Next Article in Journal
Characterization and Effect of Ag(0) vs. Ag(I) Species and Their Localized Plasmon Resonance on Photochemically Inactive TiO2
Next Article in Special Issue
Synthesis of Ribavirin, Tecadenoson, and Cladribine by Enzymatic Transglycosylation
Previous Article in Journal
Tetracopper(II) Cores Driven by an Unexplored Trifunctional Aminoalcohol Sulfonic Acid for Mild Catalytic C–H Functionalization of Alkanes
Previous Article in Special Issue
A Photo-Enzymatic Cascade to Transform Racemic Alcohols into Enantiomerically Pure Amines
Article Menu

Export Article

Open AccessFeature PaperReview
Catalysts 2019, 9(4), 322;

Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals

Departamento de Química Bio-orgánica, IQOG-CSIC. c/Juan de la Cierva 3, E-28006 Madrid, Spain
Facultad de Tecnología, Carrera de Ingeniería Química, Universidad Mayor Real y Pontífice de San Francisco Xavier de Chuquisaca, Regimiento Campos 180, Casilla 60-B, Sucre, Bolivia
Authors to whom correspondence should be addressed.
Received: 27 February 2019 / Revised: 18 March 2019 / Accepted: 19 March 2019 / Published: 1 April 2019
PDF [5085 KB, uploaded 1 April 2019]
  |     |  


Chondroitin sulfates are linear anionic sulfated polysaccharides found in biological tissues, mainly within the extracellular matrix, which are degraded and altered by specific lyases depending on specific time points. These polysaccharides have recently acquired relevance in the pharmaceutical industry due to their interesting therapeutic applications. As a consequence, chondroitin sulfate (CS) lyases have been widely investigated as tools for the development of new pharmaceuticals based on these polysaccharides. This review focuses on the major breakthrough represented by chondroitin sulfate-degrading enzymes and their structures and mechanisms of function in addition to their major applications. View Full-Text
Keywords: lyases; chondroitin sulfates; glycosaminoglycan; polysaccharides lyases; chondroitin sulfates; glycosaminoglycan; polysaccharides

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Benito-Arenas, R.; Zárate, S.G.; Revuelta, J.; Bastida, A. Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals. Catalysts 2019, 9, 322.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Catalysts EISSN 2073-4344 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top