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Article

Preparation and Preliminary Evaluation of Silver-Modified Anodic Alumina for Biomedical Applications

by
Denitsa Kiradzhiyska
1,*,
Nikolina Milcheva
1,*,
Rositsa Mancheva
1,
Tsvetelina Batsalova
2,
Balik Dzhambazov
2 and
Nikolay Zahariev
3,4
1
Department of Chemical Sciences, Faculty of Pharmacy, Medical University of Plovdiv, 15A Vassil Aprilov blvd., 4000 Plovdiv, Bulgaria
2
Department of Developmental Biology, Plovdiv University “Paisii Hilendarski”, 24 Tsar Assen Str., 4000 Plovdiv, Bulgaria
3
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Medical University of Plovdiv, 15A Vassil Aprilov blvd., 4000 Plovdiv, Bulgaria
4
Research Institute, Medical University of Plovdiv, 15A Vassil Aprilov blvd., 4000 Plovdiv, Bulgaria
*
Authors to whom correspondence should be addressed.
Metals 2022, 12(1), 51; https://doi.org/10.3390/met12010051
Submission received: 26 November 2021 / Revised: 23 December 2021 / Accepted: 24 December 2021 / Published: 27 December 2021
(This article belongs to the Special Issue Advances in Biomedical Metallic Materials)
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Abstract

The present study reports a specific method for preparation of silver-modified anodic alumina substrates intended for biomaterial applications. Al2O3 coatings were obtained by anodization of technically pure aluminum alloy in sulfuric acid electrolyte. Silver deposition into the pores of the anodic structures was carried out employing in situ thermal reduction for different time periods. The obtained coatings were characterized using scanning electron microscopy (SEM), potentiodynamic scanning after 168 h in 3.5% NaCl solution and bioassays with human fibroblast and NIH/3T3 cell lines. The modified alumina substrates demonstrated better biocompatibility compared to the control anodic Al2O3 pads indicated by increased percent cell survival following in vitro culture with human and mouse fibroblasts. The Ag-deposition time did not affect considerably the biocompatibility of the investigated anodic layers. SEM analyses indicated that mouse NIH/3T3 cells and human fibroblasts adhere to the silver-coated alumina substrates retaining normal morphology and ability to form cell monolayer. Therefore, the present studies demonstrate that silver coating of anodic alumina substrates improves their biocompatibility and their eventual biomedical application.
Keywords: Ag/AAO substrates; biocompatibility; fibroblasts; scanning electron microscopy Ag/AAO substrates; biocompatibility; fibroblasts; scanning electron microscopy

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MDPI and ACS Style

Kiradzhiyska, D.; Milcheva, N.; Mancheva, R.; Batsalova, T.; Dzhambazov, B.; Zahariev, N. Preparation and Preliminary Evaluation of Silver-Modified Anodic Alumina for Biomedical Applications. Metals 2022, 12, 51. https://doi.org/10.3390/met12010051

AMA Style

Kiradzhiyska D, Milcheva N, Mancheva R, Batsalova T, Dzhambazov B, Zahariev N. Preparation and Preliminary Evaluation of Silver-Modified Anodic Alumina for Biomedical Applications. Metals. 2022; 12(1):51. https://doi.org/10.3390/met12010051

Chicago/Turabian Style

Kiradzhiyska, Denitsa, Nikolina Milcheva, Rositsa Mancheva, Tsvetelina Batsalova, Balik Dzhambazov, and Nikolay Zahariev. 2022. "Preparation and Preliminary Evaluation of Silver-Modified Anodic Alumina for Biomedical Applications" Metals 12, no. 1: 51. https://doi.org/10.3390/met12010051

APA Style

Kiradzhiyska, D., Milcheva, N., Mancheva, R., Batsalova, T., Dzhambazov, B., & Zahariev, N. (2022). Preparation and Preliminary Evaluation of Silver-Modified Anodic Alumina for Biomedical Applications. Metals, 12(1), 51. https://doi.org/10.3390/met12010051

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