You are currently viewing a new version of our website. To view the old version click .

Genes, Volume 16, Issue 2

February 2025 - 128 articles

Cover Story: The variants rs10517086 and rs1534422 are predictive of type 1 diabetes mellitus (T1DM) development and poor residual β cell function within the first year of diagnosis. However, the mechanism by which risk is conferred is unknown. Using CRISPR/Cas9, we show that both variants significantly reduce glucose-stimulated insulin secretion, increase the production of pro-inflammatory cytokines, and reduce the expression of several β cell markers and transcription factors. However, much of this appeared to be under the control of HNF1A. Analysis of human data revealed an association of rs10517086_A genotype with C-peptide in 153 individuals with T1DM, but not in 417 people with T2DM. Our data suggest that rs1534422 and rs10517086 exert multiple insults on the β cell through excessive upregulation of HNF1A and the induction of pro-inflammatory cytokines. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (128)

  • Article
  • Open Access
2 Citations
3,028 Views
67 Pages

Advances in Understanding the Karyotype Evolution of Tetrapulmonata and Two Other Arachnid Taxa, Ricinulei and Solifugae

  • Jiří Král,
  • Alexandr Sember,
  • Klára Divišová,
  • Tereza Kořínková,
  • Azucena C. Reyes Lerma,
  • Ivalú M. Ávila Herrera,
  • Martin Forman,
  • František Šťáhlavský,
  • Jana Musilová and
  • Sabrina Torres Kalme
  • + 10 authors

8 February 2025

Background/Objectives: Arachnids are a megadiverse arthropod group. The present study investigated the chromosomes of pedipalpid tetrapulmonates (orders Amblypygi, Thelyphonida, Schizomida) and two arachnid orders of uncertain phylogenetic placement,...

  • Article
  • Open Access
2,100 Views
19 Pages

Identification of the SbDUF966 Gene Family in Sorghum and Investigation of It Role in Response to Abiotic Stresses

  • Yu Luo,
  • Minli Wang,
  • Wenda Jiao,
  • Kun Huang,
  • Jiaqi Li,
  • Haiyun Chen,
  • Ruidong Zhang and
  • Xiong Cao

8 February 2025

Background: Sorghum (Sorghum bicolor L.) is an adversity-tolerant crop, but the function of the DUF966 gene family in its growth, development, and stress tolerance is unclear. Methods: The SbDUF966 gene was identified and analyzed using bioinformatic...

  • Review
  • Open Access
2 Citations
5,431 Views
19 Pages

Chlamydia trachomatis: From Urogenital Infections to the Pathway of Infertility

  • Rafaela Rodrigues,
  • Carlos Sousa,
  • Alberto Barros and
  • Nuno Vale

7 February 2025

Chlamydia trachomatis (CT) is a major cause of sexually transmitted infections (STIs) worldwide, with significant implications for reproductive health. The bacterium’s genome contains highly polymorphic regions, influencing both the type and se...

  • Article
  • Open Access
3 Citations
1,337 Views
20 Pages

7 February 2025

Hawthorns (Crataegus L.) are widely distributed and well known for their medicinal properties and health benefits. Nevertheless, the phylogenetic relationships among Crataegus native to China remain unclear. Additionally, no consensus exists on the o...

  • Article
  • Open Access
2,101 Views
16 Pages

7 February 2025

Background/Objectives: Autism spectrum disorder (ASD), defined by social, behavioral, and cognitive anomalies, is also associated with dysregulated appetite. ASD individuals, often described as “picky eaters”, exhibit restricted dietary p...

  • Article
  • Open Access
2 Citations
1,412 Views
13 Pages

Product Speculation from Carotenogenic Gene Cluster of Nonlabens spongiae Genome, and Identification of Myxol and Functional Analysis of Each Gene

  • Keisuke Nakazawa,
  • Daiki Mineo,
  • Takuya Harayama,
  • Susumu Yoshizawa,
  • Shinichi Takaichi and
  • Kenjiro Sugiyama

7 February 2025

Background: Myxol, a monocyclic carotenoid with β- and ψ-end groups, has been identified in only a limited number of bacteria, such as flavobacteria and cyanobacteria. Despite its biological significance, the biosynthetic pathway of myxol is...

  • Article
  • Open Access
3 Citations
1,564 Views
17 Pages

Comparative Chloroplast Genomics and Codon Usage Bias Analysis in Hevea Genus

  • Yang Yang,
  • Xueyang Liu,
  • Lixia He,
  • Zhenhua Li,
  • Boxuan Yuan,
  • Fengyan Fang,
  • Mei Wang,
  • Aifang Li,
  • Cheng Liu and
  • Minmin He
  • + 3 authors

6 February 2025

Objectives: This study investigates the cpDNA sequences from six Hevea species, aiming to explore their genomic characteristics, gene content, and genetic relationships. The objectives include understanding the structure of these genomes, identifying...

  • Article
  • Open Access
1,303 Views
13 Pages

Genome-Wide In Silico Analysis of Leucine-Rich Repeat R-Genes in Perilla citriodora: Classification and Expression Insights

  • Seon-Hwa Bae,
  • Yedomon Ange Bovys Zoclanclounon,
  • Gyu-Hwang Park,
  • Jun-Dae Lee and
  • Tae-Ho Kim

6 February 2025

Background: Resistance (R) genes are crucial for defending Perilla against pathogens like anthracnose, downy mildew, and phytophthora blight. Nucleotide-binding site leucine-rich repeat (NBS-LRR) genes, the largest R-gene family, play a central role...

  • Review
  • Open Access
2 Citations
2,705 Views
15 Pages

The Current State of Breast Cancer Genetics in Populations of African Ancestry

  • Sarah Elisabeth Santos Cupertino,
  • Ana Carolina Aparecida Gonçalves,
  • Claudemira Vieira Gusmão Lopes,
  • Daniela Fiori Gradia and
  • Marcia Holsbach Beltrame

6 February 2025

Breast cancer (BC) constitutes a significant global health burden, particularly among women, with disparities observed across populations. Notably, women of African ancestry often experience BC at earlier ages and in more aggressive forms, with a hig...

  • Article
  • Open Access
1 Citations
1,667 Views
13 Pages

The POLG Variant c.678G>C; p.(Gln226His) Is Associated with Mitochondrial Abnormalities in Fibroblasts Derived from a Patient Compared to a First-Degree Relative

  • Imra Mantey,
  • Felix Langerscheidt,
  • Çağla Çakmak Durmaz,
  • Naomi Baba,
  • Katharina Burghardt,
  • Mert Karakaya and
  • Hans Zempel

5 February 2025

Background: The nuclear-encoded enzyme polymerase gamma (Pol-γ) is crucial in the replication of the mitochondrial genome (mtDNA), which in turn is vital for mitochondria and hence numerous metabolic processes and energy production in eukaryoti...

of 13

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Genes - ISSN 2073-4425