Review Reports
by
- Hong Bae Choi 1,†,
- Jung-Soo Pyo 2,† and
- Guhyun Kang 5,*
- et al.
Reviewer 1: Anonymous Reviewer 2: Anonymous
Round 1
Reviewer 1 Report
Gist/Review: A review of this sort where meta-analysis is carried out on CDX2 needs substantial discussions. Although the authors attempt to bring clarity on diagnostics and prognostics of this, I would have personally appreciated had the authors made some decent attempt in analysing the protein interaction networks, pathways from these datasets. This will be a good way.
All the statistical interpretations, plots were deemed to be okay.
Third, . the authors would have overcome the non-finding of histological subtypes, had they used operands ( AND, OR and NOT) in PubMed searches Minor but essential
I think Figure 1 would come in methods NOT results
a phenolyzer map would be a nice addition for this review. Pl draw that figure
In intro, the CRC is abbreviated twice, pl remove the second such instance
The abstract needs to be rewritten for brevity. For example
The study IS aimed....
Line 86. Pl use plural random effect MODELS
Line 212: carcinomas ARE ( replace with is
Author Response
Review 1.
Gist/Review: A review of this sort where meta-analysis is carried out on CDX2 needs substantial discussions. Although the authors attempt to bring clarity on diagnostics and prognostics of this, I would have personally appreciated had the authors made some decent attempt in analysing the protein interaction networks, pathways from these datasets. This will be a good way.
All the statistical interpretations, plots were deemed to be okay.
Third, the authors would have overcome the non-finding of histological subtypes, had they used operands (AND, OR and NOT) in PubMed searches Minor but essential
Response:
We corrected the information for the operands.
I think Figure 1 would come in methods NOT results
Response:
As a recommendation, we corrected the location of Fig.1.
a phenolyzer map would be a nice addition for this review. Pl draw that figure
Response:
In our knowledge, a phenolyzer is a software that implements phenotype-based prioritization of candidate genes for human diseases. However, we analyzed the protein expression of only CDX2.
In intro, the CRC is abbreviated twice, pl remove the second such instance
Response:
As a recommendation, we corrected it.
The abstract needs to be rewritten for brevity. For example
Response:
As a recommendation, we corrected the abstract.
The study IS aimed....
Response:
As a recommendation, we corrected the sentence.
Line 86. Pl use plural random effect MODELS
Response:
As a recommendation, we replaced.
Line 212: carcinomas ARE ( replace with is
Response:
As a recommendation, we replaced “is” to “are”.
Reviewer 2 Report
It's a well written systematic review to evaluate the diagnostic and prognostic role of the immunohistochemical expression of the single biological marker CDX2 in colorectal cancers. Overall this topic has been extensively studied and there are numerous publications available, however, the authors present a comprehensive overview and meta-analysis that summarizes the available data. Of potential interest to the pathologists, surgical and medical oncologists, molecular biologists interested in CRC biology and prognostification.
Author Response
Review 2.
It's a well written systematic review to evaluate the diagnostic and prognostic role of the immunohistochemical expression of the single biological marker CDX2 in colorectal cancers. Overall this topic has been extensively studied and there are numerous publications available, however, the authors present a comprehensive overview and meta-analysis that summarizes the available data. Of potential interest to the pathologists, surgical and medical oncologists, molecular biologists interested in CRC biology and prognostification.
Response:
Thank you for the careful review.