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  • Review
  • Open Access
1 Citations
2,568 Views
38 Pages

Antibacterial Polysaccharides in Dental Implantology

  • Lubica Hallmann and
  • Mark Daniel Gerngroß

4 August 2025

Background: The aim of this review is to summarize and evaluate the properties of antibacterial polysaccharides for application in dental implantology to identify knowledge gaps and provide new research ideas. Methods: The electronic databases PubMed...

  • Article
  • Open Access
4 Citations
4,661 Views
15 Pages

Labeling of Polysaccharides with Biotin and Fluorescent Dyes

  • Alexander Tuzikov,
  • Nadezhda Shilova,
  • Tatiana Ovchinnikova,
  • Alexey Nokel,
  • Olga Patova,
  • Yuriy Knirel,
  • Tatiana Chernova,
  • Tatiana Gorshkova and
  • Nicolai Bovin

Examples of labeling polysaccharides at hydroxyl groups are described in this paper, which are especially in demand for molecules with a blocked reducing end. The protocols presented are suitable for the microscale synthesis of labeled polysaccharide...

  • Review
  • Open Access
138 Citations
13,003 Views
30 Pages

Polysaccharides in Ocular Drug Delivery

  • Natallia Dubashynskaya,
  • Daria Poshina,
  • Sergei Raik,
  • Arto Urtti and
  • Yury A. Skorik

Polysaccharides, such as cellulose, hyaluronic acid, alginic acid, and chitosan, as well as polysaccharide derivatives, have been successfully used to augment drug delivery in the treatment of ocular pathologies. The properties of polysaccharides can...

  • Review
  • Open Access
218 Citations
16,794 Views
31 Pages

Bioactive Polysaccharides from Seaweeds

  • Faiez Hentati,
  • Latifa Tounsi,
  • Djomdi Djomdi,
  • Guillaume Pierre,
  • Cédric Delattre,
  • Alina Violeta Ursu,
  • Imen Fendri,
  • Slim Abdelkafi and
  • Philippe Michaud

Bioactive compounds with diverse chemical structures play a significant role in disease prevention and maintenance of physiological functions. Due to the increase in industrial demand for new biosourced molecules, several types of biomasses are being...

  • Review
  • Open Access
359 Citations
20,007 Views
22 Pages

12 December 2012

Recently, the studies on the antiviral activities of marine natural products, especially marine polysaccharides, are attracting more and more attention all over the world. Marine-derived polysaccharides and their lower molecular weight oligosaccharid...

  • Article
  • Open Access
2 Citations
2,040 Views
24 Pages

Microbiomic and Metabolomic Insights into the Mechanisms of Alfalfa Polysaccharides and Seaweed Polysaccharides in Alleviating Diarrhea in Pre-Weaning Holstein Calves

  • Jianan Zhao,
  • Haoliang Tian,
  • Xiaohui Kong,
  • Danqi Dang,
  • Kaizhen Liu,
  • Chuanyou Su,
  • Hongxia Lian,
  • Tengyun Gao,
  • Tong Fu and
  • Wei Zhang
  • + 2 authors

8 February 2025

Neonatal calves’ diarrhea, which can be severe enough to cause death, has a significant impact on the global cattle industry. In this study, alfalfa polysaccharides and seaweed polysaccharides were found to significantly improve the diarrhea co...

  • Review
  • Open Access
19 Citations
3,821 Views
16 Pages

8 November 2022

The purpose of this study is to explore the effects of pine pollen polysaccharides and sulfated polysaccharides on mice with ulcerative colitis and whether they could protect mice from inflammation by regulating the tight junctions of colonic epithel...

  • Article
  • Open Access
25 Citations
4,386 Views
19 Pages

13 March 2023

Polysaccharides are important biological macromolecules in all organisms, and have recently been studied as therapeutic agents for ulcerative colitis (UC). However, the effects of Pinus yunnanensis pollen polysaccharides on ulcerative colitis remains...

