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Review

The Multiple Roles of Periostin in Non-Neoplastic Disease

by
Lina Yang
1,2,†,
Tongtong Guo
1,†,
Yuanyuan Chen
1,† and
Ka Bian
2,*
1
College of Life Science, Northwest University, Xi’an 710069, China
2
Department of Otorhinolaryngology, Tangdu Hospital, Fourth Military Medical University, Xi’an 710032, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Cells 2023, 12(1), 50; https://doi.org/10.3390/cells12010050
Submission received: 12 November 2022 / Revised: 5 December 2022 / Accepted: 20 December 2022 / Published: 22 December 2022
(This article belongs to the Section Cell Motility and Adhesion)
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Abstract

Periostin, identified as a matricellular protein and an ECM protein, plays a central role in non-neoplastic diseases. Periostin and its variants have been considered to be normally involved in the progression of most non-neoplastic diseases, including brain injury, ocular diseases, chronic rhinosinusitis, allergic rhinitis, dental diseases, atopic dermatitis, scleroderma, eosinophilic esophagitis, asthma, cardiovascular diseases, lung diseases, liver diseases, chronic kidney diseases, inflammatory bowel disease, and osteoarthrosis. Periostin interacts with protein receptors and transduces signals primarily through the PI3K/Akt and FAK two channels as well as other pathways to elicit tissue remodeling, fibrosis, inflammation, wound healing, repair, angiogenesis, tissue regeneration, bone formation, barrier, and vascular calcification. This review comprehensively integrates the multiple roles of periostin and its variants in non-neoplastic diseases, proposes the utility of periostin as a biological biomarker, and provides potential drug-developing strategies for targeting periostin.
Keywords: periostin; variants; non-neoplastic diseases; roles; biomarker; drug periostin; variants; non-neoplastic diseases; roles; biomarker; drug

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MDPI and ACS Style

Yang, L.; Guo, T.; Chen, Y.; Bian, K. The Multiple Roles of Periostin in Non-Neoplastic Disease. Cells 2023, 12, 50. https://doi.org/10.3390/cells12010050

AMA Style

Yang L, Guo T, Chen Y, Bian K. The Multiple Roles of Periostin in Non-Neoplastic Disease. Cells. 2023; 12(1):50. https://doi.org/10.3390/cells12010050

Chicago/Turabian Style

Yang, Lina, Tongtong Guo, Yuanyuan Chen, and Ka Bian. 2023. "The Multiple Roles of Periostin in Non-Neoplastic Disease" Cells 12, no. 1: 50. https://doi.org/10.3390/cells12010050

APA Style

Yang, L., Guo, T., Chen, Y., & Bian, K. (2023). The Multiple Roles of Periostin in Non-Neoplastic Disease. Cells, 12(1), 50. https://doi.org/10.3390/cells12010050

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