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Review

The Chemical Inhibitors of Endocytosis: From Mechanisms to Potential Clinical Applications

1
Department of Synthesis and Technology of Drugs, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland
2
Department of Biotechnology, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland
3
CNRS, UMR 9018, Institut Gustave Roussy, Université Paris-Saclay, 94800 Villejuif, France
4
Department of Regulation of Cell Proliferation and Apoptosis, Institute of Cell Biology of National Academy of Sciences of Ukraine, Drahomanov 14/16, 79005 Lviv, Ukraine
5
Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010 Lviv, Ukraine
*
Authors to whom correspondence should be addressed.
Cells 2023, 12(18), 2312; https://doi.org/10.3390/cells12182312
Submission received: 16 August 2023 / Accepted: 7 September 2023 / Published: 19 September 2023
(This article belongs to the Section Cellular Pathology)

Abstract

Endocytosis is one of the major ways cells communicate with their environment. This process is frequently hijacked by pathogens. Endocytosis also participates in the oncogenic transformation. Here, we review the approaches to inhibit endocytosis, discuss chemical inhibitors of this process, and discuss potential clinical applications of the endocytosis inhibitors.
Keywords: clathrin-mediated endocytosis; clathrin-independent endocytosis; cell-penetrating peptides; inhibitors of endocytosis clathrin-mediated endocytosis; clathrin-independent endocytosis; cell-penetrating peptides; inhibitors of endocytosis
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MDPI and ACS Style

Szewczyk-Roszczenko, O.K.; Roszczenko, P.; Shmakova, A.; Finiuk, N.; Holota, S.; Lesyk, R.; Bielawska, A.; Vassetzky, Y.; Bielawski, K. The Chemical Inhibitors of Endocytosis: From Mechanisms to Potential Clinical Applications. Cells 2023, 12, 2312. https://doi.org/10.3390/cells12182312

AMA Style

Szewczyk-Roszczenko OK, Roszczenko P, Shmakova A, Finiuk N, Holota S, Lesyk R, Bielawska A, Vassetzky Y, Bielawski K. The Chemical Inhibitors of Endocytosis: From Mechanisms to Potential Clinical Applications. Cells. 2023; 12(18):2312. https://doi.org/10.3390/cells12182312

Chicago/Turabian Style

Szewczyk-Roszczenko, Olga Klaudia, Piotr Roszczenko, Anna Shmakova, Nataliya Finiuk, Serhii Holota, Roman Lesyk, Anna Bielawska, Yegor Vassetzky, and Krzysztof Bielawski. 2023. "The Chemical Inhibitors of Endocytosis: From Mechanisms to Potential Clinical Applications" Cells 12, no. 18: 2312. https://doi.org/10.3390/cells12182312

APA Style

Szewczyk-Roszczenko, O. K., Roszczenko, P., Shmakova, A., Finiuk, N., Holota, S., Lesyk, R., Bielawska, A., Vassetzky, Y., & Bielawski, K. (2023). The Chemical Inhibitors of Endocytosis: From Mechanisms to Potential Clinical Applications. Cells, 12(18), 2312. https://doi.org/10.3390/cells12182312

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