vata, Danut Teodor, Daniela Porea, Andreea Paula Cozma, Adriana Anita, Luanda Elena Oslobanu, Serban Morosan, and Gheorghe Savuta. 2024. "An Assessment of West Nile and Usutu Viruses’ Seroprevalence in Hospitalized Patients: A Preliminary Study on Flavivirus Exposure in Eastern Romania" Pathogens 13, no. 2: 133. https://doi.org/10.3390/pathogens13020133

APA Style

Crivei, L. A., Vata, A., Teodor, D., Porea, D., Cozma, A. P., Anita, A., Oslobanu, L. E., Morosan, S., & Savuta, G. (2024). An Assessment of West Nile and Usutu Viruses’ Seroprevalence in Hospitalized Patients: A Preliminary Study on Flavivirus Exposure in Eastern Romania. Pathogens, 13(2), 133. https://doi.org/10.3390/pathogens13020133

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