Next Article in Journal / Special Issue
Telomerase Activation in Hematological Malignancies
Previous Article in Journal
Towards a Better Molecular Diagnosis of FMR1-Related Disorders—A Multiyear Experience from a Reference Lab
Previous Article in Special Issue
Telomeres and Telomerase in Cardiovascular Diseases

The Telomere/Telomerase System in Chronic Inflammatory Diseases. Cause or Effect?

Third Department of Internal Medicine and Diabetes Centre, Saint Panteleimon General Hospital, Nikea-Pireaus 18454, Greece
Department of Clinical Microbiology and Medical Biopathology, Athens Medical School, Aeginition Hospital, Athens 11528, Greece
Department of Nursing, Faculty of Human Movement and Quality of Life Sciences, University of Peloponnese, Sparta 23100, Greece
Author to whom correspondence should be addressed.
Academic Editor: Gabriele Saretzki
Genes 2016, 7(9), 60;
Received: 20 May 2016 / Revised: 26 July 2016 / Accepted: 29 August 2016 / Published: 3 September 2016
(This article belongs to the Special Issue Telomerase Activity in Human Cells)
Telomeres are specialized nucleoprotein structures located at the end of linear chromosomes and telomerase is the enzyme responsible for telomere elongation. Telomerase activity is a key component of many cancer cells responsible for rapid cell division but it has also been found by many laboratories around the world that telomere/telomerase biology is dysfunctional in many other chronic conditions as well. These conditions are characterized by chronic inflammation, a situation mostly overlooked by physicians regarding patient treatment. Among others, these conditions include diabetes, renal failure, chronic obstructive pulmonary disease, etc. Since researchers have in many cases identified the association between telomerase and inflammation but there are still many missing links regarding this correlation, the latest findings about this phenomenon will be discussed by reviewing the literature. Our focus will be describing telomere/telomerase status in chronic diseases under the prism of inflammation, reporting molecular findings where available and proposing possible future approaches. View Full-Text
Keywords: telomerase; telomeres; inflammation; senescence telomerase; telomeres; inflammation; senescence
MDPI and ACS Style

Kordinas, V.; Ioannidis, A.; Chatzipanagiotou, S. The Telomere/Telomerase System in Chronic Inflammatory Diseases. Cause or Effect? Genes 2016, 7, 60.

AMA Style

Kordinas V, Ioannidis A, Chatzipanagiotou S. The Telomere/Telomerase System in Chronic Inflammatory Diseases. Cause or Effect? Genes. 2016; 7(9):60.

Chicago/Turabian Style

Kordinas, Vasileios, Anastasios Ioannidis, and Stylianos Chatzipanagiotou. 2016. "The Telomere/Telomerase System in Chronic Inflammatory Diseases. Cause or Effect?" Genes 7, no. 9: 60.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop