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Symmetry
Volume 13
Issue 10
10.3390/sym13101907
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Review

Analysis of Asymmetric Cell Division Using Human Neuroblastoma Cell Lines as a Model System

by
Hideki Izumi
1,*,
Yasuhiko Kaneko
2 and
Akira Nakagawara
3
1
Laboratory of Molecular Medicine, Saga Medical Center KOSEIKAN, Life Sciences Institute, Saga 840-8571, Japan
2
Saitama Cancer Center, Research Institute for Clinical Oncology, Saitama 362-0806, Japan
3
Saga HIMAT, Tosu 841-0071, Japan
*
Author to whom correspondence should be addressed.
Symmetry 2021, 13(10), 1907; https://doi.org/10.3390/sym13101907
Submission received: 2 August 2021 / Revised: 24 September 2021 / Accepted: 6 October 2021 / Published: 11 October 2021
(This article belongs to the Special Issue Symmetry versus Asymmetry in Cell Biology)
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Abstract

Neuroblastoma is one of the most common childhood solid tumors and develops from neural stem cells that normally comprise the embryonic structure termed the neural crest. Human neuroblastoma cell lines have special properties as they exhibit cell growth and are induced to become mature neurons by drugs such as retinoid. Therefore, we examined asymmetric cell division (ACD) using human neuroblastoma cells as an ACD model, and confirmed that ACD in human cancer cells is evolutionally conserved. Furthermore, we demonstrated that MYCN is involved in cell division fate. We introduce the brief history of ACD study using neuroblastoma cell lines and discuss why human neuroblastoma cells are an ideal model system for clarifying the mechanism of ACD.
Keywords: neuroblastoma; asymmetric cell division; centrosome; MYCN; TRIM32 neuroblastoma; asymmetric cell division; centrosome; MYCN; TRIM32

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MDPI and ACS Style

Izumi, H.; Kaneko, Y.; Nakagawara, A. Analysis of Asymmetric Cell Division Using Human Neuroblastoma Cell Lines as a Model System. Symmetry 2021, 13, 1907. https://doi.org/10.3390/sym13101907

AMA Style

Izumi H, Kaneko Y, Nakagawara A. Analysis of Asymmetric Cell Division Using Human Neuroblastoma Cell Lines as a Model System. Symmetry. 2021; 13(10):1907. https://doi.org/10.3390/sym13101907

Chicago/Turabian Style

Izumi, Hideki, Yasuhiko Kaneko, and Akira Nakagawara. 2021. "Analysis of Asymmetric Cell Division Using Human Neuroblastoma Cell Lines as a Model System" Symmetry 13, no. 10: 1907. https://doi.org/10.3390/sym13101907

APA Style

Izumi, H., Kaneko, Y., & Nakagawara, A. (2021). Analysis of Asymmetric Cell Division Using Human Neuroblastoma Cell Lines as a Model System. Symmetry, 13(10), 1907. https://doi.org/10.3390/sym13101907

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