Context-Dependent Distinct Roles of SOX9 in Combined Hepatocellular Carcinoma–Cholangiocarcinoma
Abstract
1. Introduction
2. Materials and Methods
2.1. Mouse Husbandry and Breeding
2.2. Patient Data
3. Results
3.1. Forced Expression of Myristoylated Akt and YAP1 in HC Yields cHCC-CCA, While the Chronic Elimination of Sox9 Induces Molecular Phenotype Switch to an Aggressive HCC
3.2. Transcriptomic Analysis of HCC in Akt-YAP1 Model in Sox9-LKO Reveals Significant Similarity to a Subset of Human HCCs
3.3. SOX9 Is Dispensable for Akt-YAP1-Mediated LPC-like Immature CCA Nodule Formation but Required for Their Transformation into Mature CCA
3.4. Distinct Roles SOX9 in Akt-YAP1-Driven HCC Tumor in Regulating Proliferation
3.5. Tumor-Specific Acute Sox9 Loss Represses YAP1 or NRAS-Dependent cHCC-CCA Development
3.6. Therapeutic Deletion of Sox9 Significantly Reduces Advanced Akt-YAP1 Liver Cancer
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Park, Y.; Hu, S.; Kim, M.; Oertel, M.; Singhi, A.; Monga, S.P.; Liu, S.; Ko, S. Context-Dependent Distinct Roles of SOX9 in Combined Hepatocellular Carcinoma–Cholangiocarcinoma. Cells 2024, 13, 1451. https://doi.org/10.3390/cells13171451
Park Y, Hu S, Kim M, Oertel M, Singhi A, Monga SP, Liu S, Ko S. Context-Dependent Distinct Roles of SOX9 in Combined Hepatocellular Carcinoma–Cholangiocarcinoma. Cells. 2024; 13(17):1451. https://doi.org/10.3390/cells13171451
Chicago/Turabian StylePark, Yoojeong, Shikai Hu, Minwook Kim, Michael Oertel, Aatur Singhi, Satdarshan P. Monga, Silvia Liu, and Sungjin Ko. 2024. "Context-Dependent Distinct Roles of SOX9 in Combined Hepatocellular Carcinoma–Cholangiocarcinoma" Cells 13, no. 17: 1451. https://doi.org/10.3390/cells13171451
APA StylePark, Y., Hu, S., Kim, M., Oertel, M., Singhi, A., Monga, S. P., Liu, S., & Ko, S. (2024). Context-Dependent Distinct Roles of SOX9 in Combined Hepatocellular Carcinoma–Cholangiocarcinoma. Cells, 13(17), 1451. https://doi.org/10.3390/cells13171451