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Epigenomes, Volume 7, Issue 2

June 2023 - 3 articles

Cover Story: Graft-derived cell-free DNA (gdcfDNA) analysis has shown promise as a non-invasive tool for monitoring organ health following solid organ transplantation. In this study, we directly compared two methods for detecting gdcfDNA in clinical samples from patients post-liver transplantation; one based on graft-specific cell-free DNA methylation patterns, and another technique utilising donor and recipient genotyping. Qualitative trends in gdcfDNA levels for each patient were concordant between the two assays. Whilst the two assays performed comparably, gdcfDNA monitoring based on graft-specific DNA methylation patterns offers major practical advantages over donor-recipient genotyping, and hence holds greater potential to translate this emerging technology into clinical practice. View this paper

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Article

5 Citations

3,292 Views

15 Pages

Graft-Derived Cell-Free DNA Quantification following Liver Transplantation Using Tissue-Specific DNA Methylation and Donor-Specific Genotyping Techniques: An Orthogonal Comparison Study

Daniel R. A. Cox,
Tess McClure,
Fan Zhang,
Boris Ka Leong Wong,
Adam Testro,
Su Kah Goh,
Vijayaragavan Muralidharan and
Alexander Dobrovic

Epigenomes2023, 7(2), 11;https://doi.org/10.3390/epigenomes7020011

9 June 2023

Background: Graft-derived cell-free DNA (gdcfDNA) analysis has shown promise as a non-invasive tool for monitoring organ health following solid organ transplantation. A number of gdcfDNA analysis techniques have been described; however, the majority...

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Review

7 Citations

5,720 Views

19 Pages

Histone Demethylase Modulation: Epigenetic Strategy to Combat Cancer Progression

Rashmi Srivastava,
Rubi Singh,
Shaurya Jauhari,
Niraj Lodhi and
Rakesh Srivastava

Epigenomes2023, 7(2), 10;https://doi.org/10.3390/epigenomes7020010

17 May 2023

Epigenetic modifications are heritable, reversible changes in histones or the DNA that control gene functions, being exogenous to the genomic sequence itself. Human diseases, particularly cancer, are frequently connected to epigenetic dysregulations....

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Review

7 Citations

3,513 Views

25 Pages

Critical Considerations for Investigating MicroRNAs during Tumorigenesis: A Case Study in Conceptual and Contextual Nuances of miR-211-5p in Melanoma

Fatemeh Vand-Rajabpour,
Meghan Savage,
Rachel L. Belote and
Robert L. Judson-Torres

Epigenomes2023, 7(2), 9;https://doi.org/10.3390/epigenomes7020009

26 April 2023

MicroRNAs are non-coding RNAs fundamental to metazoan development and disease. Although the aberrant regulation of microRNAs during mammalian tumorigenesis is well established, investigations into the contributions of individual microRNAs are wrought...

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Epigenomes - ISSN 2075-4655

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