  • Review
  • Open Access
34 Citations
6,077 Views
19 Pages

An Overview of Antitumour Activity of Polysaccharides

  • Hongzhen Jin,
  • Maohua Li,
  • Feng Tian,
  • Fan Yu and
  • Wei Zhao

21 November 2022

Cancer incidence and mortality are rapidly increasing worldwide; therefore, effective therapies are required in the current scenario of increasing cancer cases. Polysaccharides are a family of natural polymers that hold unique physicochemical and bio...

  • Review
  • Open Access
121 Citations
15,631 Views
47 Pages

Polysaccharides for the Delivery of Antitumor Drugs

  • Bianca Posocco,
  • Eva Dreussi,
  • Jacopo De Santa,
  • Giuseppe Toffoli,
  • Michela Abrami,
  • Francesco Musiani,
  • Mario Grassi,
  • Rossella Farra,
  • Federica Tonon and
  • Barbara Dapas
  • + 1 author

13 May 2015

Among the several delivery materials available so far, polysaccharides represent very attractive molecules as they can undergo a wide range of chemical modifications, are biocompatible, biodegradable, and have low immunogenic properties. Thus, polysa...

  • Review
  • Open Access
86 Citations
19,035 Views
45 Pages

Polysaccharides: The “Click” Chemistry Impact

  • Pierre-Henri Elchinger,
  • Pierre-Antoine Faugeras,
  • Benjamin Boëns,
  • François Brouillette,
  • Daniel Montplaisir,
  • Rachida Zerrouki and
  • Romain Lucas

27 September 2011

Polysaccharides are complex but essential compounds utilized in many areas such as biomaterials, drug delivery, cosmetics, food chemistry or renewable energy. Modifications and functionalizations of such polymers are often necessary to achieve molecu...

  • Article
  • Open Access
19 Citations
3,389 Views
20 Pages

Preparation, Characterization, and Bioactivities of Polysaccharide–Nano-Selenium and Selenized Polysaccharides from Acanthopanax senticosus

  • Xiaoli Li,
  • Ying Li,
  • Xueyan Wang,
  • Rui Zhang,
  • Jiaojiao Xue,
  • Yi Ding,
  • Xiuling Chu and
  • Jianqing Su

22 March 2024

Acanthopanax senticosus polysaccharide–nano-selenium (ASPS-SENPS) and A. selenopanax selenized polysaccharides (Se-ASPS) were synthesized, and their characterization and biological properties were compared. The acid extraction method was used t...

  • Review
  • Open Access
122 Citations
9,333 Views
17 Pages

Structural Modification and Biological Activity of Polysaccharides

  • Ting Zhao,
  • Min Yang,
  • Lina Ma,
  • Xinglong Liu,
  • Qiteng Ding,
  • Guodong Chai,
  • Yang Lu,
  • Hewei Wei,
  • Shuai Zhang and
  • Chuanbo Ding

14 July 2023

Natural polysaccharides are macromolecular substances with a wide range of biological activities. The structural modification of polysaccharides by chemical means can enhance their biological activity. This paper reviews the latest research reports o...

  • Review
  • Open Access
63 Citations
9,314 Views
31 Pages

Antithrombotics from the Sea: Polysaccharides and Beyond

  • Francisca Carvalhal,
  • Ricardo R. Cristelo,
  • Diana I. S. P. Resende,
  • Madalena M. M. Pinto,
  • Emília Sousa and
  • Marta Correia-da-Silva

16 March 2019

Marine organisms exhibit some advantages as a renewable source of potential drugs, far beyond chemotherapics. Particularly, the number of marine natural products with antithrombotic activity has increased in the last few years, and reports show a wid...

  • Review
  • Open Access
147 Citations
13,266 Views
43 Pages

Polysaccharides are naturally occurring complex molecules with exceptional physicochemical properties and bioactivities. They originate from plant, animal, and microbial-based resources and processes and can be chemically modified. The biocompatibili...

