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Volume 13
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10.3390/life13051182
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Project Report

Neuromorphological Atlas of Human Prenatal Brain Development: White Paper

by
Alexandra Proshchina
*,
Anastasia Kharlamova
,
Yuliya Krivova
,
Olga Godovalova
,
Dmitriy Otlyga
,
Victoria Gulimova
,
Ekaterina Otlyga
,
Olga Junemann
,
Gleb Sonin
and
Sergey Saveliev
Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution “Petrovsky National Research Centre of Surgery”, Tsurupi Street, 3, 117418 Moscow, Russia
*
Author to whom correspondence should be addressed.
Life 2023, 13(5), 1182; https://doi.org/10.3390/life13051182
Submission received: 29 March 2023 / Revised: 6 May 2023 / Accepted: 11 May 2023 / Published: 13 May 2023
(This article belongs to the Special Issue New Advances in Neuroimaging and Brain Functions)
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Abstract

Recent morphological data on human brain development are quite fragmentary. However, they are highly requested for a number of medical practices, educational programs, and fundamental research in the fields of embryology, cytology and histology, neurology, physiology, path anatomy, neonatology, and others. This paper provides the initial information on the new online Human Prenatal Brain Development Atlas (HBDA). The Atlas will start with forebrain annotated hemisphere maps, based on human fetal brain serial sections at the different stages of prenatal ontogenesis. Spatiotemporal changes in the regional-specific immunophenotype profiles will also be demonstrated on virtual serial sections. The HBDA can serve as a reference database for the neurological research, which provides opportunity to compare the data obtained by noninvasive techniques, such as neurosonography, X-ray computed tomography and magnetic resonance imaging, functional magnetic resonance imaging, 3D high-resolution phase-contrast computed tomography visualization techniques, as well as spatial transcriptomics data. It could also become a database for the qualitative and quantitative analysis of individual variability in the human brain. Systemized data on the mechanisms and pathways of prenatal human glio- and neurogenesis could also contribute to the search for new therapy methods for a large spectrum of neurological pathologies, including neurodegenerative and cancer diseases. The preliminary data are now accessible on the special HBDA website.
Keywords: human brain atlas; human prenatal development; fetal brain; proteome; forebrain; neurogenesis human brain atlas; human prenatal development; fetal brain; proteome; forebrain; neurogenesis

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MDPI and ACS Style

Proshchina, A.; Kharlamova, A.; Krivova, Y.; Godovalova, O.; Otlyga, D.; Gulimova, V.; Otlyga, E.; Junemann, O.; Sonin, G.; Saveliev, S. Neuromorphological Atlas of Human Prenatal Brain Development: White Paper. Life 2023, 13, 1182. https://doi.org/10.3390/life13051182

AMA Style

Proshchina A, Kharlamova A, Krivova Y, Godovalova O, Otlyga D, Gulimova V, Otlyga E, Junemann O, Sonin G, Saveliev S. Neuromorphological Atlas of Human Prenatal Brain Development: White Paper. Life. 2023; 13(5):1182. https://doi.org/10.3390/life13051182

Chicago/Turabian Style

Proshchina, Alexandra, Anastasia Kharlamova, Yuliya Krivova, Olga Godovalova, Dmitriy Otlyga, Victoria Gulimova, Ekaterina Otlyga, Olga Junemann, Gleb Sonin, and Sergey Saveliev. 2023. "Neuromorphological Atlas of Human Prenatal Brain Development: White Paper" Life 13, no. 5: 1182. https://doi.org/10.3390/life13051182

APA Style

Proshchina, A., Kharlamova, A., Krivova, Y., Godovalova, O., Otlyga, D., Gulimova, V., Otlyga, E., Junemann, O., Sonin, G., & Saveliev, S. (2023). Neuromorphological Atlas of Human Prenatal Brain Development: White Paper. Life, 13(5), 1182. https://doi.org/10.3390/life13051182

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