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10.3390/life13051175
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Article

Association between Clinical and Histopathological Findings in Intestinal Neuronal Dysplasia Type B: An Advance towards Its Definition as a Disease

by
Anderson Cesar Gonçalves
,
Isabelle Stefan de Faria Oliveira
,
Pedro Tadao Hamamoto Filho
,
Erika Veruska Paiva Ortolan
,
Simone Antunes Terra
,
Maria Aparecida Marchesan Rodrigues
and
Pedro Luiz Toledo de Arruda Lourenção
*
Botucatu Medical School, São Paulo State University (UNESP), Botucatu 18618-687, Brazil
*
Author to whom correspondence should be addressed.
Life 2023, 13(5), 1175; https://doi.org/10.3390/life13051175
Submission received: 15 March 2023 / Revised: 30 April 2023 / Accepted: 9 May 2023 / Published: 12 May 2023
(This article belongs to the Special Issue Trends and Outlooks in Neurogastroenterology)
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Abstract

Introduction: Intestinal neuronal dysplasia type B (IND-B) is a controversial entity that affects the submucosal nerve plexus of the distal intestine. The lack of definition of the causal relationship between histological findings and clinical symptoms has been identified as the primary point to be elucidated in the scientific investigation related to IND-B, which is essential for it to be considered a disease. Objective: To investigate the relationship between histopathological findings and symptoms in a series of patients with IND-B. Methods: Twenty-seven patients with histopathological diagnosis of IND-B, according to the Frankfurt Consensus (1990), who underwent surgical treatment through colorectal resections were included. Data from medical records regarding the clinical picture of the patients at the time of diagnosis, including the intestinal symptom index (ISI) and a detailed histopathological analysis of the rectal specimens, were retrieved. Exploratory factor analysis was performed, applying the principal components method for clusters with Varimax rotation. Results: Two factors were determined: the first, determined by histopathological and clinical variables, and the second, composed of the main symptoms presented in patients with IND-B, including ISI. Factorial rotation showed the association between the two factors and, through a graph, demonstrated the proximity between ISI values and histopathological alterations. Conclusion: There was evidence of an association between the clinical features presented by patients with IND-B and the histopathological findings of the rectal samples. These results support the understanding of IND-B as a disease.
Keywords: intestinal neuronal dysplasia type B; constipation; children intestinal neuronal dysplasia type B; constipation; children

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MDPI and ACS Style

Gonçalves, A.C.; de Faria Oliveira, I.S.; Hamamoto Filho, P.T.; Ortolan, E.V.P.; Terra, S.A.; Rodrigues, M.A.M.; de Arruda Lourenção, P.L.T. Association between Clinical and Histopathological Findings in Intestinal Neuronal Dysplasia Type B: An Advance towards Its Definition as a Disease. Life 2023, 13, 1175. https://doi.org/10.3390/life13051175

AMA Style

Gonçalves AC, de Faria Oliveira IS, Hamamoto Filho PT, Ortolan EVP, Terra SA, Rodrigues MAM, de Arruda Lourenção PLT. Association between Clinical and Histopathological Findings in Intestinal Neuronal Dysplasia Type B: An Advance towards Its Definition as a Disease. Life. 2023; 13(5):1175. https://doi.org/10.3390/life13051175

Chicago/Turabian Style

Gonçalves, Anderson Cesar, Isabelle Stefan de Faria Oliveira, Pedro Tadao Hamamoto Filho, Erika Veruska Paiva Ortolan, Simone Antunes Terra, Maria Aparecida Marchesan Rodrigues, and Pedro Luiz Toledo de Arruda Lourenção. 2023. "Association between Clinical and Histopathological Findings in Intestinal Neuronal Dysplasia Type B: An Advance towards Its Definition as a Disease" Life 13, no. 5: 1175. https://doi.org/10.3390/life13051175

APA Style

Gonçalves, A. C., de Faria Oliveira, I. S., Hamamoto Filho, P. T., Ortolan, E. V. P., Terra, S. A., Rodrigues, M. A. M., & de Arruda Lourenção, P. L. T. (2023). Association between Clinical and Histopathological Findings in Intestinal Neuronal Dysplasia Type B: An Advance towards Its Definition as a Disease. Life, 13(5), 1175. https://doi.org/10.3390/life13051175

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