  • Article
  • Open Access
2 Citations
5,190 Views
10 Pages

Extended Polysaccharide Analysis within the Liposomal Encapsulation of Polysaccharides System

  • Roozbeh Nayerhoda,
  • Dongwon Park,
  • Charles Jones,
  • Elsa N. Bou Ghanem and
  • Blaine A. Pfeifer

26 July 2020

The Liposomal Encapsulation of Polysaccharides (LEPS) dual antigen vaccine carrier system was assessed across two distinct polysaccharides for encapsulation efficiency, subsequent liposomal surface adornment with protein, adjuvant addition, and size...

  • Review
  • Open Access
19 Citations
4,942 Views
16 Pages

7 March 2021

Bacteria produce a variety of multifunctional polysaccharides, including structural, intracellular, and extracellular polysaccharides. They are attractive for the industrial sector due to their natural origin, sustainability, biodegradability, low to...

  • Review
  • Open Access
20 Citations
13,818 Views
21 Pages

Cordyceps Polysaccharides: A Review of Their Immunomodulatory Effects

  • Liping Chen,
  • Xiao Liu,
  • Kaiyue Zheng,
  • Yang Wang,
  • Minglong Li,
  • Yuyu Zhang,
  • Yuan Cui,
  • Sichun Deng,
  • Shiqi Liu and
  • Yuxin He
  • + 2 authors

29 October 2024

Cordyceps primarily consists of ascomycetes, a parasitic fungus that infects insects and arthropods. Recently, Cordyceps has been shown to manifest a diverse range of pharmacological activities, rendering it applicable for the treatment and mitigatio...

  • Review
  • Open Access
193 Citations
17,499 Views
23 Pages

Sources, Extraction and Biomedical Properties of Polysaccharides

  • Samee Ullah,
  • Anees Ahmed Khalil,
  • Faryal Shaukat and
  • Yuanda Song

1 August 2019

In the recent era, bioactive compounds from plants have received great attention because of their vital health-related activities, such as antimicrobial activity, antioxidant activity, anticoagulant activity, anti-diabetic activity, UV protection, an...

  • Review
  • Open Access
80 Citations
13,715 Views
29 Pages

Immune Recognition of Fungal Polysaccharides

  • Brendan D. Snarr,
  • Salman T. Qureshi and
  • Donald C. Sheppard

28 August 2017

The incidence of fungal infections has dramatically increased in recent years, in large part due to increased use of immunosuppressive medications, as well as aggressive medical and surgical interventions that compromise natural skin and mucosal barr...

  • Review
  • Open Access
95 Citations
11,202 Views
21 Pages

Recent Advancements in Microbial Polysaccharides: Synthesis and Applications

  • Yehia A.-G. Mahmoud,
  • Mehrez E. El-Naggar,
  • Ahmed Abdel-Megeed and
  • Mohamed El-Newehy

26 November 2021

Polysaccharide materials are widely applied in different applications including food, food packaging, drug delivery, tissue engineering, wound dressing, wastewater treatment, and bioremediation sectors. They were used in these domains due to their ef...

  • Review
  • Open Access
97 Citations
14,508 Views
59 Pages

29 April 2022

Hydrogels are three-dimensional crosslinked hydrophilic polymer networks with great potential in drug delivery, tissue engineering, wound dressing, agrochemicals application, food packaging, and cosmetics. However, conventional synthetic polymer hydr...

  • Review
  • Open Access
5 Citations
1,788 Views
28 Pages

Modified Polysaccharides: Potential Biomaterials for Bioprinting

  • Tao Jiang,
  • Yun Yang,
  • Zening Lin,
  • Yang Hong and
  • Zirong Luo

9 September 2025

Polysaccharides have emerged as promising biomaterials for 3D bioprinting due to their inherent biocompatibility, biodegradability, and structural diversity. However, their limited mechanical strength, insufficient bioactivity, and suboptimal printab...

  • Review
  • Open Access
27 Citations
6,156 Views
26 Pages

Research Progress on the Mechanisms of Polysaccharides against Gastric Cancer

  • Liping Chen,
  • Chunrong He,
  • Min Zhou,
  • Jiaying Long and
  • Ling Li

8 September 2022

Gastric cancer is a common type of cancer that poses a serious threat to human health. Polysaccharides are important functional phytochemicals, and research shows that polysaccharides have good anti-gastric cancer effects. We collated all relevant li...

