Monoclonal Gammopathy of Undetermined Significance (MGUS)—Not So Asymptomatic after All
1
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA
2
Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(6), 1554; https://doi.org/10.3390/cancers12061554
Received: 18 April 2020
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Revised: 7 June 2020
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Accepted: 10 June 2020
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Published: 12 June 2020
(This article belongs to the Special Issue The Asymptomatic Version of Myeloma: MGUS and Smoldering Myeloma)
Monoclonal Gammopathy of Undetermined Significance (MGUS) is considered to be a benign precursor condition that may progress to a lymphoproliferative disease or multiple myeloma. Most patients do not progress to an overt condition, but nevertheless, MGUS is associated with a shortened life expectancy and, in a minority of cases, a number of co-morbid conditions that include an increased fracture risk, renal impairment, peripheral neuropathy, secondary immunodeficiency, and cardiovascular disease. This review aims to consolidate current evidence for the significance of these co-morbidities before considering how best to approach these symptoms and signs, which are often encountered in primary care or within a number of specialties in secondary care.
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Keywords:
MGUS; multiple myeloma; paraprotein; neuropathy; fracture; MGRS; osteoporosis
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MDPI and ACS Style
Lomas, O.C.; Mouhieddine, T.H.; Tahri, S.; Ghobrial, I.M. Monoclonal Gammopathy of Undetermined Significance (MGUS)—Not So Asymptomatic after All. Cancers 2020, 12, 1554. https://doi.org/10.3390/cancers12061554
AMA Style
Lomas OC, Mouhieddine TH, Tahri S, Ghobrial IM. Monoclonal Gammopathy of Undetermined Significance (MGUS)—Not So Asymptomatic after All. Cancers. 2020; 12(6):1554. https://doi.org/10.3390/cancers12061554
Chicago/Turabian StyleLomas, Oliver C., Tarek H. Mouhieddine, Sabrin Tahri, and Irene M. Ghobrial. 2020. "Monoclonal Gammopathy of Undetermined Significance (MGUS)—Not So Asymptomatic after All" Cancers 12, no. 6: 1554. https://doi.org/10.3390/cancers12061554
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