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Epigenomes, Volume 8, Issue 3

September 2024 - 13 articles

Cover Story: Intrinsically disordered regions (IDRs) are known to cause the oligomerization and accumulation of many proteins. In addition, plants utilize a novel mechanism harnessing the oligomerization capacity of α-Crystalline Domain (ACD)-containing proteins to accumulate the MBD5/6-silencing complex at DNA methylation sites within nuclear chromocenters. The work by Boone et al. shows that the addition of human or plant IDRs led to even more accumulation of MBD5/6 complexes at chromocenters. Furthermore, the removal of ACD proteins only partially reduced this accumulation phenotype. IDR- and ACD-mediated mechanisms can thus act combinatorially to induce high levels of protein multimerization and concentration in nuclear foci. View this paper

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Review

15 Citations

4,790 Views

17 Pages

Oncogenic Roles of UHRF1 in Cancer

Ahhyun Kim and
Claudia A. Benavente

Epigenomes2024, 8(3), 26;https://doi.org/10.3390/epigenomes8030026

1 July 2024

Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is an essential protein involved in the maintenance of repressive epigenetic marks, ensuring epigenetic stability and fidelity. As an epigenetic regulator, UHRF1 comprises several functional d...

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Review

2 Citations

3,483 Views

18 Pages

Epigenetic Regulation of Mammalian Cardiomyocyte Development

Isaiah K. Mensah and
Humaira Gowher

Epigenomes2024, 8(3), 25;https://doi.org/10.3390/epigenomes8030025

29 June 2024

The heart is the first organ formed during mammalian development and functions to distribute nutrients and oxygen to other parts of the developing embryo. Cardiomyocytes are the major cell types of the heart and provide both structural support and co...

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Article

2,726 Views

15 Pages

DNA Hypomethylation Underlies Epigenetic Swapping between AGO1 and AGO1-V2 Isoforms in Tumors

Jean S. Fain,
Camille Wangermez,
Axelle Loriot,
Claudia Denoue and
Charles De Smet

Epigenomes2024, 8(3), 24;https://doi.org/10.3390/epigenomes8030024

22 June 2024

Human tumors progress in part by accumulating epigenetic alterations, which include gains and losses of DNA methylation in different parts of the cancer cell genome. Recent work has revealed a link between these two opposite alterations by showing th...

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