  • Article
  • Open Access
56 Citations
9,509 Views
13 Pages

Comparison of Polysaccharides from Two Species of Ganoderma

  • Jing Xie,
  • Jing Zhao,
  • De-Jun Hu,
  • Jin-Ao Duan,
  • Yu-Ping Tang and
  • Shao-Ping Li

13 January 2012

Ganoderma lucidum and Ganoderma sinense, known as Lingzhi in Chinese, are commonly used Chinese medicines with excellent beneficial health effects. Triterpenes and polysaccharides are usually considered as their main active components. However, the c...

  • Article
  • Open Access
47 Citations
9,760 Views
9 Pages

13 January 2012

Okara is a byproduct generated during tofu or soymilk production processes. Crude polysaccharide (yield 56.8%) was isolated by removing fat, protein and low molecular weight carbohydrates from initial okara. Crude okara polysaccharide was further div...

  • Article
  • Open Access
30 Citations
5,180 Views
15 Pages

Renewable Polysaccharides as Supports for Palladium Phosphine Catalysts

  • Oshrat Levy-Ontman,
  • Shira Biton,
  • Boris Shlomov and
  • Adi Wolfson

12 June 2018

The investigation of the use of polysaccharides derived from natural sources to support metal catalysis has been the focus of several studies. Even though these molecules seem to be attractive materials, their full potential for use in support of het...

  • Review
  • Open Access
43 Citations
7,223 Views
13 Pages

The Role and Mechanism of Polysaccharides in Anti-Aging

  • Xinlu Guo,
  • Junjie Luo,
  • Jingyi Qi,
  • Xiya Zhao,
  • Peng An,
  • Yongting Luo and
  • Guisheng Wang

15 December 2022

The elderly proportion of the population is gradually increasing, which poses a great burden to society, the economy, and the medical field. Aging is a physiological process involving multiple organs and numerous reactions, and therefore it is not ea...

  • Feature Paper
  • Review
  • Open Access
275 Citations
20,320 Views
27 Pages

Marine Origin Polysaccharides in Drug Delivery Systems

  • Matias J. Cardoso,
  • Rui R. Costa and
  • João F. Mano

5 February 2016

Oceans are a vast source of natural substances. In them, we find various compounds with wide biotechnological and biomedical applicabilities. The exploitation of the sea as a renewable source of biocompounds can have a positive impact on the developm...

  • Article
  • Open Access
41 Citations
14,690 Views
9 Pages

Preparation of Fast Dissolving Films for Oral Dosage from Natural Polysaccharides

  • Yoshifumi Murata,
  • Takashi Isobe,
  • Kyoko Kofuji,
  • Norihisa Nishida and
  • Ryosei Kamaguchi

9 August 2010

Fast-dissolving films (FDFs) were prepared from natural polysaccharides, such as pullulan, without heating, controlling the pH, or adding other materials. The release profiles of model drugs from the films were investigated. In the absence of a drug,...

  • Article
  • Open Access
16 Citations
3,194 Views
26 Pages

Polysaccharides from Brasenia schreberi with Great Antioxidant Ability and the Potential Application in Yogurt

  • Yujie Wang,
  • Yue Zou,
  • Qiong Fang,
  • Ruizhang Feng,
  • Jihong Zhang,
  • Wanhai Zhou and
  • Qin Wei

26 December 2023

Brasenia schreberi is a widely consumed aquatic plant, yet the knowledge regarding its bioactive components, particularly polysaccharides, remains limited. Therefore, this study aimed to optimize the extraction process of polysaccharides from B. schr...

  • Review
  • Open Access
1 Citations
1,414 Views
28 Pages

Marine Macroalgal Polysaccharides as Precision Tools for Health and Nutrition

  • José A. M. Prates,
  • Mohamed Ezzaitouni and
  • José L. Guil-Guerrero

10 October 2025

Macroalgal polysaccharides represent a diverse group of structurally complex biopolymers with significant potential in biomedicine and functional food applications. This review provides a comprehensive examination of their structural features, biolog...

