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Genes, Volume 13, Issue 10

October 2022 - 241 articles

Cover Story: Malaria, caused by Plasmodium parasites, is still one of the biggest global health challenges. In recent years, epitranscriptomics is emerging as a new regulatory layer of gene expression. We present evidence of the variety of tRNA and mRNA modifications that are being characterized in Plasmodium spp., and the dynamic changes in their abundance during parasite development and cell fate. We end up outlining that new biological systems, such as the mosquito model, to decipher the unknowns about epigenetic mechanisms in vivo, and novel methodologies, to study the function of RNA modifications, are needed to discover the Achilles heel of the parasite. With this new knowledge, future strategies manipulating the epigenetics and epitranscriptomic machinery of the parasite have the potential of providing new weapons against malaria. View this paper
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Articles (241)

  • Article
  • Open Access
4 Citations
2,134 Views
11 Pages

A Single Nucleotide Polymorphism Translates into a Radical Amino Acid Substitution at the Ligand-Binding Site in Fasciola hepatica Carboxylesterase B

  • Estefan Miranda-Miranda,
  • Silvana Scarcella,
  • Enrique Reynaud,
  • Verónica Narváez-Padilla,
  • Gisela Neira,
  • Roberto Mera-y-Sierra,
  • Hugo Aguilar-Díaz and
  • Raquel Cossio-Bayugar

19 October 2022

Fasciola hepatica anthelmintic resistance may be associated with the catalytic activity of xenobiotic metabolizing enzymes. The gene expression of one of these enzymes, identified as carboxylesterase B (CestB), was previously described as inducible i...

  • Article
  • Open Access
27 Citations
3,776 Views
16 Pages

Effects of Different Rearing Systems on Lueyang Black-Bone Chickens: Meat Quality, Amino Acid Composition, and Breast Muscle Transcriptome

  • Shuya Zhang,
  • Jiqiao Zhang,
  • Chang Cao,
  • Yingjie Cai,
  • Yuxiao Li,
  • Yiping Song,
  • Xiuyu Bao and
  • Jianqin Zhang

19 October 2022

The quality of poultry products depends on genotype, rearing system, and environment. The aim of this study was to investigate the effects of different rearing systems on meat quality, amino acid composition, and breast muscle transcriptome from Luey...

  • Article
  • Open Access
3 Citations
2,689 Views
11 Pages

Assessment of Genetic Diversity, Runs of Homozygosity, and Signatures of Selection in Tropical Milking Criollo Cattle Using Pedigree and Genomic Data

  • Ricardo Martínez-Rocha,
  • Jorge Hidalgo,
  • Alberto Cesarani,
  • Rodolfo Ramírez-Valverde,
  • Rafael Núñez-Domínguez,
  • José Guadalupe García-Muñiz and
  • Joel Domínguez-Viveros

19 October 2022

The objective of this study was to evaluate the genetic diversity of the Tropical Milking Criollo cattle (TMC) breed in Mexico through parameters derived from pedigree and genomic information assessment. The pedigree file consisted of 3780 animals. S...

  • Article
  • Open Access
2 Citations
2,566 Views
18 Pages

19 October 2022

Clear cell renal cell carcinoma (ccRCC) is the most frequent kind of kidney malignancy. Inflammation is a physiological response of the immune system to harmful stimuli. Notably, the role inflammation plays in ccRCC is still unknown. In this study, c...

  • Article
  • Open Access
2 Citations
2,931 Views
16 Pages

A Novel Module Promotes Horizontal Gene Transfer in Azorhizobium caulinodans ORS571

  • Mingxu Li,
  • Qianqian Chen,
  • Chuanhui Wu,
  • Yiyang Li,
  • Sanle Wang,
  • Xuelian Chen,
  • Bowen Qiu,
  • Yuxin Li,
  • Dongmei Mao and
  • Hong Lin
  • + 5 authors

19 October 2022

Azorhizobium caulinodans ORS571 contains an 87.6 kb integrative and conjugative element (ICEAc) that conjugatively transfers symbiosis genes to other rhizobia. Many hypothetical redundant gene fragments (rgfs) are abundant in ICEAc, but their potenti...

  • Review
  • Open Access
13 Citations
5,247 Views
11 Pages

The PPARGC1A Is the Gene Responsible for Thrifty Metabolism Related Metabolic Diseases: A Scoping Review

  • Riandini Aisyah,
  • Ahmad Hamim Sadewa,
  • Suryono Yudha Patria and
  • Abdul Wahab

18 October 2022

The “thrifty genotype” hypothesis has thus far described the relationship between specific genes and the population’s resilience to food scarcity circumstances, but its link to the widespread prevalence of genetic diseases and metab...

  • Review
  • Open Access
10 Citations
4,800 Views
20 Pages

18 October 2022

Alport syndrome is a hereditary kidney disease caused by mutations in the three genes encoding for collagen IV: COL4A3, COL4A4, and COL4A5. Several mouse models have been created for the study of this disease with variable phenotypic outcomes. This r...

  • Article
  • Open Access
14 Citations
3,350 Views
17 Pages

The Banana MaWRKY18, MaWRKY45, MaWRKY60 and MaWRKY70 Genes Encode Functional Transcription Factors and Display Differential Expression in Response to Defense Phytohormones

  • Sergio García-Laynes,
  • Virginia Aurora Herrera-Valencia,
  • Lilia Guadalupe Tamayo-Torres,
  • Verónica Limones-Briones,
  • Felipe Alonso Barredo-Pool,
  • Fray Martin Baas-Espinola,
  • Angel Gabriel Alpuche-Solís,
  • Carlos Puch-Hau and
  • Santy Peraza-Echeverria

18 October 2022

WRKY transcription factors (TFs) play key roles in plant defense responses through phytohormone signaling pathways. However, their functions in tropical fruit crops, especially in banana, remain largely unknown. Several WRKY genes from the model plan...

  • Article
  • Open Access
12 Citations
3,534 Views
15 Pages

RNA Modification-Related Genetic Variants in Genomic Loci Associated with Bone Mineral Density and Fracture

  • Limin Han,
  • Jingyun Wu,
  • Mimi Wang,
  • Zhentao Zhang,
  • Dian Hua,
  • Shufeng Lei and
  • Xingbo Mo

18 October 2022

Genome-wide association studies (GWASs) have identified more than 500 loci for bone mineral density (BMD), but functional variants in these loci are less known. The aim of this study was to identify RNA modification-related SNPs (RNAm-SNPs) for BMD i...

  • Article
  • Open Access
1 Citations
2,916 Views
17 Pages

18 October 2022

(1) Background: analyses of gene networks can elucidate hematopoietic differentiation from single-cell gene expression data, but most algorithms generate only a single, static network. Because gene interactions change over time, it is biologically me...

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Genes - ISSN 2073-4425