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Therapeutic Advances of Stem Cell-Derived Extracellular Vesicles in Regenerative Medicine

Zhenjiang Key Laboratory of High Technology Research on Exosomes Foundation and Transformation Application, Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, Jiangsu, China
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These authors contributed equally to this work.
Cells 2020, 9(3), 707; https://doi.org/10.3390/cells9030707
Received: 16 December 2019 / Revised: 7 March 2020 / Accepted: 10 March 2020 / Published: 13 March 2020
Extracellular vesicles (EVs), which are the main paracrine components of stem cells, mimic the regenerative capacity of these cells. Stem cell-derived EVs (SC-EVs) have been used for the treatment of various forms of tissue injury in preclinical trials through maintenance of their stemness, induction of regenerative phenotypes, apoptosis inhibition, and immune regulation. The efficiency of SC-EVs may be enhanced by selecting the appropriate EV-producing cells and cell phenotypes, optimizing cell culture conditions for the production of optimal EVs, and further engineering the EVs produced to transport therapeutic and targeting molecules. View Full-Text
Keywords: stem cell; extracellular vesicle; tissue damage; regenerative medicine stem cell; extracellular vesicle; tissue damage; regenerative medicine
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MDPI and ACS Style

Yin, L.; Liu, X.; Shi, Y.; Ocansey, D.K.W.; Hu, Y.; Li, X.; Zhang, C.; Xu, W.; Qian, H. Therapeutic Advances of Stem Cell-Derived Extracellular Vesicles in Regenerative Medicine. Cells 2020, 9, 707.

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