  • Article
  • Open Access
8 Citations
3,017 Views
10 Pages

Polysaccharides as Stabilizers for Polymeric Microcarriers Fabrication

  • Tatiana S. Demina,
  • Liubov A. Kilyashova,
  • Tatiana N. Popyrina,
  • Eugenia A. Svidchenko,
  • Sankarprasad Bhuniya,
  • Tatiana A. Akopova and
  • Christian Grandfils

9 September 2021

Biodegradable polymeric microparticles are widely used in drug delivery systems with prolonged-release profiles and/or cell microcarriers. Their fabrication via the oil/water emulsion solvent evaporation technique has normally required emulsifiers in...

  • Review
  • Open Access
7 Citations
4,348 Views
46 Pages

Polysaccharides: The Sustainable Foreground in Energy Storage Systems

  • Sharin Maria Thomas,
  • Pedro Gómez-Romero and
  • Rosa M. González-Gil

Polysaccharides offer a perfect option as raw materials for the development of a new generation of sustainable batteries and supercapacitors. This is due to their abundance and inherent structural characteristics. Polysaccharides can be chemically fu...

  • Review
  • Open Access
102 Citations
12,682 Views
41 Pages

Polysaccharides—Naturally Occurring Immune Modulators

  • Emma J. Murphy,
  • Gustavo Waltzer Fehrenbach,
  • Ismin Zainol Abidin,
  • Ciara Buckley,
  • Therese Montgomery,
  • Robert Pogue,
  • Patrick Murray,
  • Ian Major and
  • Emanuele Rezoagli

19 May 2023

The prevention of disease and infection requires immune systems that operate effectively. This is accomplished by the elimination of infections and abnormal cells. Immune or biological therapy treats disease by either stimulating or inhibiting the im...

  • Review
  • Open Access
174 Citations
13,526 Views
22 Pages

Beneficial Effect of Intestinal Fermentation of Natural Polysaccharides

  • Tiehua Zhang,
  • Yang Yang,
  • Yuan Liang,
  • Xu Jiao and
  • Changhui Zhao

9 August 2018

With the rapid development of modern society, many chronic diseases are increasing including diabetes, obesity, cardiovascular diseases, etc., which further cause an increased death rate worldwide. A high caloric diet with reduced natural polysacchar...

  • Article
  • Open Access
1 Citations
1,126 Views
16 Pages

Preparation, Characterization and Bioactivities of Strawberry Polysaccharides

  • Libo Wang,
  • Yumeng Zhao,
  • Junwen Liu,
  • Ling Zhu,
  • Yanhui Wei,
  • Kun Cheng and
  • Yaqin Xu

24 March 2025

The aim of this research was to characterize the structure, physicochemical properties and anti-complement activities of two strawberry fruit polysaccharides (DSFP-500 and DSFP-700) obtained by ultrasonic degradation. The molecular weight (Mw) of DSF...

  • Review
  • Open Access
42 Citations
7,839 Views
15 Pages

Prebiotic Effects of Seaweed Polysaccharides in Pigs

  • Carlo Corino,
  • Alessia Di Giancamillo,
  • Silvia Clotilde Modina and
  • Raffaella Rossi

27 May 2021

To ensure environmental sustainability, according to the European Green Deal and to boost the One Health concept, it is essential to improve animals’ health and adopt sustainable and natural feed ingredients. Over the past decade, prebiotics have bee...

  • Article
  • Open Access
3 Citations
2,141 Views
18 Pages

Comparison of Polygonatum sibiricum Polysaccharides from Different Extraction Methods

  • Yan Chen,
  • Hanchen Du,
  • Wenjie Qu,
  • Chaoqun Sun,
  • Qu Chen,
  • Yuping Du,
  • Zhuoyuan Zhang,
  • Yiran Guo,
  • Chonglin Wang and
  • Jiyong Yin
  • + 1 author

23 June 2025

Although our previous research has indicated that the ultrasound-assisted extraction–deep eutectic solvent method possessed the highest extraction yield for Polygonatum sibiricum Polysaccharide, it is uncertain whether the Polygonatum sibiricum...

