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Catalysts 2019, 9(4), 322; https://doi.org/10.3390/catal9040322

Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals

1
Departamento de Química Bio-orgánica, IQOG-CSIC. c/Juan de la Cierva 3, E-28006 Madrid, Spain
2
Facultad de Tecnología, Carrera de Ingeniería Química, Universidad Mayor Real y Pontífice de San Francisco Xavier de Chuquisaca, Regimiento Campos 180, Casilla 60-B, Sucre, Bolivia
*
Authors to whom correspondence should be addressed.
Received: 27 February 2019 / Revised: 18 March 2019 / Accepted: 19 March 2019 / Published: 1 April 2019
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Abstract

Chondroitin sulfates are linear anionic sulfated polysaccharides found in biological tissues, mainly within the extracellular matrix, which are degraded and altered by specific lyases depending on specific time points. These polysaccharides have recently acquired relevance in the pharmaceutical industry due to their interesting therapeutic applications. As a consequence, chondroitin sulfate (CS) lyases have been widely investigated as tools for the development of new pharmaceuticals based on these polysaccharides. This review focuses on the major breakthrough represented by chondroitin sulfate-degrading enzymes and their structures and mechanisms of function in addition to their major applications. View Full-Text
Keywords: lyases; chondroitin sulfates; glycosaminoglycan; polysaccharides lyases; chondroitin sulfates; glycosaminoglycan; polysaccharides
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Benito-Arenas, R.; Zárate, S.G.; Revuelta, J.; Bastida, A. Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals. Catalysts 2019, 9, 322.

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