  • Review
  • Open Access
161 Citations
14,299 Views
28 Pages

13 July 2019

Diabetes mellitus is a multifactorial, heterogeneous metabolic disorder, causing various health complications and economic issues, which apparently impacts the human’s life. Currently, commercial diabetic drugs are clinically managed for diabet...

  • Article
  • Open Access
71 Citations
10,852 Views
12 Pages

23 October 2014

The water-extractable (QWP) and the alkali-extractable (QAP) polysaccharides from quinoa (named QWP and QAP, respectively) and their four polysaccharide sub-fractions (QWP-1, QWP-2, QAP-1 and QAP-2), were isolated and purified by anion-exchange and...

  • Review
  • Open Access
33 Citations
7,477 Views
27 Pages

Polysaccharides as Protective Agents against Heavy Metal Toxicity

  • Lukman Iddrisu,
  • Felix Danso,
  • Kit-Leong Cheong,
  • Zhijia Fang and
  • Saiyi Zhong

11 March 2024

Polysaccharides are functional foods or drugs that can be used to alleviate heavy metal poisoning by cadmium, lead, mercury, and arsenic. Industries generate substantial quantities of toxic heavy metal wastes, such as wastewater discharges, paints, e...

  • Article
  • Open Access
9 Citations
2,580 Views
13 Pages

27 August 2023

The microbial fermentation of plants is a promising approach for enhancing the yield of polysaccharides with increased activity. In this study, ten microbial strains, Lactiplantibacillus plantarum CCFM8661, Limosilactobacillus reuteri CCFM8631, Lacto...

  • Review
  • Open Access
32 Citations
5,313 Views
15 Pages

14 April 2021

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-initiated outbreak of COVID-19 has spread rapidly around the world, posing a huge threat to public health. Natural oligo- and polysaccharides with low toxicity, good sustainability, hig...

  • Review
  • Open Access
88 Citations
11,075 Views
13 Pages

Immunomodulatory Properties of Polysaccharides from Lentinula edodes

  • Aleksander Roszczyk,
  • Jadwiga Turło,
  • Radosław Zagożdżon and
  • Beata Kaleta

11 August 2022

Lentinula edodes (Berk.) Pegler, also known as shiitake mushroom, is a popular edible macrofungus and a source of numerous bioactive substances with multiple beneficial health effects. L. edodes-derived polysaccharides are the most valuable compounds...

  • Review
  • Open Access
5 Citations
3,791 Views
16 Pages

3 February 2025

Cardiovascular risk is a clinical factor that represents the probability of developing cardiovascular diseases (CVDs). This risk is shaped by non-modifiable and modifiable factors, including dietary patterns, which are the main lifestyle factor influ...

  • Review
  • Open Access
48 Citations
6,337 Views
17 Pages

An Insight into Antihyperlipidemic Effects of Polysaccharides from Natural Resources

  • Yong-Shuai Jing,
  • Yun-Feng Ma,
  • Fei-Bing Pan,
  • Ming-Song Li,
  • Yu-Guang Zheng,
  • Lan-Fang Wu and
  • Dan-Shen Zhang

15 March 2022

Hyperlipidemia is a chronic metabolic disease caused by the abnormal metabolism of lipoproteins in the human body. Its main hazard is to accelerate systemic atherosclerosis, which causes cerebrovascular diseases such as coronary heart disease and thr...

  • Article
  • Open Access
12 Citations
2,638 Views
13 Pages

Analysis of Structure and Antioxidant Activity of Polysaccharides from Aralia continentalis

  • Yan-bo Hu,
  • Hui-li Hong,
  • Li-yang Liu,
  • Jia-ning Zhou,
  • Yue Wang,
  • Yi-ming Li,
  • Li-yuan Zhai,
  • Zeng-hui Shi,
  • Jun Zhao and
  • Duo Liu

13 December 2022

We extracted, purified, and characterized three neutral and three acidic polysaccharides from the roots, stems, and leaves of Aralia continentalis Kitigawa. The results of the analysis of monosaccharide composition indicated that the polysaccharides...

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